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Acute Leukemias II

Prognostic Factors and Treatment Strategies

  • Conference proceedings
  • © 1990

Overview

Editors:
  1. T. Büchner

    1. Departments of Internal Medicine and Pediatrics, University of Münster, Münster, Federal Republic of Germany

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  2. G. Schellong

    1. Departments of Internal Medicine and Pediatrics, University of Münster, Münster, Federal Republic of Germany

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  3. W. Hiddemann

    1. Departments of Internal Medicine and Pediatrics, University of Münster, Münster, Federal Republic of Germany

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  4. J. Ritter

    1. Departments of Internal Medicine and Pediatrics, University of Münster, Münster, Federal Republic of Germany

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Part of the book series: Haematology and Blood Transfusion Hämatologie und Bluttransfusion (HAEMATOLOGY, volume 33)

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Table of contents (138 papers)

  1. Front Matter

    Pages I-XXXI
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  2. Leukemia Cell Biology and Basic Science

    1. Front Matter

      Pages 1-1
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    2. Myelodysplastic Syndromes:Preleukemic or Early Leukemic Conditions?

      • P. Dörmer
      Pages 3-7

    3. Mechanisms of Autocrine and Paracrine Growth Control in Acute Myelogenous Leukemia

      • W. Oster, R. Mertelsmann, F. Herrmann
      Pages 8-16

    4. Clonal Analysis of Human Leukemias by Molecular Genetic Approaches

      • C. R. Bartram, J. W. G. Janssen
      Pages 17-22

    5. Clinical Relevance of Cytogenetics in Acute Leukemia

      • A. Hagemeijer, D. C. van der Plas
      Pages 23-30

    6. Minimal Residual Disease in Acute Leukemia:Lessons Learned from Animal Models

      • A. Hagenbeek, A. C. M. Martens
      Pages 31-35

    7. Toward Improvement of Therapeutic Strategies in Leukemia by Amplification of the Immune Responses Against Leukemia

      • S. Slavin, A. Eckerstein, I. Hardan, M. Ben Shahar, R. Or, E. Naparstek et al.
      Pages 36-40

    8. Double Marker Analysis for Terminal Deoxynucleotidyl Transferase and Myeloid Antigens in Acute Nonlymphocytic Leukemia Patients and Healthy Subjects

      • H. J. Adriaansen, H. Hooijkaas, M. C. Kappers-Klunne, K. Hählen, M. B. van’t Veer, J. J. M. van Dongen
      Pages 41-49

    9. Antigen Receptor Rearrangement and Expression in Acute Leukemias

      • M. Volkmann, P. Mar, K. Pachmann, E. Thiel, B. Emmerich
      Pages 50-55

    10. Immunoglobulin and T-Cell Receptor Gene Rearrangements in Childhood Acute Lymphoblastic Leukemia and Non-Hodgkin’s Lymphoma

      • S. Schütt, K. Seeger, C. Schmidt, W. Siegert, G. Henze
      Pages 56-61

    11. Heterogeneity in Protein Patterns of CGL Blast Crisis Cells:Discrimination Between Lymphatic and Myeloic Lineages

      • I. Doxiadis, P. Dölken, M. E. Schneider, P. Wernet, H. Grosse-Wilde
      Pages 62-66

    12. Correlation Between the Expression of Myelomonocytic Surface Antigens and Ultrastructural Demonstration of Early Myeloperoxidase Expression in Null-AL(L) Cells

      • G. Heil, E. Gunsilius, A. N. Raghavachar, E. Kurrle, D. Hoelzer, H. Heimpel et al.
      Pages 67-71

    13. Interleukin-1 Production in Childhood Acute Lymphoblastic Leukemia During Chemo- and Radiotherapy According to BFM (Berlin-Frankfurt-Münster) Protocol

      • A. Chybicka, J. Boguslawska-Jaworska
      Pages 72-75

    14. Determination of Soluble Interleukin-2 Receptors After Bone Marrow Transplantation

      • W. Siegert, O. Josimovic-Alasevic, R. Schwerdtfeger, C. Schmidt, A. Neubauer, G. Henze et al.
      Pages 76-77

    15. Synergism of H2 Histamine Receptor Antagonists with Alpha-Interferon to Inhibit the Growth of Leukemic and Normal Hematopoietic Progenitors

      • D. Douer, I. Ben-Bassat, A. Kneller, S. D. Chitayat, N. Shaked, S. Salzberg et al.
      Pages 78-82

    16. Dependence of Serum Erythropoietin Level on Erythropoiesis in Leukemia

      • W. Jelkmann, H. Johannsen, G. Wiedemann, M. Otte, T. Wagner
      Pages 83-86

    17. Transferrin Derivatives with Growth Factor Activities in Acute Myeloblastic Leukemia:An Autocrine/Paracrine Pathway

      • K. H. Pflüger, A. Grüber, M. Welslau, H. Köppler, K. Havemann
      Pages 87-94

    18. In Vitro Effects of G-CSF, GM-CSF, and IL-3 on Leukemic Cells of Children with Acute Nonlymphoblastic Leukemia

      • C. Schrader, M. Reuter, K. Mempel, W.-D. Ludwig, H. Riehm, G. Schellong et al.
      Pages 95-97

    19. In Vitro Growth Kinetics of Myeloid Progenitor Cells of Myelodysplastic Patients in Response to Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-3

      • M. R. Schipperus, N. Vink, J. Lindemans, A. Hagemeijer, P. Sonneveld, J. Abels
      Pages 98-102
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Keywords

About this book

Acute leukemia a quite homogenous disease failed to break through the sound barriere of when untreated reveals a substantial hetero­ unsatisfactory cure rates even in special sub­ geneity in its response to therapy. While cure groups. While new protocols including more is achieved in a certain proportion of pa­ effective supportive care show some increase tients other cases prove to be highly resis­ in the initial response rates and certain im­ tant. The curability is superior in acute provements in the long-term results, no ben­ lymphoblastic (ALL) than in acute myeloid eficial effect on the relapse rate during the (AML) leukemia and - within both type- first 1 Y2 years emerged from any of these higher in children as compared to adults. regimens. Thus, high chances for cure are The two age groups and cell types can be presently restricted to children with ALL further subdivided into prognostic groups and to lesser proportions children with by special diagnostic features. Thus, in AML and adults with ALL and AML.

Editors and Affiliations

  • Departments of Internal Medicine and Pediatrics, University of Münster, Münster, Federal Republic of Germany

    T. Büchner, G. Schellong, W. Hiddemann, J. Ritter

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