The Role of the Antioxidant Tocopherol in Lipid and Lipoprotein Metabolism
Vitamin E, tocopherol, was demonstrated to be an essential nutrient in several animal species some 6 decades ago, but it has only been in the past 10 years that vitamin E deficiency in humans, resulting in neurologic abnormalities (spinocerebellar ataxia and areflexia), has been generally recognized to occur as a result of lipid malabsorption syndromes. In this chapter the transport mechanisms for tocopherol will be reviewed and related to lipid malabsorption syndromes and abnormalities in lipid and lipoprotein metabolism. The symptomatology resulting from vitamin E deficiency and the evidence for in vivo lipid peroxidation will be discussed.
KeywordsLipoprotein Lipase Sural Nerve Short Bowel Syndrome Lipoprotein Metabolism Spinocerebellar Ataxia
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