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Current Issues and Future Directions in Marrow Transplantation

  • Conference paper
Modern Trends in Human Leukemia VIII

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 32))

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Abstract

The use of allogeneic marrow transplantation as treatment for patients with various hematological diseases has increased in recent years [1–6]. A survey by the International Bone Marrow Transplantation Registry [7] estimated the number of transplants carried out through the year 1987 to be in the order of 20000, more than 10000 of these during the years of 1985 through 1987. Marrow transplantation has been employed in most cases (≥ 80%) for therapy of malignant hematologic diseases. Roughly 10% of all transplants have been for the treatment of patients with acquired or inherited marrow dysfunction (aplastic anemia), and 5%–6% have been for treatment of congenital defects of the hematopoietic and immune systems (thalassemia major, severe combined immuno-deficiency disease, and other inborn errors).

Supported in part by grant HL 36444 from the National Heart, Lung and Blood Institute, and by grants CA 18029, CA 18221, CA 31787, CA 18105 and CA 15704 awarded by the National Cancer Institute, National Institutes of Health, DHHS

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References

  1. Gratwohl A, Hermans J, Barrett AJ, Ernst P, Frassoni F, Gahrton G, Granena A, Kolb HJ, Marmont A, Prentice HG, Speck B, Vernant JP, Zwaan FJ (1988) Allogeneic bone marrow transplantation for leukaemia in Europe: report from the working party on leukaemia, European Group for Bone Marrow Transplantation. Lancet 1: 1379–1382

    Google Scholar 

  2. Ringden O, Zwaan F, Hermans J, Gratwohl A (1987) for the Leukemia Working Party of the European Group for Bone Marrow Transplantation. European experience of bone marrow transplantation for leukemia. Transplant Proc 19: 2600–2604

    PubMed  CAS  Google Scholar 

  3. Champlin R (1987) for the Advisory Committee of the International Bone Marrow Transplant Registry. Bone marrow transplantation for acute leukemia: a preliminary report from the International Bone Marrow Transplant Registry. Transplant Proc 19: 2626–2628

    Google Scholar 

  4. Gluckman E (1987) Current status of bone marrow transplantation for severe aplastic anemia: a preliminary report from the International Bone Marrow Transplant Registry. Transplant Proc 19: 2597–2599

    PubMed  CAS  Google Scholar 

  5. Storb R, Doney K, Thomas ED, Anasetti C, Appelbaum F, Beatty P, Bensinger W, Buckner CD, Clift R, Fefer A, Hansen J, Hill R, Martin P, McGuffin R, Sanders J, Singer J, Stewart P, Sullivan K, Whitherspoon R (1988) Allogeneic and syngeneic marrow transplantation for aplastic anemia: overview of Seattle results. In: Baum SJ, Santos GW, Takaku F (eds) Experimental hematology today-1987. Recent advances and future directions in bone marrow transplantation. Springer, Berlin Heidelberg New York, pp 119–124

    Chapter  Google Scholar 

  6. Storb R (1987) Critical issues in bone marrow transplantation. Transplant Proc 19: 2774–2781

    PubMed  CAS  Google Scholar 

  7. Bortin MM (1988) Key results from recent analyses: a report from the International Bone Marrow Transplant Registry. Proceedings of the 17th annual meeting of the International Society for Experimental Hematology, Houston Tex, August 21–25. Exp Hematol 16:414, Abstr #7

    Google Scholar 

  8. Thomas ED, Storb R, Clift RA, Fefer A, Johnson FL, Neiman PE, Lerner KG, Glucksberg H, Buckner CD (1975) Bonemarrow transplantation. N Engl J Med 292:832–843, 895–902

    Article  PubMed  CAS  Google Scholar 

  9. Lucarelli G, Galimberti M, Polchi P, Giardini C, Politi P, Baronciani D, Angelucci E, Manenti F, Delfini C, Aureli G, Muretto P (1987) Marrow transplantation in patients with advanced thalassemia. N Engl J Med 316: 1050–1055

    Article  PubMed  CAS  Google Scholar 

  10. O’Reilly RJ (1983) Allogeneic bone marrow transplantation: current status and future directions. Blood 62: 941–964

    PubMed  Google Scholar 

  11. Brochstein J A, Kernan NA, Groshen S, Cirrincione C, Shank B, Emanuel D, Laver J, O’Reilly RJ (1987) Allogeneic bone marrow transplantation after hyperfractionated total-body irradiation and cyclophosphamide in children with acute leukemia. N Engl J Med 317: 1618–1624

