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Prostaglandins in Cancer Research

  • Conference proceedings
  • © 1987

Overview

Editors:
  1. Enrico Garaci

    1. Department of Experimental Medicine, II University of Rome, Rome, Italy

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  2. Rodolfo Paoletti

    1. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

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    You can also search for this editor in PubMed   Google Scholar

  3. M. Gabriella Santoro

    1. Institute of Experimental Medicine, CNR, II University of Rome, Rome, Italy

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Part of the book series: Proceedings in Life Sciences (LIFE SCIENCES)

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Table of contents (28 papers)

  1. Front Matter

    Pages I-XI
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  2. Introductory Lectures

    1. Front Matter

      Pages 1-1
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    2. On the Formation and Biological Role of Leukotrienes and Lipoxins

      • B. Samuelsson, C. Serhan
      Pages 3-11

    3. Anti-Inflammatory Drugs and the Arachidonic Acid Cascade

      • J. R. Vane
      Pages 12-25

  3. Carcinogenesis

    1. Front Matter

      Pages 27-27
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    2. Icosanoids, Chromosome Damage and Cancer

      • I. Emerit
      Pages 29-34

    3. The Arachidonate Cascade and Mouse Skin Tumor Promotion

      • S. M. Fischer
      Pages 35-47

    4. Modulation of the Conversion Stage of Multistep Carcinogenesis in Mouse Skin by Eicosanoids

      • G. Fürstenberger, M. Gschwendt, H. Hagedorn, F. Marks
      Pages 48-61

    5. Tumor Promoters, Growth Factors and Arachidonic Acid Metabolism

      • L. Levine
      Pages 62-73

  5. Cell Proliferation and Differentiation

    1. Front Matter

      Pages 139-139
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    2. Prostaglandin Production by Tumors

      • B. M. Jaffe, M. G. Santoro
      Pages 141-150

    3. Regulation by Prostaglandins of Differentiation of Mouse Myeloid Leukemia M1 Cells

      • M. Hozumi, Y. Honma, T. Kasukabe, J. Okabe-Kado, K. Takenaga
      Pages 151-160

    4. The Role of Prostaglandins and Other Arachidonic Acid Metabolites in the Differentiation of HL-60

      • T. R. Breitman
      Pages 161-171

    5. Analysis of Platelet, Tumor Cell and Endothelial Cell Interactions in Vivo and in Vitro

      • K. V. Honn, D. G. Menter, B. W. Steinert, J. D. Taylor, J. M. Onoda, B. F. Sloane
      Pages 172-183
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Keywords

About this book

Arachidonic acid metabolites are known to playa regulatory role in a number of biological systems, in which they function as microenviron­ mental hormones and intracellular signal mediators. One of the most exciting areas of research of these compounds is the one that studies the relationship between prostaglandins and tumor cell growth and function. In the last few years there has been an extraordinary evolution of data on prostaglandins (and related compounds) and cancer. This vol­ ume is based on papers presented at the 1986 International Confer­ ence on Prostaglandins and Cancer organized by the Italian National Research Council and the II University of Rome, and held in Rome, Italy, in June, 1986. This Conference brought together oncologists and specialists in the areas of prostaglandin chemistry, biochemistry, pharmacology, physiology, cellular and molecular biology to overview the actual state of knowledge on the role of eicosanoids in cancer and to focus on the key questions that need to be answered. The picture that comes out of this book describes a very complicated network of interactions between arachidonic acid metabolites and different as­ pects of the complex phenomenon "cancer". Eicosanoids participate in carcinogenesis initiation and promotion, and their relationship with tumor promoters and growth factors is well established. During cancer growth, different prostaglandins can have different roles in the regulation of cell proliferation and differentiation and in metastasis formation; meanwhile evidence is accumulating for a pos­ sible use of some of these compounds as antineoplastic agents.

Editors and Affiliations

  • Department of Experimental Medicine, II University of Rome, Rome, Italy

    Enrico Garaci

  • Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    Rodolfo Paoletti

  • Institute of Experimental Medicine, CNR, II University of Rome, Rome, Italy

    M. Gabriella Santoro

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