Dietary and Biochemical Studies with Textured Soy Proteins

  • C. R. Sirtori
  • A. Canavesi
  • C. Manzoni
  • M. R. Lovati
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


The hypocholesterolemic activity of vegetable proteins, particularly from soybean, was suggested early this century from animal studies (Ignatowski 1909; Meeker and Kesten 1940). In more recent years, several authors have demonstrated that the substitution of animal proteins with soybean proteins in the diet significantly reduces plasma cholesterol levels both in experimental animals (Terpstra et al. 1984) and in man (Sirtori et al. 1977). The soybean protein diet appears to be an effective alternative to drug treatments in adult type II hypercholesterolemic patients (Sirtori et al. 1977; Descovich et al. 1980), the activity being independent of dietary cholesterol and only partially influenced by the P/S ratio (Sirtori et al. 1979).


Animal Protein Soybean Protein Liver Membrane Texture Vegetable Protein Soybean Diet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Descovich GC, Ceredi C, Gaddi et al. (1980) Multicenter study of soybean protein diet for outpatient hypercholesterolaemic patients. Lancet ii:709–712CrossRefGoogle Scholar
  2. Fumagalli R, Paoletti R, Howard AN (1978) Hypocholesterolemic effect of soya. Life Sci 22:947–952PubMedCrossRefGoogle Scholar
  3. Fumagalli R, Soleri L, Farina R et al. (1982) Fecal colesterol excretion studies in type II hypercholesterolemic patients treated with the soybean protein diet. Atherosclerosis 43:341–352PubMedCrossRefGoogle Scholar
  4. Gaddi A, Descovich GC, Noseda G et al. (1987) Hypercholesterolaemia treated by soybean protein diet. Arch Dis Childh 62:274–278PubMedCrossRefGoogle Scholar
  5. Gibney MJ, Kritchevsky D (1983) Animal and vegetable proteins in lipid metabolism and atherosclerosis. Liss, New YorkGoogle Scholar
  6. Huff MW, Carroll KK (1980) Effect of the dietary protein on turnover, oxidation and absorption of cholesterol and on steroid oxidation in rabbits. J Lipid Res 21:546–558PubMedGoogle Scholar
  7. Ignatowski A (1909) Über die Wirkung des tierischen Eiweißes auf die Aorta und die parenchymatosen Organe der Kaninchen. Virchows Arch 198:248–270CrossRefGoogle Scholar
  8. Kim DN, Lee KT, Reiner JM et al. (1978) Effect of a soy product on serum and tissue cholesterol concentrations in swine fed high-fat, high-cholesterol diets. Exp Mol Pathol 29:385–399PubMedCrossRefGoogle Scholar
  9. Kovanen PT, Brown MS, Goldstein JL (1979) Increased binding of low density lipoprotein to liver membranes from rats treated with 17 α-ethinyl estradiol. J Biol Chem 254:11367–11373PubMedGoogle Scholar
  10. Lovati MR, Allievi L, Sirtori CR (1985) Accelerated early catabolism of very low density lipoproteins in rats after dietary soy proteins. Atherosclerosis 56:243–246PubMedCrossRefGoogle Scholar
  11. Meeker DR, Kesten HD (1940) Experimental atherosclerosis and high protein diets. Proc Soc Exp Biol Med 45:543–545Google Scholar
  12. Meinertz H, Nilausen K, Faergeman O (1984) Effects of dietary soy protein and casein on plasma lipoproteins in normolipidemic subjects. Circulation 70:1161 (Abstr)Google Scholar
  13. Redgrave TG (1984) Dietary proteins and atherosclerosis. Atherosclerosis 52:349PubMedCrossRefGoogle Scholar
  14. Sirtori CR, Agradi E, Conti F et al. (1977) Soybean protein diet in the treatment of type II hyperlipoproteinaemia. Lancet i:275–277CrossRefGoogle Scholar
  15. Sirtori CR, Gatti E, Mantero O et al. (1979) Clinical experience with the soybean protein diet in the treatment of hypercholesterolemia. Am J Clin Nutrit 92:1645–1658Google Scholar
  16. Sirtori CR, Galli G, Lovati MR et al. (1984) Effects of dietary proteins on the regulation of liver lipoprotein receptors in rats. J Nutrit 114:1493–1500PubMedGoogle Scholar
  17. Sirtori CR, Zucchi-Dentone C, Sirtori M et al. (1985) Cholesterol-lowering and HDL-raising properties of lecithinated soy proteins in type II hyperlipidemic patients. Ann Nutrit Metab 29:348–357CrossRefGoogle Scholar
  18. Terpstra AHM, Tintelen G van, West CE (1982) The hypocholesterolemic effect of dietary soy protein in rats. J Nutrit 112:810–817PubMedGoogle Scholar
  19. Terpstra AHM, West CE, Fennis JTCM et al. (1984) Hypocholesterolemic effect of dietary soy protein versus casein in rhesus monkeys. Am J Clin Nutrit 39:1–7PubMedGoogle Scholar
  20. Van Raaij JAM, Katan MB, West CE et al. (1982) Influence of diets containing casein, soy isolate and concentrate on serum cholesterol and lipoproteins in middle-aged volunteers. Am J Clin Nutrit 35:925–934PubMedGoogle Scholar
  21. Widhalm K (1986) Effect of diet on serum lipids and lipoprotein in hyperlipoproteinemic children. In: Beynen AC (ed) Nutritional effects on cholesterol metabolism. Transmondial, Voorthuizen, pp 133–140Google Scholar
  22. Zierenberg O, Assmann G, Schmitz G et al. (1981) Effect of polyenephosphatidylcholine on cholesterol uptake by human high density lipoprotein. Atherosclerosis 39:527–542PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • C. R. Sirtori
  • A. Canavesi
  • C. Manzoni
  • M. R. Lovati
    • 1
    • 2
  1. 1.Center E. Grossi Paoletti, Institute of Pharmacological SciencesUniversity of MilanoMilanoItaly
  2. 2.Divisione Medica VerganiOspedale di Niguarda Ca’ GrandaMilanoItaly

Personalised recommendations