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Abstract

About 60% of filtered calcium is reabsorbed within the proximal convoluted tubule (Fig. 1). In the beginning of the proximal tubule (first millimeter) net calcium reabsorption lags behind net fluid reabsorption and tubular fluid calcium concentration (TF) is found to exceed that in ultrafiltrate (UF) by 10–20%. Accordingly, the ratio TF/UF approaches 1.1–1.2. In later portions of the proximal tubule calcium reabsorption parallels fluid reabsorption and TF/UF remains constant [1, 14, 17–19, 32, 46, 50, 53].

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References

  1. Agus ZS, Chiu PJS, Goldberg M (1977) Regulation of urinary calcium excretion in the rat. Am J Physiol 232: F545–F549

    PubMed  CAS  Google Scholar 

  2. Antoniou LD. Eisner GM, Slotkoff LM, Lilienfield LS (1969) Relationship between sodium and calcium transport in the kidney. J Lab Clin Med 74: 410–420

    PubMed  CAS  Google Scholar 

  3. Beck LH, Goldberg M (1973) Effects of acetazolamide and phosphate. Am J Physiol 224: 1136–1142

    PubMed  CAS  Google Scholar 

  4. Berndt TJ, Knox FG (1980) Effects of parathyroid hormone and calcitonin on electrolyte excretion in the rabbit. Kidney Int 17: 473–478

    Article  PubMed  CAS  Google Scholar 

  5. Boron WF, Boulpaep EL (1983) Intracellular pH regulation in the renal proximal tubule of the salamander. J Gen Physiol 81: 29–94

    Article  PubMed  CAS  Google Scholar 

  6. Bourdeau JE, Burg MB (1979) Voltage dependence of calcium transport in the thick ascending limb of Henle’s loop. Am J Physiol 236: F357–F364

    PubMed  CAS  Google Scholar 

  7. Burckhardt BC, Sato K, Frömter E (1984) Electrophysiological analysis of bicarbonate permeation across the peritubular cell membrane of rat kidney proximal tubule. Pflüaers Arch 401: 34–51

    Article  CAS  Google Scholar 

  8. Burnatowska MA, Harris CA, Sutton RAL, Dirks JH (1977) Effects of PTH and cAMP on renal handling of calcium, magnesium, and phosphate in the hamster. Am J Physiol 233: F514–F518

    PubMed  CAS  Google Scholar 

  9. Carney SL, Wong NLM, Quamme GA, Dirks JH (1980) Effect of magnesium deficiency on renal magnesium and calcium transport in the rat. J Clin Invest 65: 180–188

    Article  PubMed  CAS  Google Scholar 

  10. Costanzo LS, Weiner IM (1974) On the hypocalciuric action of chlorothiazide. J Clin Invest 54: 628–637

    Article  PubMed  CAS  Google Scholar 

  11. Costanzo LS, Weiner IM (1976) Relationship between clearances of Ca and Na: Effect of distal diuretics and PTH. Am J Physiol 230: 67–73

    PubMed  CAS  Google Scholar 

  12. Costanzo LS, Windhager EE (1978) Calcium and sodium transport by the distal convoluted tubule of the rat. Am J Physiol 235: F492–F506

    PubMed  CAS  Google Scholar 

  13. De Rouffignac C, Morel F, Moss N, Roinel N (1973) Micropuncture study of water and electrolyte movements along the loop of Henle in psammomys with special reference to magnesium. calcium, and phosphorus. Pflügers Arch 344: 309–326

    Article  PubMed  Google Scholar 

  14. Di Stefano A. Wittner M, Gebbier B, Greger R (1984) Increased Ca++ or Mg++ reduces the Na+ conductance of the paracellular pathway in isolated perfused cortical thick ascending limbs of Henle loops (cTAL) of rabbit kidney. Pflügers Arch 400:R21(84)

    Google Scholar 

  15. Duarte CG. Bland JH (1965) Calcium, phosphorus, and uric acid clearances after intravenous administration of chlorothiazide. Metabolism 14: 211–219

