Abstract
Class I antigens encoded by the major histocompatibility complex (MHC) are notable for their high level of interspecies homology. The monoclonal antibody COB6-3 highlights some aspects of this feature. The antibody’s production, characterization, and specificity are reviewed and summarized in this article.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Arnold B, Horstmann U, Kuon W, Burgert HG, Hämmerling GJ, Kvist S (1985) Alloreactive cytolytic T-cell clones preferentially recognize conformational determinants on histocompatibility antigens: analysis with genetically engineered antigens. Proc Natl Acad Sci USA 82: 7030–7034
Barnstable CJ, Bodmer WF, Brown G, Galfre G, Milstein C, Williams AF, Ziegler A (1978) Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens. New tools for genetic analysis. Cell 14: 9–20
Bernabeu C, van de Rijn M, Lerch PG, Terhorst CP (1984) β 2-Microglobulin from serum associates with MHC class I antigens on the surface of cultured cells. Nature 308: 642–645
Grosveld FG, Lund T, Murray EJ, Mellor AI, Dahl HHM, Flavell RA (1982) The construction of cosmid libraries which can be used to transform eukaryotic cells. Nucleic Acids Res 10: 6715–6732
Hämmerling GJ, Rüsch E, Tada N, Kimura S, Hämmerling U (1982) Localization of allodeterminants on H-2Kb antigens determined with monoclonal antibodies and H-2 mutant mice. Proc Natl Acad Sci USA 79: 4737–4741
Ivanyi D, van de Meugheuvel W (1984) A monomorphic HLA-specific monoclonal antibody, W6/32, reacts with the H-2Db molecule of normal mouse lymphocytes. Immunogenetics 20: 699–703
Ivanyi P, van Mourik P, Breuning M, Melief CJM (1980) Anti-H-2 antibodies induced by syngeneic immunization. Immunogenetics 10: 319–322
Kahn-Perles B, Boyer C, Arnold B, Sanderson AR, Ferrier P, Lemonnier FA (1987) Acquisition of HLA class I W6/32 defined antigenic determinant by heavy chains from different species following association with bovine β 2-microglobulin. J Immunol 138: 2190–2196
Lemke H, Hämmerling GJ, Hämmerling U (1979) Fine specificity analysis with monoclonal antibodies of antigens controlled by the major histocompatibility complex and by the Qa/ TL region in mice. Immunol Rev 47: 175–206
Maziarz RT, Fraser J, Strominger JL, Burakoff SJ (1986) The human HLA-specific monoclonal antibody W6/32 recognizes a discontinuous epitope within the α2 domain of murine H-2Db. Immunogenetics 24: 206–208
Mierau R, Cramer M (1984) Serological and immunochemical analysis of H-2 class I molecules encoded by the Db region. Immunogenetics 20: 341–345
Mierau R, Robinson PJ, Sanderson AR, Genth E, Cramer M (1987) Antigenic determinants shared between HLA-A, -B, -C antigens and H-2 class I molecules modified by bovine beta-2 microglobulin. Immunogenetics 26: 351–355
Parham P, Sehgal PK, Brodsky FM (1979) Anti-HLA-A, B, C monoclonal antibodies with no alloantigenic specificity in humans define polymorphisms in other primate species. Nature 279: 639–641
Schmidt W, Festenstein H, Ward PJ, Sanderson AR (1981) Interspecies exchange of β 2-microglobulin and associated MHC and differentiation antigens. Immunogenetics 13: 483–491
Schmidt W, Fergula J, Festenstein H, Weiss E (1985) Identification of murine H-2Db histocompatibility antigens in cells transfected with cloned H-2 genes. Mol Immunol 22: 1151–1158
Smilek DE, Boyd HE, Wilson DB, Zmijewski CM, Fitch FW, McKearn TJ (1980) Monoclonal rat anti-major histocompatibility complex antibodies display specificity for rat, mouse, and human target cells. J Exp Med 151: 1139–1150
Weiss EH, Golden L, Fahrner K, Mellor AL, Devlin JJ, Bullman H, Tiddens H, Bud H, Flavell RA (1984) Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse. Nature 310: 650–655
Wigler M, Pellicerk A, Silverstein S, Axel R, Urlauss G, Chasin L (1979) DNA-mediated transfer of the adenine phosphoribosyltransferase. Proc Natl Acad Sci USA 76: 1373–1376
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Cramer, M., Mierau, R., Kuon, W., Weiss, E., Robinson, P.J. (1988). A Monoclonal Antibody Induced by H-2 Syngeneic ConA Blasts: Its Reactivity Pattern with Mouse and Human MHC Class I Antigens. In: Ivanyi, P. (eds) MHC + X. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74026-8_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-74026-8_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-74028-2
Online ISBN: 978-3-642-74026-8
eBook Packages: Springer Book Archive