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Consolidation Therapy with High-Dose Cytosine Arabinoside: Experiences of a Prospective Study in Acute Myeloid Leukemia

  • Conference paper
Acute Leukemias II

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 33))

Abstract

At the present time 60%-80% of adult patients suffering from acute myelogenous leukemia (AML) will achieve complete remission with the available induction chemotherapy including anthracycline antibiotics and cytosine arabinoside [1–5]. With standard chemotherapy, however, the majority of the patients will suffer leukemia relapse within the first 2 years after complete remission and only about 20% of the complete responders will have long-term disease-free survival. Substantially better results can be achieved with allogeneic bone marrow transplantation, which provides long-term remission in 50% or more of the patients who are transplanted in first remission with bone marrow grafts from histocompatible siblings [6, 7].

A study of the Süddeutsche Hämoblastosegruppe. The study was supported by the Deutsche Krebshilfe (contract M37/85 He2).

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Author information

Authors and Affiliations

  1. Dept. of Internal Medicine, University of Ulm, Germany

    E. Kurrle & G. Heil

  2. Dept. of Internal Medicine and Hematology, University of Tübingen, Germany

    G. Ehninger

  3. Internal Medicine, Zentralklinikum, 8900, Augsburg, Germany

    E. Fackler-Schwalbe & G. Schlimok

  4. Dept. of Hematology-Oncology, Hannover Medical School, Hannover, Germany

    M. Freund & H. Link

  5. Dept. of Internal Medicine, Hematology, University of Frankfurt/Main, Germany

    D. Hoelzer & P. S. Mitrou

  6. Robert-Bosch-Krankenhaus, 7000, Stuttgart, Germany

    B. Löffler

  7. Oncology Center, University, Mannheim, Germany

    A. Lösch & W. Queißer

  8. Dept. of Internal Medicine, Klinikum, Nürnberg, Germany

    S. Öhl & H. Wandt

Authors
  1. E. Kurrle
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  2. G. Ehninger
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  3. E. Fackler-Schwalbe
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  4. M. Freund
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  5. G. Heil
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  6. D. Hoelzer
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  7. H. Link
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  8. B. Löffler
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  9. A. Lösch
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  10. P. S. Mitrou
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  11. S. Öhl
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  12. W. Queißer
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  13. G. Schlimok
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  14. H. Wandt
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Editor information

Editors and Affiliations

  1. Departments of Internal Medicine and Pediatrics, University of Münster, Albert-Schweitzer-Straße 33, D-4400, Münster, Federal Republic of Germany

    T. Büchner , G. Schellong , W. Hiddemann  & J. Ritter , ,  & 

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© 1990 Springer-Verlag Berlin Heidelberg

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Kurrle, E. et al. (1990). Consolidation Therapy with High-Dose Cytosine Arabinoside: Experiences of a Prospective Study in Acute Myeloid Leukemia. In: Büchner, T., Schellong, G., Hiddemann, W., Ritter, J. (eds) Acute Leukemias II. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74643-7_46

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  • DOI: https://doi.org/10.1007/978-3-642-74643-7_46

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50984-4

  • Online ISBN: 978-3-642-74643-7

  • eBook Packages: Springer Book Archive

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