Abstract
There are several pieces of evidence that asbestos is a carcinogenic substance. Asbestos exposure also affects the immune system, what may be relevant for carcinogenic process. The immunological outcome of exposure depends in part on the genetically dependent responsiveness of the host (Matej et al. 1978). Among environmental factors polycyclic aromatic hydrocarbons (PAH) increases the risk of asbestos-related cancer (Mossman et al. 1983). This effect also depends on the inherited ability of the host to metabolize PAH to ultimate carcinogens (Kouri et al. 1980). Both asbestos and PAH augment their carcinogenic potential, however, this effect is not seen when asbestos-related immunopathology is evaluated (Lange 1980, Wagner 1981). Therefore, study on the interaction between PAH and asbestos fibres should address the question of the effect on the immune system. To make this work possible an appriopriate model has to be employed to provide a susceptible system for the effect of asbestos fibres and/or PAH on the immunity. F1(NZB*C57Bl/6) mouse hybrid was used. Due to the genetic trait inherited from NZB maternal strain, these mice show the immunological type of responsiveness (Theofilopoulos and Dixon 1981) which resmebles the human situation (HLA B8 antigen associated humoral hypereactivity) known to be a risk factor of asbestos-related immunopathology (Matej et al. 1978).
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References
Alfred LJ, Wojdani A, Nieto M, Perez R, Yoshida G (1983) A chemical carcinogen, 3-methylcholanthrene, alters T-cell function and induces T-suppressor cells in a mouse model system. Immunology 50: 207–213
Anderson DJ, Watson ALM, Yunis E J (1985) Environmental and genetic factors that influence immunity and longevity in mice. In: Woodhead AD, Blackett AD, Hollaender A (eds) Molecular biology of aging, Plenum Press, New York and London, p 231
Davidson A, Shefner R, Diamond B (1987) Studies on the role of somatic mutation in the generation anti-DNA antibodies. In: Dukor P, Hanson LA, Kallos P, Shakib F, Trnka Z, Waksman BH (eds) Monographs in allergy, S.Karger, Basel, p 31
Dzugaj A, Szyba K, Lange A (1985) Adsorption of 3-methylcholanthrene onto chrysotile fibres enhances aryl hydrocarbon hydroxylase inducement in mice. In: Beck EG, Bignon J (eds) In vitro effects of mineral dusts, NATO ASI Series, Vol.G3, Springer-Verlag Berlin Heidelberg, p 467
Harris G, Lawley PD, Asbery LJ, Chandler PM, Jones MG (1983) Autoimmune haemolytic disease in mice after exposure to a methylating carcinogen. Immunology 49: 439–449
Kouri RE, Schechtman LM, Nebert DW (1980) Metabolism of chemical carcinogens. In: Kouri RE (ed) Genetic differences in chemical carcinogenesis, CRC Press, Boca Raton, p 21
Lange A (1980) An epidemiological survey of immunological abnormalities in asbestos workers. II. Serum immunoglobulin levels. Environ Res 22: 176–183
Luster MI, Blank J (1987) Molecular and cellular basis of chemically induced immunotoxicity. Ann Rev Pharmacol Toxicol 27: 23–49
Lyte M, Bick PH (1986) Modulation of interleukin-1 production by macrophages following benzo(a)pyrene exposure. Int J Immunopharmac 8: 377–381
Lyte M, Blanton RH, Myers MJ, Bick PH (1987) Effect of in vivo administration of the carcinogen benzo(a)pyrene on interleukin-1 and interleukin-3 production. Int J Immunopharmac 9: 307–312
Matej H, Lange A, Garncarek D, Smolik R, Roszak E (1978) HLA and antinuclear antibody incidence in asbestos workers. Arch Immunol Ther Exp 26: 201–206
Mossman B, Light W (1983) Asbestos: mechanism of toxicity and carcinogenicity in the respiratory tract. Ann Rev Pharmacol Toxicol 23: 595–615
Myers MJ, Schook LB, Bick PH (1987) Mechanisms of benzo(a)pyrene-induced modulation of antigen presentation. J Pharm Exp Ther 242: 339–404
Pernis B, Vigliani EC (1982) The role of macrophages and immunocytes in the pathogenesis of pulmonary diseases due to mineral dust. Am J Ind Med 3: 133–137
Roitt IM, Doniach D (1969) WHO Mannual on autoimmune serology, WHO,Geneva.
Theofilopoulos AN, Dixon FJ (1981) Etiopathogenesis of murine SLE. Immunological Rev 55: 179–216
Theofilopoulos AN, Prud’homme GJ, Dixon FJ (1985) Autoimmune aspects of systemic lupus erythematosus. In: Cruse JM, Lewis RE (eds) Autoimmunity: basic concepts; systemic and selected organ-specific diseases. Karger Basel, p 190
Wagner MMF, Campbell MJ, Edwards RE (1979) Sequential immunological studies on an asbestos-exposed population. I. Factors affecting peripheral blood leucocytes and T lymphocytes. Clin Exp Immunol 38: 323–331
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© 1989 Springer-Verlag Berlin Heidelberg
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Lange, A., Pietrzyca, B., Moniewska, A., Rabczynski, J. (1989). Long-Term Effect of 3Methylcholanthrene-Coated Asbestos Fibres on the Immune Status of F1(NZB*C57B1/6) Mice. In: Mossman, B.T., Bégin, R.O. (eds) Effects of Mineral Dusts on Cells. NATO ASI Series, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74203-3_17
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DOI: https://doi.org/10.1007/978-3-642-74203-3_17
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