Abstract
The oxygenation of arachidonic acid and other polyunsaturated fatty acids by a wide variety of cells results in the formation of several structurally distinct classes of biologically active compounds (Samuelsson 1983; Samuelsson et al. 1985). These compounds include the prostaglandins, thromboxanes, leukotrienes, and other oxygenated derivatives of polyunsaturated fatty acids. A most recent addition to this family of biologically active compounds is the lipoxins (Serhan et al. 1984a). Both leukotrienes and lipoxins are formed by transformations which involve lip oxygenation. In general, lipoxygenase products display a wide range of biological actions and appear to be involved in immunity, the regulation of inflammation, and other physiological and pathophysiological processes. This chapter describes results of recent studies on the 5-lipoxygenase (a key enzyme complex involved in the formation of these compounds) and the biosynthesis, stereochemistry and biological activities of the lipoxins.
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References
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Samuelsson, B., Serhan, C. (1987). On the Formation and Biological Role of Leukotrienes and Lipoxins. In: Garaci, E., Paoletti, R., Santoro, M.G. (eds) Prostaglandins in Cancer Research. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71904-2_1
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DOI: https://doi.org/10.1007/978-3-642-71904-2_1
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