    Article  PubMed  CAS  Google Scholar 

  12. Goldman JM, Apperley JF, Jones L, Marcus R, Goolden AWG, Batchelor R, Hale G, Waldmann H, Reid CD, Hows J, Gordon-Smith E, Catovsky D, Galton DAG (1986) Bone marrow transplantation for patients with chronic myeloid leukemia. N Engl J Med 314: 202–207

    Article  PubMed  CAS  Google Scholar 

  13. Dinsmore R, Kirkpatrick D, Flomenberg N, Gulati S, Kapoor N, Shank B, Reid A, Groshen S, O’Reilly RJ (1983) Allogeneic bone marrow transplantation for patients with acute lymphoblastic leukemia. Blood 62: 381–388

    PubMed  CAS  Google Scholar 

  14. Santos GW, Tutschka PJ, Brookmeyer R, Saral R, Beschorner WE, Bias WB, Braine HG, Burns WH, Elfenbein GJ, Kaizer H, Mellits D, Sensenbrenner LL, Stuart RK, Yeager AM (1983) Marrow transplantation for acute nonlymphocytic leukemia after treatment with busulfan and cyclophosphamide. N Engl J Med 309: 1347–1353

    Article  PubMed  CAS  Google Scholar 

  15. Gale RP, Bortin MM, Van Bekkum DW, Biggs JC, Dicke KA, Gluckman E, Good RA, Hoffmann RG, Kay HEM, Kersey JH, Marmont A, Masaoka T, Rimm AA, Van Rood JJ, Zwaan FE (1987). Risk factors for acute graft-versus-host disease. Br J Haematol 67: 397–406

    Article  PubMed  CAS  Google Scholar 

  16. Thomas ED, Clift RA, Fefer A, Appelbaum FR, Beatty PG, Bensinger WI, Buckner CD, Cheever MA, Deeg HJ, Doney K, Flournoy N, Greenberg P, Hansen JA, Martin P, McGuffm R, Ram-berg R, Sanders JE, Singer J, Stewart P, Storb R, Sullivan K, Weiden PL, Witherspoon R (1986) Marrow transplantation for the treatment of chronic myelogenous leukemia. Ann Intern Med 104: 155–163

    PubMed  CAS  Google Scholar 

  17. Thomas ED, Buckner CD, Clift RA, Fefer A, Johnson FL, Neiman PE, Sale GE, Sanders JE, Singer JW, Shulman H, Storb R, Weiden PL (1979) Marrow transplantation for acute nonlymphoblastic leukemia in first remission. N Engl J Med 301: 597–599

    Article  PubMed  CAS  Google Scholar 

  18. Thomas ED, Sanders JE, Flournoy N, Johnson FL, Buckner CD, Clift RA, Fefer A, Goodell BW, Storb R, Weiden P (1979) Marrow transplantation for patients with acute lymphoblastic leukemia in remission. Blood 54: 468–476

    PubMed  CAS  Google Scholar 

  19. Appelbaum FR, Dahlberg S, Thomas ED, Buckner CD, Cheever MA, Clift RA, Crowley J, Deeg HJ, Fefer A, Greenberg P, Kadin M, Smith W, Stewart P, Sullivan KM, Storb R, Weiden P (1984) Bone marrow transplantation or chemotherapy after remission induction for adults with acute nonlymphoblastic leukemia: a prospective comparison. Ann Intern Med 101: 581–588

    PubMed  CAS  Google Scholar 

  20. Clift RA, Buckner CD, Thomas ED, Kopecky KJ, Appelbaum FR, Tallman M, Storb R, Sanders J, Sullivan K, Banaji M, Beatty P, Bensinger W, Cheever M, Deeg J, Doney K, Fefer A, Greenberg P, Hansen JA, Hackman R, Hill R, Martin P, Meyers J, McGuffm R, Neiman P, Sale G, Shulman H, Singer J, Stewart P, Weiden P, Witherspoon R (1987) The treatment of acute nonlymphoblastic leukemia by allogeneic marrow transplantation. Bone Marrow Transplant 2: 243–258