    Article  PubMed  CAS  Google Scholar 

  16. Duarte CG, Watson JF (1967) Calcium reabsorption in proximal tubule of the dos nephron. Am J Physiol 212: 1355–1360

    PubMed  CAS  Google Scholar 

  17. Edwards BR, Baer PG, Sutton RAL, Dirks JH (1973) Micropuncture study of diuretic effects on sodium and calcium reabsorption in the dog nephron. J Clin Invest 52: 2418–2427

    Article  PubMed  CAS  Google Scholar 

  18. Frick A, Rumrich G, Ullrich KJ, Lassiter WE (1965) Microperfusion study of calcium trans-port in the proximal tubule of the rat kidney. Pflügers Arch 286: 109–117

    Article  CAS  Google Scholar 

  19. Frömter E (1974) Electrophysiology and isotonic fluid absorption of proximal tubules of mammalian kidney. In: Guyton AC, Thurau K (eds) Kidney and urinary tract physiology, vol 6. Buttenvorths Univ Park Press, London, pp 1–39

    Google Scholar 

  20. Frömter E (1979) Solute transport across epithelia: What can we learn from micropuncture studies on kidney tubules? J Physiol 288: 1–31

    PubMed  Google Scholar 

  21. Frömter E, Müller CW, Knauf H (1968) Fixe negative Wandladungen im proximalen Konvolut der Rattenniere und ihre Beeinflussung durch Calciumionen. In: Watschinger B (ed) Aktuelle Probleme des Elektrolyt- und Wasserhaushalts, Nierenbiopsie. Verlag d Wiener Med Akad, 61–64

    Google Scholar 

  22. Frömter E, Rumrich G, Ullrich KJ (1973) Phenomenologic description of Na+, CL- and HCO3- absorption from proximal tubules in the rat kidney. Pflügers Arch 343: 189–220

    Article  PubMed  Google Scholar 

  23. Gmaj P, Murer H, Kinne R (1979) Calcium ion transport across plasma membranes isolated from rat kidney cortex. Biochem J 178: 549–557

    PubMed  CAS  Google Scholar 

  24. Greger R (1985) Ion transport mechanisms in thick ascending limb of Henle’s loop of mammalian nephron. Physiol Rev 65 (3): 760–797

    PubMed  CAS  Google Scholar 

  25. Greger R, Lang F, Oberleithner H (1978) Distal site of calcium reabsorption in the rat nephron. Pflügers Arch 374: 153–157

    Article  PubMed  CAS  Google Scholar 

  26. Greger R, Lang F, Oberleithner H, Sporer H (1978) Efflux of 45Calcium from proximal and distal nephron segments - effects of a diuretic (piretanide) and PTH. Pflügers Arch 377: R49

    Google Scholar 

  27. Greger R, Schlatter E, Lang F (1983) Evidence for electroneutral sodium chloride cotransport in the cortical thick ascending limb of Henle’s loop of rabbit kidney. Pflügers Arch 396: 308–314

    Article  PubMed  CAS  Google Scholar 

  28. Handler JS, Perkins FM, Johnson JP (1980) Studies of renal function using cell culture tech-niques. Am J Physiol 238: F1–F9

    PubMed  CAS  Google Scholar 

  29. Handler JS (1983) Use of cultured epithelia to study transport and its regulation. J Exp Biol 106: 55–69

    PubMed  CAS  Google Scholar 

  30. Harris CA, Baer PG, Chirito E, Dirks JH (1974) Composition of mammalian glomerular filtrate. Am J Physiol 227: 972–976

    PubMed  CAS  Google Scholar 

  31. Hierholzer K (1985) Sodium Reabsorption in the Distal Tubular System. In: Seldin DW, Giebisch G (eds) The kidney: physiology and pathophysiology, vol 2. Raven Press. New York, pp 1063–1096

    Google Scholar 

  32. Imai M (1978) Calcium transport across the rabbit thick ascending limb of Henle’s loop perfused in vitro. Pflügers Arch 374: 255–263

    Article  PubMed  CAS  Google Scholar 

  33. Jamison RL, Frey NR, Lacy FB (1974) Calcium reabsorption in the thin loop of Henle. Am J Physiol 227: 745–751

    PubMed  CAS  Google Scholar 

  34. Kinne-Saffran E. Kinne R (1974) Localization of a calcium-stimulated ATPase in the basallateral plasma membranes of the proximal tubule of the rat kidney cortex. J Membr Biol 17: 263–274

    Article  PubMed  CAS  Google Scholar 

  35. Kinne R, Keljo D, Gmaj P, Murer H (1977) The energy source of glucose and calcium transport in the renal proximal tubule. Excerpta Med Int Congr Ser No. 422, July, 1977

    Google Scholar 

  36. Kleeman CR, Bernstein D, Rockney R, Dowling JT, Maxwell MH (1961) Studies on the renal clearance of diffusible calcium and the role of the parathyroid glands in its regulation. Yale J Biol Med 34: 1–30

    PubMed  CAS  Google Scholar 

  37. Koeppen BM, Biagi BA, Giebisch G (1983) Intracellular microelectrode characterization of the rabbit cortical duct. Am J Physiol 244: F35–F47

    PubMed  CAS  Google Scholar 

  38. Koeppen BM, Giebisch G, Malnic G (1985) Mechanism and regulation of renal tubular acidification. In: Seldin DW, Giebisch G (eds) The kidney: physiology and pathophysiology, vol 2. Raven Press, New York, pp 1491–1525

    Google Scholar 

  39. Lang F, Defregger M, Paulmichl M (1986) Apparent chloride conductance of subconfluent Madin Darby canine kidney cells. Pflügers Arch 407: 158–162

    Article  PubMed  CAS  Google Scholar 

  40. Lang F, Joost J, Oberleithner H, Schwarz S, Pastner D (1981) Hyperglycemic calciuria. In: Calcium and phosphate transport across biomembranes. Academic Press, New York, pp 209–212

    Google Scholar 

  41. Lang F, Messner G, Rehwald W (1986) Electrophysiology of sodium-coupled transport in proximal renal tubules. Am J Physiol 250: F953–F962

    PubMed  CAS  Google Scholar 

  42. Lang F, Messner G, Wang W, Oberleithner H (1983) Interaction of intracellular electrolytes and tubular transport. Klin Wochenschr 61: 1029–1037

    Article  PubMed  CAS  Google Scholar 

  43. Lang F, Paulmichl M, Defregger M, Gstraunthaler G, Pfaller W, Deetjen P (1987) Transport systems in cultured epithelial kidney cells (MDCK) and their modulation by diuretics and hormones. In: Puschett, Greenberg (eds) Diuretics II. Elsevier Science Publishing, 107–120

    Google Scholar 

  44. Lassiter WE, Gottschalk CW, Mylle M (1963) Micropuncture study of renal tubular reabsorption of calcium in normal rodents. Am J Physiol 204: 771–775

    CAS  Google Scholar 

  45. Lee CO, Taylor A, Windhager EE (1980) Cytosolic calcium ion activity in epithelial cells of Necturus kidney. Nature 287: 859–861

    Article  PubMed  CAS  Google Scholar 

  46. Le Grimellec C, Roinel N, Morel F (1973) Simultaneous Mg, Ca, P, K, Na, and CI analysis in rat tubular fluid. I. During perfusion of either inulin or ferrocyanide. Pflügers Arch 340: 181–195

    Article  PubMed  Google Scholar 

  47. Le Grimellec C, Roinel N, Morel F (1973) Simultaneous Mg, Ca, P, K, Na, and CI analysis in rat tubular fluid. II. During acute Mg plasma loading. Pflügers Arch 340: 197–210

    Article  PubMed  Google Scholar 

  48. Le Grimellec C (1975) Micropuncture study along the proximal convoluted tubule. Electrolyte reabsorption in first convolutions. Pflügers Arch 354: 133–150

    Article  PubMed  Google Scholar 

  49. Massry SG, Ahumada J J, Coburn JW, Kleeman CR (1970) Effect of MgC12 infusion on urinary Ca and Na during reduction in their filtered loads. Am J Physiol 219: 881–885

