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Species Differences in the Metabolic Disposition of Fenofibrate

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Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


Fenofibrate (isopropyl 4-(p-chlorobenzoyl)phenoxyisobutyrate: Lipanthyl) is a hypolipidaemic agent structurally related to Clofibrate. In view of current concern over the safety-in-use of this class of drug, there is a need for information about their metabolic disposition, in terms of rates and routes of metabolism and excretion and various factors which might influence these, such as species differences, chronic administration and dose dependency. As an adjunct to both the toxicological evaluation and clinical pharmacological investigation of fenofibrate, we now present the results of a study of its fate in rat, dog and man, and some potential influencing factors.


  • Fenofibric Acid
  • Enantiomeric Composition
  • High Performance Liquid Chromatographic Separation
  • Gelatine Capsule
  • Potential Influence Factor

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  • DOI: 10.1007/978-3-642-71702-4_60
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  • Caldwell J (1985) Glucuronic acid conjugation in the context of the metabolic conjugation of xenobiotics. In: Matern S, Bock KW, Gerok W (eds) Advance in Glucuronide Conjugation. MTP, Lancaster, UK, pp 7–20

    Google Scholar 

  • Caldwell J, Hutt AJ (1986) Methodology for the isolation and characterization of conjugates of xenobiotic carboxylic acids. In: Bridges JW, Chasseaud LF (eds) Progress in Drug Metabolism, vol 9. Taylor and Francis, London, pp 11–51

    Google Scholar 

  • Emudianughe TS, Caldwell J, Sinclair KA, Smith RL (1983) Species differences in the metabolic conjugation of clofibric acid and Clofibrate in laboratory animals and man. Drug Metab Dispos 11:97–102

    PubMed  CAS  Google Scholar 

  • Hutt AJ, Fournel S, Caldwell J (1986) The application of a radial compression column to the high performance liquid chromatographic separation of the enantiomers of some 2-arylpropionic acids as their diastereoisomeric R-(+)-1-[naphthen-1-yl]ethylamides. J Chrom 378:409–418

    CrossRef  CAS  Google Scholar 

  • Sangster SA, Caldwell J, Hutt AJ, Smith RL (1983) The metabolism of p-propylanisole in the rat and mouse and its variation with dose. Fd Chem Toxicol 21:263–271

    CrossRef  CAS  Google Scholar 

  • Sinclair KA, Caldwell J (1982) The formation of β-glucuronidase resistant glucuronides by the intramolecular rearrangement of glucuronic acid conjugates. Biochem Pharmacol 31:953–957

    PubMed  CrossRef  CAS  Google Scholar 

  • Van Breemen R, Fenselau C (1985) Acylation of albumin by 1-O-acyl glucuronides. Drug Metab Dispos 13:318–320

    PubMed  Google Scholar 

  • Van der Waterbeemd H, Testa B, Caldwell J (1986) The influence of conformational factors on the metabolic conjugation of aryloxyacetates. J Pharm Pharmacol 38:14–18

    PubMed  CrossRef  Google Scholar 

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© 1987 Springer-Verlag Berlin Heidelberg

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Weil, A., Caldwell, J., Strolin-Benedetti, M., Dostert, P. (1987). Species Differences in the Metabolic Disposition of Fenofibrate. In: Paoletti, R., Kritchevsky, D., Holmes, W.L. (eds) Drugs Affecting Lipid Metabolism. Proceedings in Life Sciences. Springer, Berlin, Heidelberg.

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