Prognostic Factors in Acute Lymphoblastic Leukemia in Adults: The Memorial Hospital Experience

  • M. Andreeff
  • J. Gaynor
  • D. Chapman
  • C. Little
  • T. Gee
  • B. D. Clarkson
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 30)


Acute lymphoblastic leukemia (ALL) has become a curable disease through the development of effective treatment strategies based on polychemotherapy with non-crossresistant drugs, effective prophylaxis of central nervous system leukemia, and prolonged maintenance chemotherapy [1–4]. Lymhoblastic leukemia in children, in particular, has been treated successfully, with the majority of children surviving 5 years [5]. It was recognized during the early studies that patients had very different responses to standard therapy, and a number of models were developed to identify patient groups with different prognoses. As a consequence, children with ALL were treated differently, based on their classification as “low,”-“standard,”- or “high”-risk patients. Risk group assignments were mainly based on age, white blood cell count (WBC), and involvement of lymph nodes, hepatomegaly or splenomegaly in some series [5].


Acute Lymphoblastic Leukemia White Blood Cell Count Remission Duration Bone Marrow Blast High White Blood Cell Count 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • M. Andreeff
    • 1
    • 2
  • J. Gaynor
    • 3
  • D. Chapman
    • 3
  • C. Little
    • 1
  • T. Gee
    • 1
  • B. D. Clarkson
    • 1
  1. 1.Hematology/Lymphoma Service, Department of MedicineMemorial Joan-Kettering Cancer CenterNew YorkUSA
  2. 2.Leukemia Cell Biology Laboratory, Department of MedicineMemorial Joan-Kettering Cancer CenterNew YorkUSA
  3. 3.Division of Biostatistics, Department of MedicineMemorial Joan-Kettering Cancer CenterNew YorkUSA

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