Abstract
The cytoplasm of eukaryotic cells contains three fibrous systems: microfilaments, intermediate filaments and microtubules. Microfilaments are polymers of actin, microtubules are made up of tubulin subunits and intermediate filaments are composed of at least five different classes of proteins according to tissue origin. It is now widely recognized that cytoskeletal and their associated proteins play an important role in cell motility, cell shape, endo- and exocytotic processes, organelle movement, and control of surface receptor functions[1].
Supported in part by the Swiss National Science Foundation, Grant no. 3.178-0.82, by the Ernst and Lucie Schmidheiny Foundation and by the Deutsche Forschungsgemeischaft, Bonn-Bad Godesberg.
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Rungger-Brändle E, Gabbiani G (1983) The role of cytoskeletal and cytocontractile elements in pathologic processes. Am J Pathol 110: 361 – 392
Scott McNutt N (1981) In vivo studies of actin-containing cytoskeletal abnormalities in neoplastic cells. Eur J Cell Biol 25: 218 – 222
Southwick FS, Stossel TP (1983) Contractile proteins in leukocyte function. Semin Hematol 20: 305 – 321
Howard TH, Oresajo CO (1985) The kinetics of chemotactic-induced change in F-actin content, F-actin distribution, and the shape of neutrophils. J Cell Biol 101: 1078–1085
Gabbiani G, Kapanci Y, Barazzone P, Franke W (1981) Immunochemical identification of intermediate-sized filaments in human neoplastic cells. A diagnostic aid for the surgical pathologist. Am J Pathol 104: 206–216
Fox JEB, Dockter ME, Phillips DR (1981) An improved method for determining the actin filament content in nonmuscle cells by the DNase I inhibition assay. Anal Biochem 117: 170 – 177
Kocher O, Skalli O, Cerutti D, Gabbiani F, Gabbiani G (1985) Cytoskeletal features of aortic cells during development. An electron microscopic, immunohistochemical, and biochemical study. Circ Res 56: 829–838
Nagata K, Sagara J, Ichikawa Y (1982) Changes in contractile proteins during differentiation of myeloid leukemia cells. H. Purification and characterization of actin. J Cell Biol 93: 470–478
Meyer WH, Howard TH (1983) Changes in actin content during induced myeloid maturation of human promyelocytes. Blood 62: 308–314
Dellagi K, Vainchenker W, Vinci G, Paulin D, Brouet JC (1983) Alteration of vimentin intermediate filament expression during differentiation of human hemopoietic cells. EMBO J 2: 1509 – 1514
Skalli O, Bloom WS, Ropraz P, Azzarone B, Gabbiani G (1986) Cytoskeletal remodeling of rat aortic smooth muscle cells in vitro: relationships to culture conditions and analogies to in vivo situations. J Submicrosc Cytol 18: 481 – 493
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© 1987 Springer-Verlag Berlin Heidelberg
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Schmitt-Gräff, A., Scheulen, M.E., Gabbiani, G. (1987). Cytoskeletal Organization in Acute Leukemias. In: Büchner, T., Schellong, G., Hiddemann, W., Urbanitz, D., Ritter, J. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71213-5_46
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DOI: https://doi.org/10.1007/978-3-642-71213-5_46
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-16556-9
Online ISBN: 978-3-642-71213-5
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