    PubMed  CAS  Google Scholar 

  21. Storb R, Thomas ED, Buckner CD, Appelbaum FR, Clift RA, Deeg HJ, Doney K, Hansen JA, Prentice RL, Sanders JE, Stewart P, Sullivan KM, Witherspoon RP (1984) Marrow transplantation for aplastic anemia. Semin Hematol 21: 27–35

    PubMed  CAS  Google Scholar 

  22. Storb R, Thomas ED (1985) Graft-vs-host disease in dog and man: The Seattle experience. In: Moller G (ed) Immunological reviews, No. 88. Copenhagen, Munksgaard, 215–238

    Google Scholar 

  23. Meyers JD (1988) Prevention and treatment of cytomegalovirus infection after marrow transplantation. Bone Marrow Transplant 3: 95–104

    PubMed  CAS  Google Scholar 

  24. Storb R, Deeg HJ, Fisher LD, Appelbaum F, Buckner CD, Bensinger W, Clift R, Doney K, Irle C, McGuffm R, Martin P, Sanders J, Schoch G, Singer J, Stewart P, Sullivan K, Witherspoon R, Thomas ED (1988) Cyclosporine versus methotrexate for graft-versus-host disease prevention in patients given marrow grafts for leukemia: long-term follow-up of three controlled trials. Blood 71: 293–298

    PubMed  CAS  Google Scholar 

  25. Storb R, Deeg H J, Whitehead J, Appelbaum F, Beatty P, Bensinger W, Buckner CD, Clift R, Doney K, Farewell V, Hansen J, Hill R, Lum L, Martin P, McGuffm R, Sanders J, Stewart P, Sullivan K, Witherspoon R, Yee G, Thomas ED (1986) Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemia. N Engl J Med 314: 729–735

    Article  PubMed  CAS  Google Scholar 

  26. Storb R, Deeg HJ, Farewell V, Doney K, Appelbaum F, Beatty P, Bensinger W, Buckner CD, Clift R, Hansen J, Hill R, Longton G, Lum L, Martin P, McGuffin R, Sanders J, Singer J, Stewart P, Sullivan K, Witherspoon R, Thomas ED (1986) Marrow transplantation for severe aplastic anemia: methotrexate alone compared with a combination of methotrexate and cyclosporine for prevention of acute graft-versus-host disease. Blood 68: 119–125

    PubMed  CAS  Google Scholar 

  27. Sullivan KM, Witherspoon R, Storb R, Appelbaum F, Beatty P, Bensinger W, Bigelow C, Buckner CD, Cheever M, Clift R, Doney K, Fefer A, Greenberg P, Hansen J, Martin P, Matthews D, McDonald G, Meyers J, Petersen FB, Sanders J, Shulman H, Singer J, Stewart P, Thomas ED (1988) Chronic graft-versus-host disease: pathogenesis, diagnosis, treatment and prognostic factors. In: Baum SJ, Santos GW, Takaku F (eds) Experimental hematology today-1987. Recent advances and future directions in bone marrow transplantation. Springer, Berlin Heidelberg New York, pp 150–157

    Chapter  Google Scholar 

  28. Butturini A, Franceschini F, Gale RP (1988) Critical analysis of T-cell depletion in man. In: Martelli MF, Grignani F, Reisner Y (eds) T-cell depletion in allogeneic bone marrow transplantation. Ares-Serono symposia, Rome, pp 1–13

    Google Scholar 

  29. Goldman JM, Gale RP, Horowitz MM, Biggs JC, Champlin RE, Gluckman E, Hoffmann RG, Jacobsen SJ, Marmont AM, McGlave PB, Messner HA, Rimm AA, Rozman C, Speck B, Tura S, Weiner RS, Bortin MM (1988) Bone marrow transplantation for chronic myelogenous leukemia in chronic phase: increased risk for relapse associated with T-cell depletion. Ann Intern Med 108: 806–814

    PubMed  CAS  Google Scholar 

  30. Gordon-Smith EC (1987) Recent advances and future trends in bone marrow transplantation for severe aplastic anemia. In: Baum SJ, Santos GW, Takaku F (eds) Experimental hematology today-1987. Recent advances and future directions in bone marrow transplantation. Springer, Berlin Heidelberg New York, pp 125–129

