Abstract
To study the functional properties of HLA molecules, genes encoding these proteins have been isolated and used to transfect mouse cells. We have isolated the genes encoding the HLA-B27k and -B27w proteins (Seemann et al. 1986). A number of diseases are associated with certain HLA alleles. Of these associations, the one linking the HLA-B27 alleles with ankylosing spondylitis is the most pronounced. Several models have been presented over the past few years to explain this fact. However, the lack of a proper model system to study this HLA disease association has restricted the experimental basis for these theories. Transgenic mice may provide us with a better defined model system to study the immunobiology of HLA-B27 and — together with biochemical analysis of the HLA-B27 gene product — may give us better insight into HLA disease association.
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© 1988 Springer-Verlag Berlin Heidelberg
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Baas, E.J., Derhaag, P.J.F.M., Ploegh, H.L. (1988). Biochemistry of HLA-B27 in Transfected Cells and Transgenic Mice. In: Ivanyi, P. (eds) MHC + X. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74026-8_20
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DOI: https://doi.org/10.1007/978-3-642-74026-8_20
Publisher Name: Springer, Berlin, Heidelberg
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