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PGAs Inhibit in Vitro Infection with HTLV-I in Human Cord Blood Lymphocytes During Long-Term Culture

  • C. D’Onofrio
  • E. Bonmassar
  • E. Garaci
  • M. G. Santoro
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

The human T-cell leukemia/lymphoma virus type I (HTLV-I) is an oncogenic retrovirus that has been identified as the causative agent of a variant of adult T-cell leukemia and it is extremely tropic for T-lymphocytes, especially for the OKT4+ (helper/inducer) subset (Wong-Staal and Gallo 1985). The provirus integrates in the T-lymphocyte genome and leads to leukemic tranformation.

Keywords

Virus Core Protein Killing Capacity Lymphocyte Blastogenesis Target Cell Ratio Cord Blood Lymphocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

CBL

cord blood lymphocytes

HTLV-I

human T-cell leukemia/lymphoma virus type I

IL-2

interleukin-2

LAK

lymphokine-activated killer cells

di-M-PGA2

16,16 dimethyl-PGA2 -methyl-ester

NK

natural killer.

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References

  1. Goodwin JS, Webb DR (1980) Regulation of the immune response by prostaglandins. Clin Immunol Immunophatol 15: 106–122CrossRefGoogle Scholar
  2. Santoro MG (1985) Role of prostaglandins in regulation of erythroleukemic cell proliferation and differentiation. In: Hayashi O, Yamamoto S (eds) Advances in Prostaglandins, Thromboxane and Leukotriene Research, vol 15. Raven, New York, pp 395–399Google Scholar
  3. Santoro MG, Benedetto A, Carruba G, Garaci E, Jaffe BM (1980) Prostaglandin A compounds as antiviral agents. Science 209: 1032–1034PubMedCrossRefGoogle Scholar
  4. Wong-Staal F, Gallo RC (1985) The family of the human T lymphotropic leukemia viruses: HTLV-I as the cause of adult T cell leukemia and HTLV-III as the cause of acquired immunodeficiency syndrome. Blood 65: 253–263PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • C. D’Onofrio
    • 1
  • E. Bonmassar
    • 1
  • E. Garaci
    • 1
  • M. G. Santoro
    • 2
  1. 1.Department of Experimental Medicine and Biochemical SciencesII University of RomeRomeItaly
  2. 2.Institute of Experimental MedicineC.N.R.RomeItaly

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