You see things, and sa)' why? But I dream 1hings that never were, and I say, 11'hy 110t? George Bernhard Shaw Far ahead of his time, June 1st, 1909, Alexander Maximov communicated in a lecture, given in the Charite in Berlin, the fundamental knowledge, that there exists a lymphoid hemopoetic stem cell. Alexander Friedenstein explained that during the following years, Maximov also showed that the idea of interaction between hemopoetic cells and their stroma to be one of the most significant experiences. Monoclonal antibodies, recombinant DNA technics and the improvement of tissue culture models are the major developments to improve our possibilities to clarify growth and differentiation functions of hemopoetic cells. During the last two decades it was shown that soluble products, released from T cells, were not only involved in inducing B cells to produce specific immunoglobulin secretion after antigen stimulation. Furthermore, lymphokines together with other cytokines regulate the growth and differentiation of hemopoetic cells. As I have learned from Dick Gershon, our knowledge of the cellular basis for immunoregulation has come a long way since 450 B.C. Thucydides comments on the possible role of immune response in controlling the Black Death. Dick Gershon speculated that no scientific interest for these interesting observations was put forth at that time. Perhaps the problems, the Athenians were having with the Spartans, converted money from basis research into the military budget.
Editors and Affiliations
Medizinische Klinik, Abteilung für klinische Chemie, Universitäts-Krankenhaus Eppendorf, Germany
Rolf Neth
Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, USA
Robert C. Gallo
Chester Beatty Laboratories, Leukemia Research Fund Centre, Institute of Cancer Research, London, UK
Melvyn F. Greaves
Abteilung Pädiatrie II, Universitätskinderklinik und Poliklinik Ulm, Ulm, Germany
Gerhard Gaedicke
Universität Ulm, Ulm, Germany
Gerhard Gaedicke
Labor für Hautimmunologie, Bioverträglichkeit-Immunologie, Paul-Gerson-Unna-Forschungszentrum, Beiersdorf-AG, Germany
Sven Gohla
Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Germany
Klaus Mannweiler
Abteilung Hämatologie und Onkologie, Kinderklinik und Poliklinik der Westfälischen Wilhelms-Universität, Münster, Germany
Jörg Ritter
Bibliographic Information
Book Title: Modern Trends in Human Leukemia VIII
Book Subtitle: New Results in Clinical and Biological Research Including Pediatric Oncology
Editors: Rolf Neth, Robert C. Gallo, Melvyn F. Greaves, Gerhard Gaedicke, Sven Gohla, Klaus Mannweiler, Jörg Ritter