Abstract
Nephrocalcinosis, the sedimentation of calciferous deposits in renal tissue, has been described by several authors. There is contradictory evidence on the localization of concrements found, indicating that the pathogenesis is to a large extent unknown and that renal lesions present themselves in several ways. Probably these lesions are partly dystrophic calcifications caused by cell damage, as they are known to occur in other organs [6]; for example myocardnecrosis leads to calcification of heart-muscle cells. Experimental investigations demonstrated that these calcifications can be reduced by calcium antagonists [7, 10, 17]. Similar starting points result from experimental feeding of animals in which a nephrocalcinosis was induced. The aim of these investigations was to establish animal models to examine and explain alterations in the parameters which cause nephrocalcinosis.
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Nelde, HJ., Bichler, KH., Strohmaier, W.L., Kriz, W. (1988). Nephrocalcinosis in the Kidney of the Rat on Atherogenic Diet and the Effect of Calcium Antagonists (Nifedipine). In: Bichler, KH., Strohmaier, W.L. (eds) Nephrocalcinosis Calcium Antagonists and Kidney. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72857-0_8
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DOI: https://doi.org/10.1007/978-3-642-72857-0_8
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