Immunologic Subclassification of Acute Lymphoblastic Leukemia in Childhood and Prognosis (Modified BFM Protocol)
Acute lymphoblastic leukemias (ALLs) in childhood are clonal proliferations of lymphoid cells. It is now possible precisely to define stages of human lymphocyte differentiation using more traditional cell markers such as surface membrane immunoglobulin (SIg), sheep erythrocyte receptor (E), and cytochemical stains or highly specific monoclonal antibodies. The application of these immunologic methods to the study of ALL has further confirmed the heterogeneous nature of this disease. There appear to be clinical differences among the immunologic subtypes. It is as yet unclear whether T-cell disease is an independent prognostic variable. In the past B-cell ALL was characterized by an extremely poor prognosis. Relatively little information is available regarding the prognosis of the various stages of pre-B-ALL and T- ALL.
KeywordsAcute Lymphoblastic Leukemia Clonal Proliferation High White Blood Cell Count Independent Prognostic Variable Product Limit Estimate
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