PGAs Inhibit in Vitro Infection with HTLV-I in Human Cord Blood Lymphocytes During Long-Term Culture

  • C. D’Onofrio
  • E. Bonmassar
  • E. Garaci
  • M. G. Santoro
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


The human T-cell leukemia/lymphoma virus type I (HTLV-I) is an oncogenic retrovirus that has been identified as the causative agent of a variant of adult T-cell leukemia and it is extremely tropic for T-lymphocytes, especially for the OKT4+ (helper/inducer) subset (Wong-Staal and Gallo 1985). The provirus integrates in the T-lymphocyte genome and leads to leukemic tranformation.


Virus Core Protein Killing Capacity Lymphocyte Blastogenesis Target Cell Ratio Cord Blood Lymphocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



cord blood lymphocytes


human T-cell leukemia/lymphoma virus type I




lymphokine-activated killer cells


16,16 dimethyl-PGA2 -methyl-ester


natural killer.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • C. D’Onofrio
    • 1
  • E. Bonmassar
    • 1
  • E. Garaci
    • 1
  • M. G. Santoro
    • 2
  1. 1.Department of Experimental Medicine and Biochemical SciencesII University of RomeRomeItaly
  2. 2.Institute of Experimental MedicineC.N.R.RomeItaly

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