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Homology of Calcium-Modulated Proteins: Their Evolutionary and Functional Relationships

  • Conference paper
The Calcium Channel: Structure, Function and Implications

Part of the book series: Bayer AG Centenary Symposium ((BAYER))

Abstract

In 1972 Kretsinger published a “Gene Triplication Deduced from the Tertiary Structure” of parvalbumin. He then proposed (1975) that “ Calcium Modulated Proteins Contain EF-Hands”. Calcium-modulated proteins, as a distinct superfamily of all the proteins that bind calcium, are defined by two characteristics. They are found within the cytosol or on a membrane facing the cytosol. They bind calcium with a dissociation constant about 10-6 M under cytosolic conditions, i. e., about 10-3 M free Mg2+ ion. They are inferred to be involved in transmitting the information inherent in calcium’s functioning as a cytosolic messenger.

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Author information

Authors and Affiliations

  1. Department of Biology, University of Virginia, Charlottesville, VA, 22901, USA

    R. H. Kretsinger & N. D. Moncrief

  2. Center for Molecular Biology, Wayne State University, Detroit, MI, 48201, USA

    N. D. Moncrief

  3. Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, 48201, USA

    N. D. Moncrief, M. Goodman & J. Czelusniak

Authors
  1. R. H. Kretsinger
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  2. N. D. Moncrief
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  3. M. Goodman
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  4. J. Czelusniak
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Editor information

Editors and Affiliations

  1. Department of Physiology, University of Pennsylvania, Philadelphia, PA, 19104-6085, USA

    Martin Morad (Professor of Physiology and Medicine) (Professor of Physiology and Medicine)

  2. Department of Medicine, Austin Hospital, University of Melbourne, Heidelberg, 3084, Victoria, Australia

    Winifred G. Nayler (Principal Research Investigator) (Principal Research Investigator)

  3. Bayer AG, Institute of Pharmacology, Aprather Weg 18a, D-5600, Wuppertal 1, Germany

    Stanislav Kazda (Associate Professor of Pharmacology and Toxicology) & Matthias Schramm (Associate Professor of Physiology) (Associate Professor of Pharmacology and Toxicology) &  (Associate Professor of Physiology)

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© 1988 Springer-Verlag Berlin Heidelberg

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Kretsinger, R.H., Moncrief, N.D., Goodman, M., Czelusniak, J. (1988). Homology of Calcium-Modulated Proteins: Their Evolutionary and Functional Relationships. In: Morad, M., Nayler, W.G., Kazda, S., Schramm, M. (eds) The Calcium Channel: Structure, Function and Implications. Bayer AG Centenary Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73914-9_3

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  • DOI: https://doi.org/10.1007/978-3-642-73914-9_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50061-2

  • Online ISBN: 978-3-642-73914-9

  • eBook Packages: Springer Book Archive

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