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In Vitro Effects of G-CSF, GM-CSF, and IL-3 on Leukemic Cells of Children with Acute Nonlymphoblastic Leukemia

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Acute Leukemias II

Abstract

Hematopoietic growth factors (G-CSF, GM-CSF, and IL-3) are potent stimulators of proliferation and differentiation of normal myelopoiesis in vitro and in vivo [1]. To study the effects of G-CSF, GM-CSF, and IL-3 on proliferation of leukemic cells of children with acute nonlymphoblastic leukemia (ANLL), we investigated peripheral blood (PB) and bone marrow (BM) cells of 20 children with ANLL. Furthermore, we studied production of G-CSF by leukemic cells.

C.S. is an MD scholarship recipient of the Kind-Philipp-Stiftung für Leukämieforschung.

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© 1990 Springer-Verlag Berlin Heidelberg

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Schrader, C. et al. (1990). In Vitro Effects of G-CSF, GM-CSF, and IL-3 on Leukemic Cells of Children with Acute Nonlymphoblastic Leukemia. In: Büchner, T., Schellong, G., Hiddemann, W., Ritter, J. (eds) Acute Leukemias II. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74643-7_17

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  • DOI: https://doi.org/10.1007/978-3-642-74643-7_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50984-4

  • Online ISBN: 978-3-642-74643-7

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