Metabolic Activation and Cytotoxicity of Airborne Particulate Matter

  • J. J. van Houdt
Conference paper

Abstract

Mutagenic activity of airborne particulate matter is mainly located on the smallest particles.

Keywords

Combustion Toxicity DMSO Ozone Hydrocarbon 

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References

  1. (1).
    Ames, B.N., J McCan and E. Yamasaki (1975) Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity test. Mutation Res. 31, 347–364.PubMedGoogle Scholar
  2. (2).
    Centrell, E.T., G.A. Warr., D.L. Busbee, and R.R. Martin (1973) Induction of aryl hydrocarbon hydroxylase in human pulmonary alveolar macrophages by cigarette smoking. J. Air Invest. 52, 1884–1991.Google Scholar
  3. (3).
    Gardner, D.E. (1984) Alterations in macrophage functions by environmental chemicals. Environ. Health Persp. 55, 343–358.CrossRefGoogle Scholar
  4. (4).
    Harris, C.C., I.C. Hsu, G.D. Stoner, B.T. Trump and J.K. Selkirk (1978) Human pulmonary macrophages metabolise benzo(a)pyrene to proximate and ultimate mutagens. Nature 272, 633–634.PubMedCrossRefGoogle Scholar
  5. (5).
    Houdt van J.J., W.M.F. Jongen, G.M. Aling and J.S.M. Boley (1984) Mutagenic activity of airborne particles inside and outside homes. Environ. Mutagen. 6, 861–869.PubMedCrossRefGoogle Scholar
  6. (6).
    Houdt van J.J., C.M.J. Daenen, J.S.M. Boley and G.M. Alink (1986) Contribution of wood stoves and open fire places to mutagenic activity of airborne particulate matter inside homes. Mutat. Res. 171, 91–98.PubMedCrossRefGoogle Scholar
  7. (7).
    Houdt van J.J., G.M. Alink and J.S.M. Boley (1987) Mutagenicity of airborne particles related to meteorological and air pollution parameters. The Sci. Total Environ. 61, 23–36.CrossRefGoogle Scholar
  8. (8).
    Mason, R.J., M.C. Williams, R.D. Greenleaf and J.A. Clements (1977) Isolation and properties of Type II alveolar cells from rat lung. Am. Rev. Resp. Dis. 115, 1015–1026.PubMedGoogle Scholar
  9. (9).
    Rietjens I.M.C.M.; L. v Bree, M. Marra, M.C.M. Poelen, P.J.A. Rombout and G.M. Alink (1985) Gluthation pathway enzyme activities and the ozone sensitivity of lung cell populations derived from ozone exposed rats. Toxicology 37, 205–214PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • J. J. van Houdt
    • 1
  1. 1.Department of ToxicologyAgricultural UniversityWageningenThe Netherlands

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