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Prognostic Factors in Acute Lymphoblastic Leukemia in Adults: The Memorial Hospital Experience

  • Conference paper
Acute Leukemias

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 30))

Abstract

Acute lymphoblastic leukemia (ALL) has become a curable disease through the development of effective treatment strategies based on polychemotherapy with non-crossresistant drugs, effective prophylaxis of central nervous system leukemia, and prolonged maintenance chemotherapy [1–4]. Lymhoblastic leukemia in children, in particular, has been treated successfully, with the majority of children surviving 5 years [5]. It was recognized during the early studies that patients had very different responses to standard therapy, and a number of models were developed to identify patient groups with different prognoses. As a consequence, children with ALL were treated differently, based on their classification as “low,”-“standard,”- or “high”-risk patients. Risk group assignments were mainly based on age, white blood cell count (WBC), and involvement of lymph nodes, hepatomegaly or splenomegaly in some series [5].

Supported in part by grants from the NIH CA-38980, CA-20194, and CA-05826.

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References

  1. Schauer P, Arlin ZA, Mertelsmann R, Cirrincione C, Friedman A, Gee T, Dowling M, Kempin S, Straus DJ, Koziner B, McKenzie S, Thaler HT, Dufour P, Little C, Dellaquila C, Ellis S, Clarkson B (1983) Treatment of acute lymphoblastic leukemia in adults: results of the L-10 and L-10M protocols. J Clin Oncol 1: 462–470

    PubMed  CAS  Google Scholar 

  2. Clarkson B, Gee T, Arlin Z, Mertelsmann R, Kempin S, Dinsmore R, O’Reilly R, Andreeff M, Berman E, Higgins C, Little C, Cirrincione C, Ellis S (1984) Current status of treatment of acute leukemia in adults: an overview. In: Buechner Th (ed) Therapy of Acute Leukemia. Springer, Berlin Heidelberg New York Tokyo, pp 1–31

    Google Scholar 

  3. Clarkson B, Ellis S, Little C, Gee T, Arlin Z, Mertelsmann R, Andreeff M, Kempin S, Koziner B, Chaganti R, Jhanwar S, McKenzie S, Cirrincione C, Gaynor J (1985) Acute lymphoblastic leukemia in adults. Semin On-col 12: 160–179

    CAS  Google Scholar 

  4. Hoelzer D, Thiel E, Loeffler H, Bodenstein H, Plaumann L, et al. (1984) Intensified therapy in acute lymphoblastic and acute undifferenti-ated leukemia in adults. Blood 64: 38–47

    PubMed  CAS  Google Scholar 

  5. Riehm H, Gadner H, Henze G, Kornhuber B, Langermann H-J, Mueller-Weihrich S and Schellong G (1983) Acute lymphoblastic leukemia: treatment results in three BFM studies (1970–1981). In: Murphy SB, Gilbert JR (eds) Leukemia research: advances in cell biology and treatment. Elsevier Science, New York, pp 251–260 20.

    Google Scholar 

  6. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (FAB Cooperative Group) (1976) Proposals for the classification of the acute leukaemias. Br J Haemat 33: 415

    Article  Google Scholar 

  7. Jhanwar S, Conjalka M, Chaganti R, et al. (to be published) Cytogenetic analysis and prognostic correlations in acute lymphoblastic leukemia (ALL) in adults and children

    Google Scholar 

  8. Andreeff M, Darzynkiewicz Z, Sharpless TK, Clarkson B, Melamed MR (1980) Discrimination of human leukemia subtypes by flow cytometric analysis of cellular DNA and RNA. Blood 55: 282–293

    PubMed  CAS  Google Scholar 

  9. Hiddemann W, Schumann J, Andreeff M, Barlogie B, Herman C, Leif RC, Mayall BH, Murphy RF, Sandberg AA (1984) Convention on nomenclature for DNA cytometry. Cytometry 5: 445–446

    Article  Google Scholar 

  10. Andreeff M, Redner A, Thongprasert S, Eagle B, Steinherz P, Miller D, Melamed MR (1985) Multiparameter flow cytometry for determination of ploidy, proliferation and differentiation in acute leukemia: treatment effects and prognostic value. In: Buechner Th (ed) Tumor aneuploidy. Springer Berlin Heidelberg New York Tokyo, pp 81–105

    Google Scholar 

  11. Andreeff M, Assing G, Cirrincione C (1986) Prognostic value of DNA/RNA flow cytometry in myeloblastic and lymphoblastic leukemia in adults: RNA content and S-phase predict remission duration and survival in multivariate analysis. In: Andreeff M (ed) Clinical cytometry. (ed) Ann NY Acad Sci 468: 387–406

    Google Scholar 

  12. Cox DR (1972) Regression models and life tables (with discussion). J R Stat Soc B 34: 187–220

    Google Scholar 

  13. BMDP Statistical Software (1983) University of California Press. Berkeley, CA

    Google Scholar 

  14. Kalbfleisch JD, Prentice RL (1980) The statistical analysis of failure time data. Wiley, New York, pp 39–69 29.

    Google Scholar 

  15. Cox DR (1975) Partial likelihood. Biometrika 62: 269–276

    Article  Google Scholar 

  16. Mantel N (1966) Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 30. 50: 163–170

    Google Scholar 

  17. Peto R, Peto J (1972) Asympotically efficient rank invariant test procedures. J R Stat Soc A 135: 185–206

    Article  Google Scholar 

  18. Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53: 457–481

    Article  Google Scholar 

  19. Afifi AA, Elashoff RM (1966) Missing observations in multivariate statistics. I. Review of the literature. J Am Stat Assoc 61:595–605 Afifi AA, Elashoff RM (1967) Missing observations in multivariate statistics. II. Point estimation in simple linear regression. J Am Stat Assoc 62: 10–29

