Skip to main content

Icosanoids, Chromosome Damage and Cancer

  • Conference paper
Prostaglandins in Cancer Research

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

A relationship between chromosome damage and cancer is documented by the observation that agents known for their carcinogenic properties, such as ionizing radiation, certain viruses and many chemicals, induce chromosome damage. Three hereditary diseases, the congenital breakage syndromes, combine chromosome instability with a high risk of developing malignancy. They therefore represent another example of the association of chromosome damage and cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ames BN, Hollstein MC, Cathcart R (1982) Lipid peroxidation and oxidative damage to DNA. In: Yagi K (ed) Lipid peroxides in Biology and Medicine. Academic Press London, p 339

    Google Scholar 

  • Benedetti A, Comporti M, Esterbauer H (1980) Identification of 4-hydroxynonenal as a cytotoxic product. Biochim Biophy Acta 620: 129–140

    Google Scholar 

  • Bird R, Draper H, Basrur P (1982) Effect of malonaldehyde and acetaldehyde on culture mammalian cells; production of micronuclei and chromosomal aberrations. Mutat Res 101: 237–246

    Article  PubMed  CAS  Google Scholar 

  • Duesberg PH (1985) Activated Proto-oncogenes: sufficient or necessary for cancer? Science 228: 669–677

    Article  PubMed  CAS  Google Scholar 

  • Dzarlieva R, Fusenig N (1982) Tumor promoter 12-0-tetradecanoyl-phorbol-13-acetate enhances sister chromatid exchanges and numerical and structural chromosome aberrations in primary mouse epidermal cultures. Cancer Lett 16: 7–17

    Article  PubMed  CAS  Google Scholar 

  • Emerit I, Cerutti PA (1981) Tumor promoter phorbol-12-myristate-13-acetate induces chromosomal damage via indirect action. Nature 293: 144–145

    Article  PubMed  CAS  Google Scholar 

  • Emerit I, Cerutti P (1982) Tumor promoter phorbol-12-myristate-13-acetate induces aclastogenic factor in human lymphocytes. Proc Natl Acad Sci USA 79: 7509–7513

    Article  PubMed  CAS  Google Scholar 

  • Emerit I, Cerutti P (1983) Clastogenic action of tumor promoter phorbol-12-myristate-13-acetate in mixed human leukocyte cultures. Carcinogenesis (Lond) 4: 1313–1314

    Article  CAS  Google Scholar 

  • Emerit I, Cerutti P (1984) Icosanoids and chromosome damage. In: Thaler-Dao H, Crastes de Paulet A, Paoletti R (eds) Icosanoids and cancer. Raven, New York, pp 127–138

    Google Scholar 

  • Emerit I, Levy A, Cerutti PA (1983) Suppression of tumor promoter phorbolmyristate acetate induced chromosome breakage by antioxidants and inhibitors of arachidonic acid metabolism. Mutat Res 110: 327–335

    Article  PubMed  CAS  Google Scholar 

  • German J (1972) Genes which increase chromosomal instability in somatic cells and predispose to cancer. In: Steinberg AG, Bearn AG (eds) Progress in Medical Genetics, vol 8.Grune&Stratton, New York, p 61

    Google Scholar 

  • Hayashi O, Shimizu T (1982) Metabolic and functional significance of prostaglandins in lipid peroxide research. In: Yagi K (ed) Lipid peroxides in Biology and Medicine. Academic Press, London, p 41

    Google Scholar 

  • Khan SH, Emerit I (1986) Lipid peroxidation products and clastogenic material in culture media of human leukocytes exposed to the tumor promoter phorbolmyristate acetate. J Free Radicals Biol Med 1 (in press)

    Google Scholar 

  • Kuehl FA, Ham EA, Egan RW, Doughterty HW, Bonney RH, Humes JL (1982) Studies on a de-structive oxidant released in the enzymatic reduction of prostaglandin G2 and other hydroper- oxydases. In: Autor AP (ed) Pathology of Oxygen. Academic Press, London, p 175

    Google Scholar 

  • Lands WM (1984) Radicals and peroxides modulate the enzymic synthesis of eicosanoids from polyunsaturated fatty acids. In: Thaler-Dao H, Crastes de Paulet A, Paoletti R (eds) Icosanoids and Cancer. Raven, New York, p 41

    Google Scholar 

  • Parente L (1982) Study on the effect of superoxide dismutase on arachidonic acid metabolism. Prostaglandins 23: 725–730

    Article  PubMed  CAS  Google Scholar 

  • Ramadevi G, Das UN, Rao KP, Rao MS (1984) Prostaglandins and mutagenesis: modification of Phenytoin induced genetic damage by prostaglandins in lymphocyte cultures. Prostaglandins Leukotrienes Med 15: 109–113

    Article  CAS  Google Scholar 

  • Schauenstein E (1982) Effects of low concentrations of aldehydes on tumor cells and tumor growth. In: McBrien DCH, Slater TF (eds) Free Radicals, Lipid Peroxidation and Cancer. Academic Press, London, p 159

    Google Scholar 

  • Torielli MV, Dianzani MU (1984) Free radicals and inflammatory disease. In: Armstrong D, Sohal RS, Cutler RG, Slater TF (eds) Free Radicals in Molecular Biology, Aging and Disease. Raven, New York, p 355

    Google Scholar 

  • Weinberg RA (1985) The action of oncogene in the cytoplasm and nucleus. Science 230: 770–776

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Emerit, I. (1987). Icosanoids, Chromosome Damage and Cancer. In: Garaci, E., Paoletti, R., Santoro, M.G. (eds) Prostaglandins in Cancer Research. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71904-2_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71904-2_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71906-6

  • Online ISBN: 978-3-642-71904-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics