Abstract
Lovastatin (mevinolin) is a competitive inhibitor of HMG CoA (hydroxymethyl-gluturate coenzyme A) reductase. Lovastatin decreases cholesterol synthesis and increases the number of LDL (low density lipoprotein) receptors and the catabolism of LDL (1,2). A variety of clinical trials demonstrate that lovastatin administration in humans is associated with significant reductions in LDL cholesterol up to 40% (3). The efficacy of lovastatin in humans appears to be established, but additional studies in humans related to long-term safety and mechanism of action are still in progress. This report addresses several of these issues in a preliminary fashion.
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© 1987 Springer-Verlag Berlin Heidelberg
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Hunninghake, D.B. et al. (1987). Metabolic Studies with Lovastatin in Patients with Primary Hypercholesteremia. In: Paoletti, R., Kritchevsky, D., Holmes, W.L. (eds) Drugs Affecting Lipid Metabolism. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71702-4_27
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DOI: https://doi.org/10.1007/978-3-642-71702-4_27
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