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MHC + X

Complex Formation and Antibody Induction

  • Pavol Ivanyi
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XXII
  2. P. Ivanyi, R. Černý-Provaznik, P. C. van Mourik
    Pages 7-13
  3. M. M. Tongio, Y. Mitsuishi, A. Urlacher, S. Mayer
    Pages 18-22
  4. Franco Ameglio, Rosa Sorrentino, Antonina Dolei, Nobuyuki Tanigaki, Roberto Tosi
    Pages 23-29
  5. A. van Leeuwen, F. P. M. J. van Bree, C. J. Beukelman, J. J. van Rood
    Pages 30-33
  6. E. Goulmy, A. van Leeuwen, J. J. van Rood
    Pages 34-37
  7. Antonio Garrido, Ignacio Algarra, Concepción Delgado, Abelardo Caballero, Matias Pérez, Federico Garrido
    Pages 93-99
  8. Matthias Cramer, Rudolf Mierau, Wolfgang Kuon, Elisabeth Weiss, Peter J. Robinson
    Pages 107-113
  9. Peter Parham
    Pages 114-118
  10. Pavol Ivanyi, Femia Kievits
    Pages 119-127
  11. Erik J. Baas, Paul J. F. M. Derhaag, Hidde L. Ploegh
    Pages 128-133
  12. Margriet Oudshoorn-Snoek, Surish Raghoebier, Lorraine Flaherty, Peter Demant
    Pages 134-137
  13. Jane E. Grundy, Jane A. Mckeating, Paul D. Griffiths
    Pages 171-177
  14. Brian H. Barber, Margaret H. Smith, Hamish Allen, David B. Williams
    Pages 193-205
  15. Elizabeth S. Song, Richard Linsk, Robert S. Goodenow
    Pages 206-213
  16. F. H. J. Claas, W. Verduyn, M. Mommaas-Kienhuis, W. M. A. Verhoeven, J. M. van Ree, J. J. van Rood
    Pages 214-217
  17. M. Laurie Phillips, Margaret L. Moule, Cecil C. Yip
    Pages 218-225
  18. P. B. Singh, R. E. Brown, B. J. Roser
    Pages 226-240
  19. Back Matter
    Pages 245-247

About these proceedings

Introduction

After the discovery of the function of MHC molecules, namely to provide the context for T cell recognition of foreign antigens, in 1974 Zinkernagel and Doherty made the first drawing of MHC+X (Fig. 1 from Zinkernagel and Doherty, Nature, 251: 547, 1974). Over the next 18 years a very large number of similar drawings ensued, some of real artistic beauty. One side of the problem, the nature of the T cell receptor, was unraveled; however, we still do not know exactly what kind of a structure the T cell receptor recognizes, al­ though in 1987 we learned so much about the structure of MHC molecules and antigen presentation. In schematic presentations no one is now placing the foreign antigen beside the MHC molecule, but rather on top of it, as pointed out by J. L. Strominger at the MHC + X meeting in Paris. The complex of MHC and antigen is named MHC + X, but the precise meaning of this formula remains a "problem perplex", as illustrated in these proceedings by Peter Par­ ham. When planning the Ommen/Amsterdam meeting at the begin­ ning of 1987, its major aim was seen as to discuss the question of whether MHC + X can induce antibodies and, consequently, their specificity. In other terms, whether - in analogy to antigen specific MHC restricted T cells - MHC restricted antibodies also exist.

Keywords

antibody antigen histocompatibility

Editors and affiliations

  • Pavol Ivanyi
    • 1
  1. 1.Central Laboratory of the Netherlands, Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical ImmunologyUniversity of AmsterdamAmsterdamThe Netherlands

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-74026-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 1988
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-74028-2
  • Online ISBN 978-3-642-74026-8
  • Buy this book on publisher's site
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