Drugs Affecting Lipid Metabolism

1. Front Matter

   Pages I-XVI

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2. Relationship of Cholesterol to DNA Synthesis in Normal and Cancerous Cells

   • M. D. Siperstein, H. DoVale, J. R. Silber

   Pages 1-8

3. Turnover of HMG CoA Reductase is Influenced by Phosphorylation

   • R. A. Parker, S. J. Miller, D. M. Gibson

   Pages 9-13

4. Regulation of ACAT

   • K. A. Mitropoulos

   Pages 14-20

5. Dietary and Pharmacological Control of Cholesterol 7α-Hydroxylase

   • E. Bosisio

   Pages 21-28

6. Recent Advances in Metabolic Pathways of Bile Acid Synthesis

   • N. B. Javitt

   Pages 29-33

7. Bile Acid Sequestrants: Do They Have a Future?

   • S. M. Grundy

   Pages 34-41

8. Transport of Cholesterol and Cholesterol Esters by HDL

   • D. Steinberg

   Pages 42-47

9. Role of HDL in the Metabolism of the Plasma Lipoproteins

   • S. Eisenberg

   Pages 48-51

10. The Structure of ApoB-100: Structure-Function Studies

    • A. M. Gotto, W. A. Bradley, L. Chan, S. H. Gianturco, H. J. Pownall, J. T. Sparrow et al.

    Pages 52-55

11. A Genetic Marker in the Apolipoprotein AI/CIII Gene Complex Associated with Hypercholesterolaemia

    • C. C. Shoulders, M. J. Ball, J. I. Mann, F. E. Baralle

    Pages 56-58

12. Cellular and Molecular Biology of Apolipoproteins: Receptor-Mediated Regulation of Cholesterol Metabolism

    • R. W. Mahley

    Pages 59-62

13. APOA-I and APOA-II Metabolism and Coronary Artery Disease

    • G. Ghiselli, J. Heibig, F. Turturro, A. M. Gotto Jr., E. Wittels

    Pages 63-68

14. Hypocholesterolemic Drugs and Lipoprotein Metabolism

    • D. Steinberg

    Pages 69-78

15. Hypotriglyceridemic Drugs and Lipoprotein Catabolism

    • S. Eisenberg

    Pages 79-82

16. Lipolysis and Lipoprotein Metabolism

    • P. Nilsson-Ehle

    Pages 83-87

17. Regulation of Lipoprotein Lipase Activity: Its Role in Lipid-Lowering Therapies

    • Th. Olivecrona, S. R. Price, P. H. Pekala, R. O. Scow, S. S. Chernick, H. Semb et al.

    Pages 88-93

18. Lipolysis and Antilipolytic Drugs at Different Ages

    • R. M. Gaion, P. Dorigo

    Pages 94-97

19. Fatty Acid-Binding Proteins of Various Tissues

    • J. H. Veerkamp, R. J. A. Paulussen

    Pages 98-104

20. Interaction of Lipid-Lowering Drugs with Fatty Acid-Binding Proteins

    • N. M. Bass, R. K. Ockner

    Pages 105-110

The recent symposium and the appearance of this new book on Drugs Affecting Lipid Metabolism take place at a very unusual time for the development of this area. After the publication and wide acceptance of the results of the cholestyramine study by the Lipid Clinics in the USA, showing for the first time a direct association between drug induced reduction of plasma levels of total and LDL cholesterol and coronary heart disease in a high risk population, an unparalleled interest in drugs and other procedures able to control plasma cholesterol levels has been activated. Two other significant events occurred during 1986 and 1987: the availability of compact instruments for the immediate determination of total cholesterol in plasma or total blood and the developments of new agents such as the inhibitors of HMG-CoA (hydroxymethyl­ glutaryl CoA) reductase and ACAT inhibitors, with potentially great effect on plasma lipid levels after oral administration. These new advances, together with the combined efforts of cell biologists and lipoprotein chemists, have set the pace for an exciting period of research and clinical applications of diets and drugs af­ fecting lipids. This volume, which includes the work of many of the leading world laboratories, represents an authoritative and up-to-date ap­ praisal of the status of the art and a stimulus to future research at laboratory and clinical level in an area of opportunity for clinical and preventive medicine.

• Lipid
• Lipoprotein
• development
• drug
• lipide
• metabolism
• protein
• research

• School of Pharmacy, University of Milan, Milan, Italy

  Rodolfo Paoletti

• The Wistar Institute, Philadelphia, USA

  David Kritchevsky

• West Chester, USA

  William L. Holmes

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