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Risk Groups in Adult Acute Lymphoblastic Leukemia

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Acute Leukemias

Abstract

When the German multicenter trial for the treatment of adult acute lymphoblastic leukemia (ALL) and acute undifferentiated leukemia (AUL) was started in 1978, one of the main objectives was to establish prognostic factors for the definition of groups with increased risk of relapse. At that time, on the basis of large cooperative studies of childhood ALL, children could already be classified as being of standard risk or high risk [1]. It was also of interest whether the prognostic factors might differ when a comparable treatment strategy was applied to adults.

Supported by the Bundesministerium für Forschung und Technologie, Grants No. 01 ZW 024 and No. 01 ZW 014.

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References

  1. Niemeyer CH, Hitchcock-Bryan S, Sallan SE (1985) Comparative analysis of treatment programs for childhood acute lymphoblastic leukemia. Semin Oncol 12: 122–130

    PubMed  CAS  Google Scholar 

  2. Hoelzer D, Thiel E, Löffler H, et al. (1984) Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults.acute lymphoblastic leukemia therapy study,Blood 64: 38–47

    CAS  Google Scholar 

  3. Hoelzer D, Thiel E, Löffler H, et al. (1986)Treatment of minimal residual disease in adult ALL: The German national study. In: Hagen¬beek A, Löwenberg B (eds) Minimal residual disease in acute leukemia 1986. Martinus Nijhoff, Dordrecht, pp 196–204

    Google Scholar 

  4. Thiel E, Rodt H, Huhn D, et al. (1980) Multimarker classification of acute lymphoblastic leukemia: evidence for further T subgroups and evaluation of their clinical significance.Blood 56: 759–772

    CAS  Google Scholar 

  5. Riehm H, Gadner H, Henze G, Langermann HV, Odenwald E (1980) The Berlin childhood acute lymphoblastic leukemia therapy study,1970–1976.Am J Pediatr Hematol Oncol 2: 299–306

    Google Scholar 

  6. Clarkson B,Ellis S,Little C,et al.(1985)Acute lymphoblastic leukemia in adults.Semin Oncol 12:160–179

    Google Scholar 

  7. Gee T, Gulati C, Clarkson BD (1986) L-20 protocol for adult patients with acute lympho blastic leukemia: a protocol utilizing prog nostic factots, intensive chemotherapy and au tologous “purged” marrow transplantation to eradicate minimal residual disease. In: Hagen beek A, Löwenberg B (eds) Minimal residual disease 1986. Martinus Nijhoff, Dordrecht, pp 180–195

    Chapter  Google Scholar 

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© 1987 Springer-Verlag Berlin Heidelberg

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Hoelzer, D. et al. (1987). Risk Groups in Adult Acute Lymphoblastic Leukemia. In: Büchner, T., Schellong, G., Hiddemann, W., Urbanitz, D., Ritter, J. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71213-5_17

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  • DOI: https://doi.org/10.1007/978-3-642-71213-5_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16556-9

  • Online ISBN: 978-3-642-71213-5

  • eBook Packages: Springer Book Archive

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