Abstract
Since 1970, the basic concept of the Berlin-Frankfurt-Münster (BFM) study group trials for childhood acute lymphoblastic leukemia (ALL) has been intensified and prolonged induction and consolidation chemotherapy [9, 10]. In 1976, a trial was started with the aim of improving the prognosis of patients with high risk for relapse features, mainly characterized by an elevated WBC ≥25000/mm3. After successful remission induction these patients received an intensive reinduction protocol of 6 weeks duration early in remission, i.e., during the first 6 months after diagnosis, which increased the event-free survival (EFS) by about 30% compared with the historical control group of study ALL BFM 70 [3].
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Henze, G., Fengler, R., Reiter, A., Ritter, J., Riehm, H. (1990). Impact of Early Intensive Reinduction Therapy on Event-Free Survival in Children with Low-Risk Acute Lymphoblastic Leukemia. In: Büchner, T., Schellong, G., Hiddemann, W., Ritter, J. (eds) Acute Leukemias II. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74643-7_87
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DOI: https://doi.org/10.1007/978-3-642-74643-7_87
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