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The Use of Long-term Bone Marrow Cultures (LTBMC) to Detect Hematotoxic Side Effects of Purging Methods

  • Conference paper
Modern Trends in Human Leukemia VIII

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 32))

  • 92 Accesses

Abstract

The development of suitable methods for the purging of malignant bone marrow contaminating cells in patients with acute leukemia may offer a better chance of success for autologous bone marrow transplantation. In addition to investigating the wanted effect, i.e., damage to leukemic cells, it is important to investigate the tolerance of normal hematopoietic stem cells within these manipulations in order to guarantee the grafting of the purged transplants.

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References

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Division of Hematology and Oncology, Karl-Marx-University, 7010, Leipzig, German Democratic Republic

    E. Schulze, W. Helbig & U. Hofmann

Authors
  1. E. Schulze
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  2. W. Helbig
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  3. U. Hofmann
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Editor information

Editors and Affiliations

  1. Medizinische Klinik, Abteilung für klinische Chemie, Universitäts-Krankenhaus Eppendorf, Martinistraße 52, 2000, Hamburg 20, Germany

    Rolf Neth

  2. Laboratory of Tumor Cell Biology, National Cancer Institute, 20892, Bethesda, MD, USA

    Robert C. Gallo

  3. Chester Beatty Laboratories, Leukemia Research Fund Centre, Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK

    Melvyn F. Greaves

  4. Abteilung Pädiatrie II, Universitätskinderklinik und Poliklinik Ulm, Prittwitzstr. 43, 7900, Ulm, Germany

    Gerhard Gaedicke

  5. Universität Ulm, Prittwitzstr. 43, 7900, Ulm, Germany

    Gerhard Gaedicke

  6. Labor für Hautimmunologie, Bioverträglichkeit-Immunologie, Paul-Gerson-Unna-Forschungszentrum, Beiersdorf-AG, Unnastr. 48, 2000, Hamburg 20, Germany

    Sven Gohla

  7. Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Martinistr. 52, 2000, Hamburg 20, Germany

    Klaus Mannweiler

  8. Abteilung Hämatologie und Onkologie, Kinderklinik und Poliklinik der Westfälischen Wilhelms-Universität, Albert-Schweitzer-Str. 33, 4400, Münster, Germany

    Jörg Ritter

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© 1989 Springer-Verlag Berlin Heidelberg

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Cite this paper

Schulze, E., Helbig, W., Hofmann, U. (1989). The Use of Long-term Bone Marrow Cultures (LTBMC) to Detect Hematotoxic Side Effects of Purging Methods. In: Neth, R., et al. Modern Trends in Human Leukemia VIII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74621-5_6

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  • DOI: https://doi.org/10.1007/978-3-642-74621-5_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50967-7

  • Online ISBN: 978-3-642-74621-5

  • eBook Packages: Springer Book Archive

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