PGAs Inhibit in Vitro Infection with HTLV-I in Human Cord Blood Lymphocytes During Long-Term Culture

D’Onofrio, C.; Bonmassar, E.; Garaci, E.; Santoro, M. G.

doi:10.1007/978-3-642-71904-2_24

C. D’Onofrio⁴,
E. Bonmassar⁴,
E. Garaci⁴ &
…
M. G. Santoro⁵

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

42 Accesses

Abstract

The human T-cell leukemia/lymphoma virus type I (HTLV-I) is an oncogenic retrovirus that has been identified as the causative agent of a variant of adult T-cell leukemia and it is extremely tropic for T-lymphocytes, especially for the OKT4+ (helper/inducer) subset (Wong-Staal and Gallo 1985). The provirus integrates in the T-lymphocyte genome and leads to leukemic tranformation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Chapter: USD 29.95; Price excludes VAT (USA)

eBook: USD 84.99; Price excludes VAT (USA)

Softcover Book: USD 109.99; Price excludes VAT (USA)

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Abbreviations

CBL:: cord blood lymphocytes
HTLV-I:: human T-cell leukemia/lymphoma virus type I
IL-2:: interleukin-2
LAK:: lymphokine-activated killer cells
di-M-PGA₂ :: 16,16 dimethyl-PGA₂ -methyl-ester
NK:: natural killer.

References

Goodwin JS, Webb DR (1980) Regulation of the immune response by prostaglandins. Clin Immunol Immunophatol 15: 106–122
Article CAS Google Scholar
Santoro MG (1985) Role of prostaglandins in regulation of erythroleukemic cell proliferation and differentiation. In: Hayashi O, Yamamoto S (eds) Advances in Prostaglandins, Thromboxane and Leukotriene Research, vol 15. Raven, New York, pp 395–399
Google Scholar
Santoro MG, Benedetto A, Carruba G, Garaci E, Jaffe BM (1980) Prostaglandin A compounds as antiviral agents. Science 209: 1032–1034
Article PubMed CAS Google Scholar
Wong-Staal F, Gallo RC (1985) The family of the human T lymphotropic leukemia viruses: HTLV-I as the cause of adult T cell leukemia and HTLV-III as the cause of acquired immunodeficiency syndrome. Blood 65: 253–263
PubMed CAS Google Scholar

Download references

Author information

Authors and Affiliations

Department of Experimental Medicine and Biochemical Sciences, II University of Rome, Rome, Italy
C. D’Onofrio, E. Bonmassar & E. Garaci
Institute of Experimental Medicine, C.N.R., Rome, Italy
M. G. Santoro

Authors

C. D’Onofrio
View author publications
You can also search for this author in PubMed Google Scholar
E. Bonmassar
View author publications
You can also search for this author in PubMed Google Scholar
E. Garaci
View author publications
You can also search for this author in PubMed Google Scholar
M. G. Santoro
View author publications
You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

Department of Experimental Medicine, II University of Rome, Via O. Raimondo, 00173, Rome, Italy
Enrico Garaci
Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
Rodolfo Paoletti
Institute of Experimental Medicine, CNR, II University of Rome, Via O. Raimondo, 00173, Rome, Italy
M. Gabriella Santoro

Rights and permissions

Reprints and permissions

Copyright information

About this paper

Cite this paper

D’Onofrio, C., Bonmassar, E., Garaci, E., Santoro, M.G. (1987). PGAs Inhibit in Vitro Infection with HTLV-I in Human Cord Blood Lymphocytes During Long-Term Culture. In: Garaci, E., Paoletti, R., Santoro, M.G. (eds) Prostaglandins in Cancer Research. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71904-2_24

Download citation

DOI: https://doi.org/10.1007/978-3-642-71904-2_24
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71906-6
Online ISBN: 978-3-642-71904-2
eBook Packages: Springer Book Archive

Publish with us

Policies and ethics