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Correlations of Clinical and Laboratory Data for Prognosis in Childhood Acute Lymphoblastic Leukemia

  • Conference paper
Modern Trends in Human Leukemia VIII

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 32))

  • 93 Accesses

Abstract

The prognostic importance of blast-cell DNA content and chromosomal findings in childhood acute lymphoblastic leukemia (ALL) is known [1–4, 6, 7, 9], but further correlations of hematologic, immunologic, and genetic data are needed for a better understanding of the biology of leukemic cells [5, 10]. Our pilot study is focused on the multivariate analysis of hematologic and genetic data from both a clinical and a laboratory point of view to be used for clinical prognosis in children with newly diagnosed ALL.

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References

  1. Berneman ZN, De Bock R, Van Alsenoy L, Vingerhoets W, Van den Bergh M, Dumon J, Peetermans M (1985) Cytogenetic and DNA-flow cytometric studies of separated blasts. Leuk Res 9 (12): 1463–1466

    Article  PubMed  CAS  Google Scholar 

  2. Heath CW (1973) The epidemiology of leukemia. In: Schottenfield D (ed) Cancer epidemiology and prevention: current concepts

    Google Scholar 

  3. Heim S, Mitelman F (1987) Acute lymphoblastic leukemia. In: Cancer cytogenetics. Liss, New York, pp 141–174

    Google Scholar 

  4. Hiddeman W, Wormann B, Ritter J, Thiel E, Gohde W, Lahme B, Henze G, Schellong G, Riehm H, Buchner T (1986) Frequency and clinical significance of DNA aneuploidy in acute leukemia. Ann NY Acad Sci 458: 227–240

    Article  Google Scholar 

  5. Knudson AG (1988) The genetics of childhood cancer. Bull Cancer (Paris) 75 (1): 135–138

    CAS  Google Scholar 

  6. Look AT, Roberson PK, Wiliams OL, Rivera G, Bowman WP, Pul CHI, Ochs J, Abromowitch M, Kalwinsky D, Dahl GV etal. (1985) Prognostic importance of blast cell DNA content in childhood acute lymphoblastic leukemia. Blood 65 (5): 1079–1086

    PubMed  CAS  Google Scholar 

  7. Michael PM, Garson OM, Ekert H, Tauro G, Rennie GC, Pilkington GR (1988) Prospective study of childhood acute lymphoblastic leukemia: hematologic, immunologic and cytogenetic correlations. Med Pediatr Oncol 16: 153–161

    Article  PubMed  CAS  Google Scholar 

  8. Pui CH, Williams DL, Raimondi SC, Rivera GK, Look AT, Dodge RK, George SL, Behm FG, Crist WM, Murphy SB (1987) Hypodiploidy is associated with a poor prognosis in childhood acute lymphoblastic leukemia. Blood 70 (1): 247–253

    PubMed  CAS  Google Scholar 

  9. Suarez C, Miller DR, Steinherz PG, Melamed MM, Anreeff M (1985) DNA and RNA determination in 111 cases of childhood acute lymphoblastic leukemia (ALL) by flow cytometry: correlation of FAB classification with DNA stemline and proliferation. Br J Haematol 60 (4): 677–686

    Article  PubMed  CAS  Google Scholar 

  10. Ueda T, Aozasa K, Tsujimoto M, Hamada H, Hayashi H, Ono K, Matsumoto K (1988) Multivariate analysis for clinical prognostic factors in 163 patients with soft tissue sarcoma. Cancer 62: 1444–1450

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Genetics, Research Institute of Child Development, V uvalu 84, 15018, Praha 5, Czechoslovakia

    A. Petrakova & K. Venclikova

  2. Faculty of Pediatrics, Charles University, V uvalu 84, 15018, Praha 5, Czechoslovakia

    A. Petrakova & K. Venclikova

  3. 2nd Pediatric Department, University Hospital Motol, V uvalu 84, 15018, Praha 5, Czechoslovakia

    J. Stary & O. Hrodek

  4. Faculty of Pediatrics, Charles University, V uvalu 84, 15018, Praha 5, Czechoslovakia

    J. Stary & O. Hrodek

  5. Department of Clinical Genetics, University Hospital Motol, V uvalu 84, 15018, Praha 5, Czechoslovakia

    P. Goetz

Authors
  1. A. Petrakova
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  2. J. Stary
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  3. O. Hrodek
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  4. P. Goetz
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  5. K. Venclikova
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  6. J. Srajer
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Editor information

Editors and Affiliations

  1. Medizinische Klinik, Abteilung für klinische Chemie, Universitäts-Krankenhaus Eppendorf, Martinistraße 52, 2000, Hamburg 20, Germany

    Rolf Neth

  2. Laboratory of Tumor Cell Biology, National Cancer Institute, 20892, Bethesda, MD, USA

    Robert C. Gallo

  3. Chester Beatty Laboratories, Leukemia Research Fund Centre, Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK

    Melvyn F. Greaves

  4. Abteilung Pädiatrie II, Universitätskinderklinik und Poliklinik Ulm, Prittwitzstr. 43, 7900, Ulm, Germany

    Gerhard Gaedicke

  5. Universität Ulm, Prittwitzstr. 43, 7900, Ulm, Germany

    Gerhard Gaedicke

  6. Labor für Hautimmunologie, Bioverträglichkeit-Immunologie, Paul-Gerson-Unna-Forschungszentrum, Beiersdorf-AG, Unnastr. 48, 2000, Hamburg 20, Germany

    Sven Gohla

  7. Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Martinistr. 52, 2000, Hamburg 20, Germany

    Klaus Mannweiler

  8. Abteilung Hämatologie und Onkologie, Kinderklinik und Poliklinik der Westfälischen Wilhelms-Universität, Albert-Schweitzer-Str. 33, 4400, Münster, Germany

    Jörg Ritter

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© 1989 Springer-Verlag Berlin Heidelberg

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Petrakova, A., Stary, J., Hrodek, O., Goetz, P., Venclikova, K., Srajer, J. (1989). Correlations of Clinical and Laboratory Data for Prognosis in Childhood Acute Lymphoblastic Leukemia. In: Neth, R., et al. Modern Trends in Human Leukemia VIII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74621-5_11

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  • DOI: https://doi.org/10.1007/978-3-642-74621-5_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50967-7

  • Online ISBN: 978-3-642-74621-5

  • eBook Packages: Springer Book Archive

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