Immunologic Subclassification of Acute Lymphoblastic Leukemia in Childhood and Prognosis (Modified BFM Protocol)
Acute lymphoblastic leukemias (ALLs) in childhood are clonal proliferations of lymphoid cells. It is now possible precisely to define stages of human lymphocyte differentiation using more traditional cell markers such as surface membrane immunoglobulin (SIg), sheep erythrocyte receptor (E), and cytochemical stains or highly specific monoclonal antibodies. The application of these immunologic methods to the study of ALL has further confirmed the heterogeneous nature of this disease. There appear to be clinical differences among the immunologic subtypes. It is as yet unclear whether T-cell disease is an independent prognostic variable. In the past B-cell ALL was characterized by an extremely poor prognosis. Relatively little information is available regarding the prognosis of the various stages of pre-B-ALL and T- ALL.
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- 2.Zintl F, Malke H, Plenert W (1985) Clinical experiences with a modified BFM protocol in childhood acute lymphoblastic leukemia. In: Neth R, Gallo RC, Greaves MF, Janka G (eds) Modern trends in human leukemia, vol VI. Springer, Berlin Heidelberg New York, pp 84–89Google Scholar
- 3.Riehm H, Henze G, Langermann HJ (1981) Multizentrische Therapiestudie BFM 81 zur Behandlung der akuten lymphoblastischen Leukämie im Kindes-und Jugendalter. StudienprotokollGoogle Scholar
- 4.Müller-Weihrich S, Henze G, Schwarze EW, Budde M, Riehm H (1986) Childhood Non-Hodgkin’s lymphoma strategies for diagnosis and therapy. In: Riehm H (ed) Malignant neoplasms in childhood and adolescence. Karger, Basel, pp 167–186 (Monogr. Paediatr, vol 18.)Google Scholar