Therapy of Childhood Acute Nonlymphocytic Leukemia: The Pediatric Oncology Group Experience (1977–1988)

  • C. P. Steuber
  • S. J. Culbert
  • Y. Ravindranath
  • J. Krischer
  • A. Ragab
  • C. Civin
  • S. Inoue
  • F. Ruymann
  • B. Leventhal
  • R. Wilkinson
  • T. J. Vietti
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 33)

Abstract

In 1977, the members of the Pediatric Oncology Group (POG, formerly the Pediatric Division of the Southwest Oncology Group) initiated a series of protocols designed for the investigation and therapy of childhood acute nonlymphocytic leukemia (ANLL). In general, studies of childhood ANLL prior to the early 1970s were concerned primarily with induction response rates. Those studies usually employed single agents or drug combinations which had proven effective for the more frequently occurring acute lymphocytic leukemia of childhood.

Keywords

Leukemia Oncol Methotrexate Prednisone Etoposide 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Steuber CP (1981) Therapy in childhood acute nonlymphocytic leukemia (ANLL). Am J Pediatr Hematol Oncol 3: 379PubMedCrossRefGoogle Scholar
  2. 2.
    Freedman MH, Finklestein JZ, Hammond GD, Karon M (1971) The effect of chemotherapy on acute myelogenous leukemia in children. J Pediatr 78: 526PubMedCrossRefGoogle Scholar
  3. 3.
    George SL, Fernbach DJ, Vietti TJ et al. (1973) Factors influencing survival in pediatric acute leukemia. Cancer 32: 1542PubMedCrossRefGoogle Scholar
  4. 4.
    Gale RP (1979) Advances in the treatment of acute myelogenous leukemia. N Engl J Med 300: 1189PubMedCrossRefGoogle Scholar
  5. 5.
    Bennett JM, Catovsky D, Daniel MT et al. (1976) Proposals for the classification of the acute leukemias. Br J Haematol 33: 451PubMedCrossRefGoogle Scholar
  6. 6.
    Bennett JM, Catovsky D, Daniel M et al. (1985) Criteria for the diagnosis of acute leukemia of megakaryocyte lineage ( M7 ). Ann Intern Med 103: 460PubMedGoogle Scholar
  7. 7.
    Hewlett JS, Battle JD, Jr, Bishop RC et al. (1964) Phase II study of A-8103 (NSC-25154) in acute leukemia in adults. Cancer Chemother Rep 42: 25PubMedGoogle Scholar
  8. 8.
    Krischer JP, Steuber CP, Vietti TJ et al. (1989) Long term results in the treatment of acute non-lymphocytic leukemia. Med Pediatr Oncol 17: 401PubMedCrossRefGoogle Scholar
  9. 9.
    Steuber CP, Civin C, Culbert S et al. Therapy of childhood acute nonlymphocytic leukemia (ANLL) A Pediatric Oncology Group study, (in preparation)Google Scholar
  10. 10.
    Ravindranath Y, Krischer J, Steuber P et al. (1988) High dose arabinosyl cytosine (HdA) for induction and consolidation in childhood acute non-lymphocytic leukemia (ANLL) — A Pediatric Oncology Group study. International Society of Paediatric Oncology (SIOP), XX Meeting, Trondheim, Norway, Aug. 22–26, 1988, p 91 (abstract) published in: Med Pediatr Oncol 16: 408Google Scholar
  11. 11.
    Steuber CP, Humphrey GB, McMillan CW, Vietti TJ (1978) Remission induction in acute myelogenous leukemia using cytosine arabinoside synchronization. Med Pediatr Oncol 4: 337PubMedCrossRefGoogle Scholar
  12. 12.
    Lampkin BC, Masterson M, Sambrano JE et al. (1987) Current chemotherapeutic treatment strategies in childhood acute non-lymphocytic leukemia. Semin Oncol 14: 397PubMedGoogle Scholar
  13. 13.
    Woods WG, Ruymann F, Lampkin BC et al. (1987) Aggressive intensification treatment may abrogate the need for maintenance therapy in children with acute nonlymphocytic leukemia (ANLL). Blood 70 (Suppl l): 241a (abstract)Google Scholar
  14. 14.
    Kalwinski D, Mirro J, Jr, Schell M et al. (1988) Early intensification of chemotherapy for childhood acute nonlymphoblastic leukemia: improved remission induction with a five drug regimen including etoposide. J Clin Oncol 6: 1134Google Scholar
  15. 15.
    Creutig U, Ritter J, Riehm H et al. (1985) Improved results in childhood acute myelogenous leukemia: a report of the German cooperative study AML-BFM-78. Blood 65: 298Google Scholar
  16. 16.
    Grier HE, Gelber RD, Camitta BM et al. (1987) Prognostic factors in childhood acute myelogenous leukemia. J Clin Oncol 5: 1026PubMedGoogle Scholar
  17. 17.
    Hurd DD (1987) Allogeneic and autologous bone marrow transplantation for acute non-lymphocytic leukemia. Semin Oncol 14: 407PubMedGoogle Scholar
  18. 18.
    Chessels JM, O’Callaghan U, Hardesty RM (1986) Acute myeloid leukemia in childhood: clinical features and prognosis. Br J Haematol 63: 555CrossRefGoogle Scholar
  19. 19.
    Creutzig U, Ritter J, Schellong G (1988) Improved treatment results in the myelocytic subtypes FAB Ml -M4 due to intensification of induction therapy in the German AML- Study BFM-83. International Society of Paediatric Oncology (SIOP), XX Meeting Aug 1988 (abstract)Google Scholar
  20. 20.
    Odom LF, Gordon EM (1984) Acute monoblastic leukemia in infancy and early childhood: successful treatment with an epipodophyllotoxin. Blood 64: 875PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • C. P. Steuber
    • 1
  • S. J. Culbert
    • 2
  • Y. Ravindranath
    • 3
  • J. Krischer
    • 4
  • A. Ragab
    • 5
  • C. Civin
    • 6
  • S. Inoue
    • 3
  • F. Ruymann
    • 7
  • B. Leventhal
    • 6
  • R. Wilkinson
    • 8
  • T. J. Vietti
    • 9
  1. 1.Baylor College of MedicineHoustonUSA
  2. 2.M.D. Anderson Cancer CenterUniversity of TexasHoustonUSA
  3. 3.Children’s Hospital of MichiganDetroitUSA
  4. 4.Pediatric Oncology Group Statistical OfficeGainesvilleUSA
  5. 5.Emory University School of MedicineAtlantaUSA
  6. 6.Johns Hopkins UniversityBaltimoreUSA
  7. 7.Columbus Children’s HospitalColumbusUSA
  8. 8.Cancer Center of HawaiiUniversity of San DiegoHonoluluUSA
  9. 9.Washington University Medical CenterSt. LouisUSA

Personalised recommendations