Abstract
Cytogenetic analysis has become an important factor in the characterization of a leukemic cell population in addition to morphological, immunological, and cytochemical criteria [1]. Blast cells of patients with acute nonlymphoblastic leukemia (ANLL) show specific karyotypic changes, which are of diagnostic and probably prognostic value concerning the course of the disease. We report here the cytogenetic investigation of children with ANLL during a 5-year period (January 1984 – December 1988). Most of the patients were treated according to the protocol of the AML-BFM study group.
Supported by the Kind-Philipp-Stiftung and the Parents’ Initiative Giessen
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Meeting Report (1988) Morphologic, immunologic and cytogenetic (MIC) working classification of the acute myeloid leukaemias. Br J Haematol 68:487–494
Seabright M (1971) A rapid banding technique for human chromosomes. Lancet ii:971–972
ISCN (1985) An international system for human cytogenetic nomenclature. Birth defects:original article series, 21. March of Dimes Birth Defects Foundation, New York
First International Workshop on Chromosomes in Leukemia (1978) Chromosomes in acute non-lymphocytic leukemia. Br J Haematol 39:311–316
Bloomfield CD, de la Chapelle A (1987) Chromosome abnormalities in acute non-lymphocytic leukemia:clinical and biologic significance. Semin Oncol 14:372–383
Weh HJ, Kuse R, Hoffmann R, Seeger D, Su- ciu S, Kabisch H, Ritter J, Hossfeld DK (1988) Prognostic significance of chromosome analysis in de novo acute myeloid leukemia ( AML ). Blut 56:19–26
Rowley JD, Alimena E, Hagemeijer A, Mitelman F, Prigogina EL (1982) A collaborative study of the relationship of the morphological type of acute nonlymphocytic leukemia with patient age and karyotype. Blood 59:1013–1022
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© 1990 Springer-Verlag Berlin Heidelberg
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Ritterbach, J., Harbott, J., Ritter, J., Lampert, F. (1990). Chromosomal Aberrations in Childhood Acute Nonlymphoblastic Leukemia. In: Büchner, T., Schellong, G., Hiddemann, W., Ritter, J. (eds) Acute Leukemias II. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74643-7_29
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DOI: https://doi.org/10.1007/978-3-642-74643-7_29
Publisher Name: Springer, Berlin, Heidelberg
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