Abstract
Heightened platelet function is suggested to be associated with the well-known thrombotic complications and the accelerated atherogenesis of type II hyperlipoproteinemia (Carvalho et al. 1974). With regard to the two main theories on the pathogenesis of atherosclerosis, the hypothesis of damaged endothelium and the lipid hypothesis, one has to distinguish between cause and effect. On the one side, it is not imperative that endothelial damage by rheological, metabolic, traumatic, or inflammatory causes resuits in atherosclerotic plaques. On the other hand, one can expect this with a much higher probability if such endothelial lesions occur in patients with hypercholesterolemia. The pathogenesis of atherosclerosis is founded upon many facts and atherosclerosis is the multifactorial result of parts of the lipid hypothesis as well as of the hypothesis of damaged endothelium.
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© 1987 Springer-Verlag Berlin Heidelberg
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Krüger, B., Thiemann, R. (1987). Hyperaggregability of Platelets in Patients with Hyperlipoproteinemia Type IIb Under Treatment with Etofibrate Retard and Acetylsalicylic Acid. In: Paoletti, R., Kritchevsky, D., Holmes, W.L. (eds) Drugs Affecting Lipid Metabolism. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71702-4_73
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DOI: https://doi.org/10.1007/978-3-642-71702-4_73
Publisher Name: Springer, Berlin, Heidelberg
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