Induction of Lymphokine-Activated Killer (LAK) Cells Against Human Leukemia Cells
Lymphokine-activated killer (LAK) cells are known to lyse fresh solid tumor cells in vitro , and clinical studies suggest that adoptive immunotherapy with LAK cells and interleukin-2 (IL-2) may be a promising approach in the treatment of solid tumors [2, 3]. As only few data are available on the LAK cell system in connection with human leukemia [4, 5], we investigated the induction of LAK cells against human leukemia cells in vitro and studied the augmentation of cytotoxic mechanisms which may be achieved by the combined application of different lymphokines or the coculturing of effector cells with tumor cells.
KeywordsToxicity Chromate Lymphoma Leukemia Dition
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