Abstract
T cell recognition of foreign antigen is MHC restricted. This restriction holds for helper as well as cytolytic T cells. A major part of the problem of MHC restriction is connected with the structure and binding site specificity of the T cell receptor (TcR). The serendipity of discovery and changing views about TcR specificity have been reviewed by various authors. The most typical situation can still be characterized by the original description of the MHC restriction phenomenon by Zinkernagel and Doherty (1974, 1979). They found that antiviral cytotoxic T-lymphocytes (CTLs) recognize antigen only on target cells together with self-MHC molecules. The phenomenon has been amply confirmed, although various observations have extended the horizon: (a) viral-specific CTLs frequently recognize MHC alloantigens without virus, (b) determinants shared by various MHC molecules can restrict antigen recognition (cross-reactions among MHC molecules), (c) determinants shared by various foreign antigens can be recognized by the same CTL (cross-reactions among foreign antigens), (d) allo-(MHC)-restricted clones are induced when responder cells are stimulated with alloantigen and virus, and (e) exceptionally, autoreactive T cell clones have been described that have recognized not only allogeneic but also syngeneic cells without antigen.
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References
Allen PM, Matsueda GR, Evans RJ, Dunbar JB, Marshall GR, Unanue ER (1987) Identification of the T cell and la contact residues of a T cell antigenic epitope. Nature 327: 713–715
Bjorkman PJ, Saper MA. Samraoui B, Bennett WS, Strominger JL, Wiley DC (1987) Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329: 506–512
Froscher BG, Klinman NR (1986) Immunization with SV40-transformed cells yields mainly MHC-restricted monoclonal antibodies. J Exp Med 164: 196–210
Ivanyi P, van Mourik P, Breuning MH, Melief CJM (1980) Anti-H-2 antibodies induced by syngeneic immunization. Immunogenetics 10: 319–332
Ivanyi P, van Mourik P, Breuning MH, Kruisbeek AM, Kröse CJM (1982) Natural anti-H-2 antibodies in sera of aged mice. Immunogenetics 15: 95–102
Kievits F, Ivanyi P (1987) Monomorphic anti-HLA monoclonal antibody (W6/32) recognizes polymorphic H-2 heavy-chain determinants exposed by association with bovine or human but not murine beta-2-microglobulin. Hum Immunol 20: 115–126
Kievits F, Rocca A, Opolski A, Limpens J, Leupers T, Kloosterman T, Boerenkamp WP, Pla M, Ivanyi P (1987) Induction of H-2 specific antibodies by injections of syngeneic Sendai virus-coated cells. Eur J Immunol 17: 27–35
Kievits F, Opolski A, Boerenkamp WJ, Pla M, Ivanyi P (1988a) Monoclonal H-2 class I specific antibodies isolated after immunization of C57B1/6 mice with syngeneic Sendai virus-coated cells. In: David C (ed) H-2 antigens: genes, molecules, function. Plenum, New York, pp 669–680
Kievits F, Boerenkamp WJ, Ivanyi P (1988b) H-2 dependent binding of xenogeneic beta-2-microglobulin from culture media. J Immunol 140: 4253–4255
Kievits F, Boerenkamp W, Ivanyi P (1988c) Immunization with syngeneic sendaivirus-infected cells induce no MHC-restricted antibodies but antibodies specific for H-2 class-l determinants. Immunogenetics, in press
Levy RG, Dower SK, Shearer GM, Segal DM (1984) Trinitrophenol modification of H-2k and H-2b spleen cells results in serological detection of Kk-like determinants. J Exp Med 159: 4164–1472
Mickova M (1975) The effect of orchiectomy on the manifestation of Thy-1b (theta-C3H) antigen in H-2 congeneic mouse strains. Folia Biol (Praha) 20: 343–345
Mickova M, Ivanyi P (1973) Genetic differences in the manifestation of theta-C3H-antigen. Association with the H-2 system. Transplant Proc 5: 1421–1425
Ohno S, Stapleton DW (1981) Associative recognition of testis-organizing H-Y antigen and immunological confusion. In: Jagielle G, Vogel A (eds) Bioregulators of reproduction. Academic, New York, pp 25–42
Opolski A, Kievits F, Ivanyi P (1986) Polymorphic and autoreactive H-2 specific monoclonal antibodies isolated after injections of syngeneic Sendai virus-coated lymphocytes. Immunogentics 24: 402–408
Pestalozzi B, Stitz L, Zinkernagel RM (1987) Monoclonal antibodies against viral determinants are not restricted to the K/D end of the MHC. J Exp Med 166: 295–299
Scheid M, Boyse EA, Carswell EA, Old LJ (1972) Serologically demonstrable alloantigens of mouse epidermal cells. J Exp Med 135: 938–955
Schmidt W (1987) H-2 specific antibodies induced by injection of syngeneic leukemia cells. Immunogenetics 25: 215–221
Sette A, Buus S, Colon S, Smith JA, Miles C, Grey HM (1987) Structural characteristics of an antigen required for its interaction with la and recognition by T cells. Nature 328: 395–399
Sherman LA, Vitiello A, Klinman NR (1983) T-cell and B-cell responses to viral antigens at the clonal level. Annu Rev Immunol 1: 63–86
Tamminen WL, Wraith D, Barber BH (1987) Searching for MHC restricted antiviral antibodies: antibodies recognizing the nucleoprotein of influenza virus dominate the serological response of C57B1/6 mice to syngeneic influenza-infected cells. Eur J Immunol 17: 999–1006
Van Leeuwen AE, Goulmy A, van Rood JJ (1979) Major histocompatibility complex restricted antibody reactivity mainly, but not exclusively, directed against cells from male donors. J Exp Med 150: 1075–1083
Wylie DE, Klinman NR (1981) The murine B cell repertoire responsive to an influenza infected syngeneic cell line. J Immunol 127: 194–198
Wylie DE, Sherman LA, Klinman NR (1982) Participation of the major histocompatibility complex in antibody recognition of viral antigens expressed on infected cells. J Exp Med 155: 403–414
Zinkernagel RM, Doherty PC (1974) Restriction of in vitro T cell mediated cytotoxicity in lymphocytic chorionmeningitis within a syngeneic or semi-allogeneic system. Nature 248: 701
Zinkernagel RM, Doherty PC (1979) MHC restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T cell restriction specificity. Adv Immunol 27: 51–177
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Ivanyi, P., Kievits, F. (1988). MHC-Restricted Antibodies: Facts and Interpretation. In: Ivanyi, P. (eds) MHC + X. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74026-8_19
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DOI: https://doi.org/10.1007/978-3-642-74026-8_19
Publisher Name: Springer, Berlin, Heidelberg
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