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Species Differences in the Metabolic Disposition of Fenofibrate

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Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

Fenofibrate (isopropyl 4-(p-chlorobenzoyl)phenoxyisobutyrate: Lipanthyl) is a hypolipidaemic agent structurally related to Clofibrate. In view of current concern over the safety-in-use of this class of drug, there is a need for information about their metabolic disposition, in terms of rates and routes of metabolism and excretion and various factors which might influence these, such as species differences, chronic administration and dose dependency. As an adjunct to both the toxicological evaluation and clinical pharmacological investigation of fenofibrate, we now present the results of a study of its fate in rat, dog and man, and some potential influencing factors.

Keywords

  • Fenofibric Acid
  • Enantiomeric Composition
  • High Performance Liquid Chromatographic Separation
  • Gelatine Capsule
  • Potential Influence Factor

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© 1987 Springer-Verlag Berlin Heidelberg

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Weil, A., Caldwell, J., Strolin-Benedetti, M., Dostert, P. (1987). Species Differences in the Metabolic Disposition of Fenofibrate. In: Paoletti, R., Kritchevsky, D., Holmes, W.L. (eds) Drugs Affecting Lipid Metabolism. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71702-4_60

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  • DOI: https://doi.org/10.1007/978-3-642-71702-4_60

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71704-8

  • Online ISBN: 978-3-642-71702-4

  • eBook Packages: Springer Book Archive