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Interactions Between Hematopoietic Growth Factors: The Clinical Role of Combination Biotherapy

  • Conference paper
Modern Trends in Human Leukemia VIII

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 32))

Abstract

The Frederick Stohlman Memorial Lectures have, over the years, reflected the progression of leukemia research in areas initially thought to be as diverse as retrovirology/oncogenes, chemotherapy/immunotherapy, and hematopoietic growth factors. At the Seventh Wilsede Meeting we heard how convergent these areas were. The polypeptide growth factors which affect lymphohematopoietic cell proliferation and differentiation have expanded to at least 11 distinct gene products with pleiotropic and overlapping functions (G-, GM-, M-CSF, erythropoietin, and interleukins 1–7 [1], The early characterization of hematopoietic growth factors was based on their ability to stimulate the clonal proliferation of human bone marrow progenitor cells. In addition, these factors were shown to activate a variety of functions of mature lymphoid and hematopoietic cells.

Supported by grants CA 20194, CA 32156, and CA 31780 from the National Cancer Institute; American Cancer Society Grant CH-3K, and the Gar Reichman Foundation.

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Author information

Authors and Affiliations

  1. The James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, 10021, New York, NY, USA

    M. A. S. Moore

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  1. M. A. S. Moore
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Editor information

Editors and Affiliations

  1. Medizinische Klinik, Abteilung für klinische Chemie, Universitäts-Krankenhaus Eppendorf, Martinistraße 52, 2000, Hamburg 20, Germany

    Rolf Neth

  2. Laboratory of Tumor Cell Biology, National Cancer Institute, 20892, Bethesda, MD, USA

    Robert C. Gallo

  3. Chester Beatty Laboratories, Leukemia Research Fund Centre, Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK

    Melvyn F. Greaves

  4. Abteilung Pädiatrie II, Universitätskinderklinik und Poliklinik Ulm, Prittwitzstr. 43, 7900, Ulm, Germany

    Gerhard Gaedicke

  5. Universität Ulm, Prittwitzstr. 43, 7900, Ulm, Germany

    Gerhard Gaedicke

  6. Labor für Hautimmunologie, Bioverträglichkeit-Immunologie, Paul-Gerson-Unna-Forschungszentrum, Beiersdorf-AG, Unnastr. 48, 2000, Hamburg 20, Germany

    Sven Gohla

  7. Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Martinistr. 52, 2000, Hamburg 20, Germany

    Klaus Mannweiler

  8. Abteilung Hämatologie und Onkologie, Kinderklinik und Poliklinik der Westfälischen Wilhelms-Universität, Albert-Schweitzer-Str. 33, 4400, Münster, Germany

    Jörg Ritter

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© 1989 Springer-Verlag Berlin Heidelberg

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Moore, M.A.S. (1989). Interactions Between Hematopoietic Growth Factors: The Clinical Role of Combination Biotherapy. In: Neth, R., et al. Modern Trends in Human Leukemia VIII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74621-5_2

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  • DOI: https://doi.org/10.1007/978-3-642-74621-5_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50967-7

  • Online ISBN: 978-3-642-74621-5

  • eBook Packages: Springer Book Archive

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