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Prognostic Significance of the Karyotype in Patients with Primary Myelodysplastic Syndrome

  • Conference paper
Acute Leukemias II

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 33))

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Abstract

The myelodysplastic syndrome (MDS) comprises a group of heterogeneous hematologic disorders characterized by ineffective hematopoiesis and a high risk of transformation to acute leukemia. Studies on the role of chromosomes in MDS are still controversial as contrasted with those in acute non-lymphocytic leukemia (ANLL), where specific translocations have been associated with certain morphologic types [1]. Only a few reports described cytogenetic findings in a significant number of patients with MDS [2–4]. The purpose of this study was to determine the frequency of chromosome anomalies in a large series of patients with primary MDS, their correlation with morphologic subtypes, and prognostic impact.

This study was supported by the Deutsche Forschungsgemeinschaft

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Authors and Affiliations

  1. Department of Internal Medicine, Oncology and Hematology, University, Hamburg, Germany

    S. Suciu, H. J. Weh & D. K. Hossfeld

Authors
  1. S. Suciu
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  2. H. J. Weh
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  3. D. K. Hossfeld
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Editors and Affiliations

  1. Departments of Internal Medicine and Pediatrics, University of Münster, Albert-Schweitzer-Straße 33, D-4400, Münster, Federal Republic of Germany

    T. Büchner , G. Schellong , W. Hiddemann  & J. Ritter , ,  & 

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© 1990 Springer-Verlag Berlin Heidelberg

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Suciu, S., Weh, H.J., Hossfeld, D.K. (1990). Prognostic Significance of the Karyotype in Patients with Primary Myelodysplastic Syndrome. In: Büchner, T., Schellong, G., Hiddemann, W., Ritter, J. (eds) Acute Leukemias II. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74643-7_32

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  • DOI: https://doi.org/10.1007/978-3-642-74643-7_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50984-4

  • Online ISBN: 978-3-642-74643-7

  • eBook Packages: Springer Book Archive

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