    Google Scholar 

  20. Afifi AA, Elashoff RM (1969) Missing observations in multivariate statistics. III. Large sample analysis of simple linear regression. J Am Stat Assoc 64: 337–358

    Google Scholar 

  21. Afifi AA, Elashoff RM (1967) Missing observations in mulitvariate statistics. III. Large sample analysis of simple linear regression.J Am Stat Assoc 64: 337–358

    Google Scholar 

  22. Gaynor J, Chapman D, Little C, Andreeff M, Gee T, Clarkson B (to be published) A cause-specific hazard rate analysis of prognostic factors among adult patients with Acute Lymphoblastic Leukemia (ALL): The Memorial Hospital Experience

    Google Scholar 

  23. Darzynkiewicz Z, Traganos F, Staiano-Coico L (1986) Cell and nuclear growth during G1: kinetic and clinical implications. In: Andreeff M (ed) Clinical cytometry. Ann NY Acad Sci 468: 45–54

    Google Scholar 

  24. Redner A, Andreeff M, Bagin R, Miller DR, Groshen S (1984) RNA content predicts early response in pediatric ALL: multivariate analysis of prognostic factors. Blood [Suppl] 64: 149a

    Google Scholar 

  25. Espiritu E, Welte K, Andreeff M (1985) Induction of Leu-11 on lymphoid leukemic cells by OKT3, PMA and IL-2. Proc Intl Conf Analyt Cytol 11: 355

    Google Scholar 

  26. Welte K, Andreeff M, Platzer E, Holloway K, Rubin BY, Moore MAS, Mertelsmann R (1984) Interleukin 2 regulates the expression of Tac antigen on peripheral blood T lymphocytes. J Exp Med 160: 1390–1403

    Article  PubMed  CAS  Google Scholar 

  27. Hart JS, George SL, Frei E III, Bodey GP, Nickerson RC, Freireich EJ (1977) Prognostic significance of pretreatment proliferative activity in adult acute leukemia. Cancer 39: 1603

    Article  PubMed  CAS  Google Scholar 

  28. Scarffe JH, Hann IM, Evans DI, Jones PH, Palmer MK, Lilleyman JS, Crowther D (1980) Relationship between the pretreatment proliferative activity of marrow blast cells and prognosis of acute lymphoblastic leukaemia of childhood. Br J Cancer 41: 764–770

    Article  PubMed  CAS  Google Scholar 

  29. Dow LW, Chang LJA, Tsiatis AA, Melvin SL, Bowman WP (1982) Relationship of pretreatment lymphoblast proliferative activity and prognosis in 97 children with acute lymphoblastic leukemia. Blood 59: 1197–1202

    PubMed  CAS  Google Scholar 

  30. Murphy SB, Melvin SL, Mauer AM (1979) Correlation of tumor cell kinetic studies with surface marker results in childhood non-Hodgkins lymphoma. Cancer Res 39: 15341538

    Google Scholar 

  31. Baccarani M, Corbelli G, Amadori S, Drenthe-Schonk A, Willemze R, Meloni G, Cardozo PL, Haanen C, Mandelli F, Turu S (1982) Adolescent and adult acute lymphoblastic leukemia: prognostic features and outcome of therapy. A study of 293 patients. Blood 60: 677–684

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Hematology/Lymphoma Service, Department of Medicine, Memorial Joan-Kettering Cancer Center, New York, NY, 10021, USA

    M. Andreeff, C. Little, T. Gee & B. D. Clarkson

  2. Leukemia Cell Biology Laboratory, Department of Medicine, Memorial Joan-Kettering Cancer Center, New York, NY, 10021, USA

    M. Andreeff

  3. Division of Biostatistics, Department of Medicine, Memorial Joan-Kettering Cancer Center, New York, NY, 10021, USA

    J. Gaynor & D. Chapman

Authors
  1. M. Andreeff
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  2. J. Gaynor
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  3. D. Chapman
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  4. C. Little
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  5. T. Gee
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  6. B. D. Clarkson
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Editor information

Editors and Affiliations

  1. Departments of Internal Medicine and Pediatrics, University of Münster, Albert-Schweitzer-Strasse 33, D-4400, Münster, Federal Republic of Germany

    T. Büchner , G. Schellong , W. Hiddemann , D. Urbanitz  & J. Ritter , , ,  & 

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© 1987 Springer-Verlag Berlin Heidelberg

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Andreeff, M., Gaynor, J., Chapman, D., Little, C., Gee, T., Clarkson, B.D. (1987). Prognostic Factors in Acute Lymphoblastic Leukemia in Adults: The Memorial Hospital Experience. In: Büchner, T., Schellong, G., Hiddemann, W., Urbanitz, D., Ritter, J. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71213-5_18

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  • DOI: https://doi.org/10.1007/978-3-642-71213-5_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16556-9

  • Online ISBN: 978-3-642-71213-5

  • eBook Packages: Springer Book Archive

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