    PubMed  CAS  Google Scholar 

  50. Morel F, Roinel N, Le Grimellec C (1969) Electron probe analysis of tubular fluid composition. Nephron 6: 350–364

    Article  PubMed  CAS  Google Scholar 

  51. Morel F, Chabardes D, Imbert M (1976) Functional segmentation of the rabbit distal tubule by microdetermination of hormone-dependent adenylate cyclase activity. Kidney Int 9: 264–277

    Article  PubMed  CAS  Google Scholar 

  52. Oberleithner H. Giebisch G, Lang F, Wang W (1982) Cellular mechanism of the furosemide sensitive transport system in the kidney. Klin Wochenschr 60: 1173–1179

    Article  PubMed  CAS  Google Scholar 

  53. Paulmichl M, Gstraunthaler G, Lang F (1985) Electrical properties of Madin-Darby canine kidney cells: effects of extracellular potassium and bicarbonate. Pflügers Arch 405: 102–107

    Article  PubMed  CAS  Google Scholar 

  54. Paulmichl M, Defregger M, Lang F (1986) Effects of epinephrine on electrical properties of Madin-Darby canine kidney cells. Pflügers Arch 406: 367–371

    Article  PubMed  CAS  Google Scholar 

  55. Paulmichl M, Friedrich F, Lang F (1986) Electrical properties of Madin Darby canine kidney cells: effects of extracellular sodium and calcium. Pflügers Arch 407: 258–263

    Article  PubMed  CAS  Google Scholar 

  56. Peacock M, Robertson WG, Nordin BEC (1969) Relation between serum and urinary calcium with particular reference to parathyroid activity. Lancet 1: 384–386

    Article  PubMed  CAS  Google Scholar 

  57. Quamme GA, Wong NLM, Sutton RAL, Dirks JH (1975) Interrelationship of chlorothiazide and parathyroid hormone: a micropuncture study. Am J Physiol 229: 200–205

    PubMed  CAS  Google Scholar 

  58. Quamme GA, Dirks JH (1980) Intraluminal and contraluminal magnesium on magnesium and calcium transfer in the rat nephron. Am J Physiol 238: F187–F198

    PubMed  CAS  Google Scholar 

  59. Rocha AS. Magaldi JB, Kokko JP (1977) Calcium and phosphate transport in isolated segments of rabbit Henle’s loop. J Clin Invest 59: 975–983

    Article  PubMed  CAS  Google Scholar 

  60. Shareghi GR. Stoner LC (1978) Calcium transport across segments of the rabbit distal nephron in vitro. Am J Physiol 235: F367–F375

    PubMed  CAS  Google Scholar 

  61. Sutton RAL, Wong NLM, Dirks JH (1976) Effects of parathyroid hormone on sodium and calcium transport in the dog nephron. Clin Sci Moiecul Med 51: 345–351

    CAS  Google Scholar 

  62. Vogel G, Stockert I (1967) Die Bedeutung des Natriums Fur den renaltubularen Calcium- Transport bei Rana ridibunda. Pflügers Arch 298: 23–30

    Article  CAS  Google Scholar 

  63. Wang W, Messner G, Oberleithner H. Lang F, Deetjen P (1984) The effect of ouabain on intracellular activities of K+, Na+, CI-, H+ and Ca2- in proximal tubules of frog kidney. Pflügers Arch 401: 6–13

    Article  PubMed  CAS  Google Scholar 

  64. Windhager EE, Taylor A (1983) Regulatory role of intracellular calcium ions in epithelial Na transport. Ann Rev Physiol 45: 519–s532

    Article  CAS  Google Scholar 

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Lang, F., Paulmichl, M., Deetjen, P. (1988). Cellular Mechanisms of Renal Calcium Transport. In: Bichler, KH., Strohmaier, W.L. (eds) Nephrocalcinosis Calcium Antagonists and Kidney. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72857-0_3

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  • DOI: https://doi.org/10.1007/978-3-642-72857-0_3

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