Abstract
Polyunsaturated phosphatidylcholine (PPC) is a lecithin which is extracted from soybeans and is very rich in polyunsaturated fatty acids. Earlier investigations in man have shown that PPC lowers significantly total and LDL-cholesterol (1–14). Triglycerides are also frequently (1–6, 8–10, 12), although not always, reduced (15, 16). Reports on the behaviour of HDL during treatment with PPC are contradictory (15, 17). The purpose of the present study was to test the lipid-lowering effect of PPC in doses higher than previously used.
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References
Nakamura H, Ebatz Y, Tonomo A, Hatz Y, Shiegematsu H, Hara T, Takeuchi I, Unretada Y (1973) Effects of EPL capsule on serum lipid level. J Med REm Clin 22:1565–1574
Yasugi T, Iijima M, Kinoshita T, Harada S, Matsumoto H, Sugeta K, Takeshita H, Saijo M, Shimizu T, Sassa E, Tomita M, Kobari M, Kobayashi I, Seto Y, Kuono H, Hoshino K (1973) Effects of EPL on serum lipid. Jpn J Med Treat 22:691–969
Sekimoto H, Nakada J, Nakai T, Nakamura K, Yamada S, Mori K (1972) Study of clinical effects of EPL for the improvement of abnormality in serum lipid in a double-blind technique. Jpn J Med Treat 5:1725–1734
Hevelke G, Grott E, Machalke K, Zappe R (1975) Zur Wirkung “essentieller” Phospholipide auf den Blutfettgehalt des Menschen. Folia Angiol, Suppl IV: 80–87
Knüchel F (1955) Untersuchungen über die medikamentöse Beeinflußbarkeit der Serumlipide bei der Arteriosklerose. Therapiewoche 5:570–574
Andersen P (1965) Die Behandlung von arteriosklerotischen Kreislaufstörungen und Hyperli-pämien mit Phosphatidylcholin. Ther Umsch 22:614–622
Spigai C (1970) Einfluss der “essentiellen” Phospholipide auf den Lipidspiegel. Med Heute 19: 197–198
Casellas Bernat G, Riera de Barcia L, Alou M, Solivellas S, Casellas Bernat A (1975) Dislipe-mias y fosfatidilcolina insaturada. Clin Med 15:90–95
Uchida S (1968) Efficacy of EPL for lipid metabolism disorder. Shinryo Shin’yaku 5:1073–1076
Unger E, Walter M, Jaross W, Hanefeld M, Rossbach G (1971) Der Einfluß von essentiellen Phospholipiden auf die Fettfraktionen des Serums und der Leber. Zentralbl Pharmakol 110: 453–458
Uemura K (1973) Clinical experiences on polyenyl-phosphatidyl-choline (EPL). J New Remed Clin 22:1583–1597
Saba P, Galeone F, Salvadosini F, Pagliai E, Guidi O, Scalabrino A (1978) Effects of soybean polyunsaturated phosphatidylcholine (Lipostabil) on hyperlipoproteinemia. Curr Ther Res 4:299–306
Varkonyi Gy (1962) Beitrag zur therapeutischen Wirkung der oralen und intravenösen Verabreichung “essentieller” Cholinphospholipide. Z Ges Inn Med 18:830–838
Pupita F, Gagna G (1969) Therapie der Arteriosklerose mit “essentiellen” Phospholipiden. Med Monatsschr 23:514–515
Fasoli A (1982) Clinical evaluation of polyenoyl phosphatidyl-choline: effects on serum lipid and lipoprotein patterns. In: Ricci G, et al. (eds) Therapeutic selectivity and risk/benefit assessment of hypolipidemic drugs. Raven, New York, p 257
Blaton V, Soeteway F, Vandanne D, Declercq B, Peeters H (1976) Effect of polyunsaturated phosphatidylcholine on human types II and IV hyperlipoproteinemias. Artery 2:309
Dewailly P, Moulin S, Rouget JP, Sezille G, Jaillard J (1983) Effects of polyenyl-phosphati-dylcholine on lipoproteins of patients with hypercholesterolemia. Eur J Clin Pharmacol (submitted)
Sirtori CR (1983) Phospholipids, atherosclerosis and aging. In: Avogaro P, et al. (eds) Phospholipids and atherosclerosis. Raven, New York, p 197
Schneider J (1982) Experimental and clinical effects of polyenoylphosphotidylcholine on erythrocytes and platelets. In: Ricci G, et al. (eds) Therapeutic selectivity and risk/benefit assessment of hypolipidemic drugs. Raven, New York, p 263
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Noseda, G., Fragiacomo, C. (1987). Effect of Polyunsaturated Phosphatidylcholine (PPC) on Plasma Lipoproteins in Patients with Type II Hyperlipoproteinemia. In: Paoletti, R., Kritchevsky, D., Holmes, W.L. (eds) Drugs Affecting Lipid Metabolism. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71702-4_78
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DOI: https://doi.org/10.1007/978-3-642-71702-4_78
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