Abstract
Most studies of the genetic effects of anticancer drugs have been concerned with their ability to cause cytogenetic damage. Gene mutations have been screened in bacteria [14], Drosophila [5, 6], and cultured mammalian cells [7, 8].
Financial support for this study was received from the Cancer Research Campaign and the Musgrove Leukaemia Fund.
Preview
Unable to display preview. Download preview PDF.
References
Herbold B, Buselmaier W (1976) Induction of point mutations by different chemical mechanisms in the liver microsomal assay. Mutat Res 40: 73–84
Benedict WF, Baker MS, Haroun L, Choi E, Ames BN (1977) Mutagenicity of cancer chemotherapeutic agents in the Salmonellamicrosome test. Cancer Res 37: 2209–2213
Seino Y, Nagao M, Yahagi T, Hoshi A, Kawachi T, Sugimura T (1978) Mutagenicity of several classes of anti-tumour agents to Salmonella TA98, TA100, TA92. Cancer Res 38: 2148–2156
Pak K, Iwasaki T, Mitakawa M, Yoshida O (1979) The mutagenic activity of anti-cancer drugs and the urine of rats given these drugs. Urol Res 7: 119–124
Vogel E, Schalet A, Lee WR, Wurgler F (1981) Mutagenicity of selected chemicals in Drosophila. In: de Serres FJ, Shelby MD (eds) Comparative chemical mutagenesis. Plenum, New York, pp 175–255
Todd NK, Clements J, Zoeller P, Phillips MJ (1983) Absence of a mutagenic effect after feeding 4 anticancer drugs to Drosophila melanogaster. Mutat Res 120: 121–125
Suter W, Brennand J, McMillan S, Fox M (1980) Relative mutagenicity of antineoplastic drugs and alkylating agents in V79 Chinese hamster cells independent of cytotoxic and mutagenic responses. Mutat Res 73: 171–181
Dickins M, Wright KP, Phillips MJ, Todd NK (1985) Toxicity and mutagenicity tests for four anticancer drugs in cultured Chinese hamster cells. Mutat Res 143: 149–154
Glatt H, Billings R, Platt KL, Oesch F (1981) Improvement of the correlation of bacterial mutagens with carcinogenicity of benzo(a) pyrene and four of its major metabolites by activation with intact liver cells instead of cell homogenate. Cancer Res 41: 270–211
Dickins M, Peterson RE (1980) Effects of a hormone supplemented medium on cytormone P-450 content and monooxygenase activities of rat hepatocytes in primary cul-pyrene and four of its major metabolites by ture. Biochem Pharmacol 29: 1231–1238
Dickins M, Wright K, Phillips MJ, Todd NK homogenate. Cancer Res 41:270–277 (1985) Toxicity and mutagenicity of 6 anticancer drugs in Chinese hamster V79 cells co- tochrome P-450 content and monooxygenase 157: 189–197
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Phillips, M.J., Dickins, M., Wright, K., Todd, N.K. (1987). Toxicity and Mutagenicity of 6 Anti-Cancer Drugs in Chinese Hamster Cells Co-Cultured with Rat Hepatocytes. In: Büchner, T., Schellong, G., Hiddemann, W., Urbanitz, D., Ritter, J. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71213-5_41
Download citation
DOI: https://doi.org/10.1007/978-3-642-71213-5_41
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-16556-9
Online ISBN: 978-3-642-71213-5
eBook Packages: Springer Book Archive