Abstract
Leukemia is thought to be the clonal expansion of a single mutated cell. Depending on the differentiation stage of this cell, different cell lineages might be involved in tumorigenesis. Keinänen et al. [2] have shown that myeloid, erythrocytic, and megakaryocytic lineages were involved in 8 out of 12 cases of acute myeloid leukemia with monosomy 7 or trisomy 8. In order to evaluate the lineage involvement in a case of acute monocytic leukemia with trisomy 8 and a translocation t(1;11), we modified a method described by Teerenhovi et al. [1]. With this method it is possible to analyze cell surface antigens and chromosomes of the same cell, whereas by standard chromosome preparation the cell membrane and cytoplasmic structures are destroyed.
This project was supported by the Deutsche Forschungsgemeinschaft, Schwerpunktprogramm Klassische und molekulare Tumorzytogenetik.
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References
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Nölle, I., Schlegelberger, B., Schmitz, N., Bödewadt-Radzun, S., Grote, W. (1990). Acute Monocytic Leukemia with Translocation t(1;11) (p31;q23):Simultaneous Staining of Chromosomes and Cell Surface Antigens. In: Büchner, T., Schellong, G., Hiddemann, W., Ritter, J. (eds) Acute Leukemias II. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74643-7_27
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DOI: https://doi.org/10.1007/978-3-642-74643-7_27
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