Lipid Peroxidation and the Generation of Malondialdehyde in Crocidolite-treated Cell Cultures
In recent years there have been a number of reports suggesting that oxygen free radicals may be implicated in mineral dust lung injury. In particular, asbestos has been shown to stimulate the produciton of oxygen radicals from polymorphonuclear leukocytes (eg. Doll et al. 1982). Weitzman and Graceffa (1984) have shown that crocidolite can catalyze the production of superoxide from hydrogen peroxide and that this reaction probably involves the iron associated with this type of fibre.
KeywordsA549 Cell Prostaglandin Synthesis Fibre Size Free Radical Damage Cumene Hydroperoxide
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