Abstract
Benzene, although restricted in many countries for direct consumer utilization is still an important component in manufacturing and energy sources which finds its way into the environment. The interaction of this ubiquitous and mutagenic pollutant and common putative oncogenic viruses is of obvious concern. Host cell lysosome activity is known to modulate herpesvirus activity1 and benzene which enhances cell transfor mation by HSV-2 virus2 is known to destabilize lysosome integrity3,4. Hence, we decided to compare the effects of benzene and two lysosome sta bilizers, hydrocortisone and chloroquine on lysosome membrane permeability during infection by two types of Herpes simplex virus HSV-1, type one and HSV-2, type two.
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© 1988 Springer-Verlag Berlin Heidelberg
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Orsi, E.V., Joshi, S., Bavlsik, M., Petersheim, M., Peng, Y. (1988). Effects of Benzene and Other Lysosomotropic Agents on Ultraviolet Light Induced Photolysis of Lysosomes in Herpesvirus Infected Cells. In: Seemayer, N.H., Hadnagy, W. (eds) Environmental Hygiene. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73766-4_10
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DOI: https://doi.org/10.1007/978-3-642-73766-4_10
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