    Google Scholar 

  31. Deeg H J, Aprile J, Storb R, Graham T, Hackman R, Appelbaum F, Schuening F (1988) Functional dendritic cells are required for transfusion-induced sensitization in canine marrow graft recipients. Blood 71: 1138–1140

    PubMed  CAS  Google Scholar 

  32. Deeg HJ, Aprile J, Graham TC, Appelbaum FR, Storb R (1986) Ultraviolet irradiation of blood prevents transfusion-induced sensitization and marrow graft rejection in dogs. Concise report. Blood 67: 537–539

    PubMed  CAS  Google Scholar 

  33. Thomas ED, Clift RA, Hersman J, Sanders JE, Stewart P, Buckner CD, Fefer A, McGuffln R, Smith JW, Storb R (1982) Marrow transplantation for acute non-lymphoblastic leukemia in first remission using fractionated or single-dose irradiation. Int J Radiat Oncol Biol Phys 8: 817–821

    PubMed  CAS  Google Scholar 

  34. Tutschka PJ, Copelan EA, Klein JP (1987) Bone marrow transplantation for leukemia following a new busulfan and cyclophosphamide regimen. Blood 70: 1382–1388

    PubMed  CAS  Google Scholar 

  35. Appelbaum FR, Badger C, Deeg HJ, Nelp WB, Storb R (1987) Use of iodine-131-labeled anti-immune response-associated monoclonal antibody as a preparative regimen prior to bone marrow transplantation: initial dosimetry. NCI Monogr 3: 67–71

    PubMed  Google Scholar 

  36. Appelbaum FR, Brown PA, Graham TC, Sandmaier BM, Schuening FW, Storb R (1988) Characterization of malignant lymphoma in dogs and use as a model for the development of treatment strategies. In: Baum SJ, Santos GW, Takaku F (eds) Experimental hematology today-1987. Recent advances and future directions in bone marrow transplantation. Springer, Berlin Heidelberg New York, pp 31–35

    Chapter  Google Scholar 

  37. Meyers JD, Flournoy N, Thomas ED (1982) Nonbacterial pneumonia after allogeneic marrow transplantation: a review of ten years’ experience. Rev Infect Dis 4: 1119–1132

    Article  PubMed  CAS  Google Scholar 

  38. Winston DJ, Ho WG, Champlin RE, Gale RP (1984) Infectious complications of bone marrow transplantation. Exp Hematol 12: 205–215

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Fred Hutchinson Cancer Research Center, 1124 Columbia St., 98104, CA, USA

    R. Storb

  2. University of Washington School of Medicine, 1124 Columbia St., 98104, CA, USA

    R. Storb

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  1. R. Storb
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Editors and Affiliations

  1. Medizinische Klinik, Abteilung für klinische Chemie, Universitäts-Krankenhaus Eppendorf, Martinistraße 52, 2000, Hamburg 20, Germany

    Rolf Neth

  2. Laboratory of Tumor Cell Biology, National Cancer Institute, 20892, Bethesda, MD, USA

    Robert C. Gallo

  3. Chester Beatty Laboratories, Leukemia Research Fund Centre, Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK

    Melvyn F. Greaves

  4. Abteilung Pädiatrie II, Universitätskinderklinik und Poliklinik Ulm, Prittwitzstr. 43, 7900, Ulm, Germany

    Gerhard Gaedicke

  5. Universität Ulm, Prittwitzstr. 43, 7900, Ulm, Germany

    Gerhard Gaedicke

  6. Labor für Hautimmunologie, Bioverträglichkeit-Immunologie, Paul-Gerson-Unna-Forschungszentrum, Beiersdorf-AG, Unnastr. 48, 2000, Hamburg 20, Germany

    Sven Gohla

  7. Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Martinistr. 52, 2000, Hamburg 20, Germany

    Klaus Mannweiler

  8. Abteilung Hämatologie und Onkologie, Kinderklinik und Poliklinik der Westfälischen Wilhelms-Universität, Albert-Schweitzer-Str. 33, 4400, Münster, Germany

    Jörg Ritter

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© 1989 Springer-Verlag Berlin Heidelberg

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Storb, R. (1989). Current Issues and Future Directions in Marrow Transplantation. In: Neth, R., et al. Modern Trends in Human Leukemia VIII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74621-5_5

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  • DOI: https://doi.org/10.1007/978-3-642-74621-5_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50967-7

  • Online ISBN: 978-3-642-74621-5

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