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Pharmacokinetics of Folinic Acid in Children with Acute Lymphoblastic Leukemia

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Acute Leukemias II

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 33))

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Abstract

We analyzed folinic acid (FA) levels in the serum samples of 20 children with acute lymphoblastic leukemia (ALL). Mean age of the patients was 7.7 years (SD, 3.96 years), median age 6.8 years, and range 2.6–17.4 years. The patients received 96 infusions of methotrexate (MTX) at a dose of 8 g/m2. A total of 320 serum samples — taken during different periods of rescue therapy — were analyzed. Determination of MTX, 7-OH-MTX, and FA levels was performed by high-performance liquid chromatography (HPLC) with electrochemical detection.

Grants from the Norwegian Cancer Society (Norsk Kreftforeningen) and The Cancer Fund of the Regional Hospital in Trondheim (RIT Kreftfondet) enabled us to perform the research presented here.

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Authors and Affiliations

  1. Dept. of Pediatrics and Clinical Chemistry, University of Trondheim, Norway

    J. D. Borsi, E. Sagen, I. Romslo & P. J. Moe

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  1. J. D. Borsi
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  2. E. Sagen
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  3. I. Romslo
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  4. P. J. Moe
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Editors and Affiliations

  1. Departments of Internal Medicine and Pediatrics, University of Münster, Albert-Schweitzer-Straße 33, D-4400, Münster, Federal Republic of Germany

    T. Büchner , G. Schellong , W. Hiddemann  & J. Ritter , ,  & 

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© 1990 Springer-Verlag Berlin Heidelberg

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Borsi, J.D., Sagen, E., Romslo, I., Moe, P.J. (1990). Pharmacokinetics of Folinic Acid in Children with Acute Lymphoblastic Leukemia. In: Büchner, T., Schellong, G., Hiddemann, W., Ritter, J. (eds) Acute Leukemias II. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74643-7_21

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  • DOI: https://doi.org/10.1007/978-3-642-74643-7_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50984-4

  • Online ISBN: 978-3-642-74643-7

  • eBook Packages: Springer Book Archive

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