The Effects of Fiber Length on the In Vitro Cytotoxicity of Asbestos Samples in Three Different Assay Systems
The ability of mineral fibers to cause disease in man is well established and the work of Stanton et al. (1977), Stanton and Layard (1978) and Pott (1978) has indicated that the ability of a dust to induce intrapleural tumors depends on the number of fibers in the sample that are greater than 8 pm in length and less than 1.5 μm in diameter.
KeywordsA549 Cell Fiber Diameter Fiber Length Mineral Dust Fiber Aspect Ratio
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- Beck EG, Tilkes F (1980) In Vitro effects of defined mineral fibres. In: Brown RC, Gormley IP, Chamberlain M, Davies R (eds). The in vitro effects of mi-neral dusts. Academic Press, London, p339Google Scholar
- Chamberlain M, Brown RC (1978) The cytotoxic effects of asbestos and other mineral dust in tissue culture cell lines. Brit J exp Pathol 59: 183–189Google Scholar
- Chamberlain M, Brown RC, Davies R, Griffiths DM (1979) In vitro prediction of the pathogenicity of mineral dusts. Brit J exp Pathol 60: 320–327Google Scholar
- Davis JMG, Bolton RE, Cowie H, Donaldson K, Gormley IP, Jones AD, Wright A (1984) These proceedingsGoogle Scholar
- Gormley IP, Collings P, Davis JMG, Ottery J (1979) An investigation into the cytotoxicity of respirable dusts from British collieries. Brit J exp Pathol 60: 526–535Google Scholar
- Pott F (1978) Some aspects on the dosimetry of the carcinogenic potency of asbestos and other fibrous dusts. Staub-Reinhalt Luft 38: 468–490Google Scholar
- Robock K (1973) Standard quartz DQ12<5μm for experimental pneumoconiosis research projects in the Federal Republic of Germany. Ann occup Hyg 16:63–66Google Scholar
- Siegel S (1956) Non-parametric statistics for the behavioural sciences, McGraw-Hill, New York, p202Google Scholar
- Stanton MF, Layard M (1978) The carcinogenicity of fibrous minerals. In: Gravatt CC, La Fleur PD, Heinreich KFJ (eds). Workshop on Asbestos: Definition and Measurement Methods. National Bureau of Standards Special Publication No. 506. National Measurements Laboratory Washington DC, p143Google Scholar
- Wade JM, Lipkin LE, Stanton MF, Frank AL (1980) P388D1 in vitro cytotoxicity assay as applied to asbestos and other minerals: its possible relevance to carcinogenicity. In: Brown RC, Gormley IP, Chamberlain M, Davies R (eds). The In Vitro Effects of Mineral Dusts. Academic Press, London, p351Google Scholar
- Wright A, Gormley IP, Collings PL, Davis JMG (1980) The cytotoxicity of asbestos and other fibrous dusts. In: Brown RC, Gormley IP, Chamberlain M, Davies R (eds). The In Vitro Effects of Mineral Dusts. Academic Press, London, p25Google Scholar