Abstract
This chapter is concerned with the results collected so far on the pharmacokinetics and metabolism of 2-tert-butyl-4-cyclohexyl nicotinate (L44) (Fig. 1), a substance exhibiting hypolipidemic properties (Quack et al. 1986). For this study we utilized the compound labeled with [14C] in the phenolic ring. In order to check the chemical and radiochemical purity of the labeled compound different chromatographic techniques, combined with radioactivity monitoring detectors, were employed.
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Reference
Quack G, Puglisi L, Schatton W, Schwaier A (1986) Evaluation of the hypolipidemic properties of various nicotinic acid derivatives in the rat. Abstr Book IXth Int Symp Drugs affecting lipid metabolism, p 67
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© 1987 Springer-Verlag Berlin Heidelberg
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Galli, G., Bosisio, E., De Fabiani, E., Crestani, M., Quack, G., Schatton, W. (1987). Pharmacokinetics and Metabolism of 2-Tert-Butyl-4-Cyclohexyl-Phenyl Nicotinate (L-44) in Rats. In: Paoletti, R., Kritchevsky, D., Holmes, W.L. (eds) Drugs Affecting Lipid Metabolism. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71702-4_71
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DOI: https://doi.org/10.1007/978-3-642-71702-4_71
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