Lipid Peroxidation and the Generation of Malondialdehyde in Crocidolite-treated Cell Cultures

  • C. J. Turver
  • A. Poole
  • R. C. Brown
Part of the NATO ASI Series book series (volume 3)

Abstract

In recent years there have been a number of reports suggesting that oxygen free radicals may be implicated in mineral dust lung injury. In particular, asbestos has been shown to stimulate the produciton of oxygen radicals from polymorphonuclear leukocytes (eg. Doll et al. 1982). Weitzman and Graceffa (1984) have shown that crocidolite can catalyze the production of superoxide from hydrogen peroxide and that this reaction probably involves the iron associated with this type of fibre.

Keywords

Peroxide Dust Superoxide Aldehyde Bicarbonate 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bird AP, Draper HH, Basrur PK (1982) Effect of malonaldehyde on cultured mammalian cells. Production of micronuclei and chromosomal aberrations. Mutat Res 101: 237–246PubMedCrossRefGoogle Scholar
  2. Brown RC, Chamberlain M, Griffiths DM, Timbrell V (1978) The effect of fibre size on the in vitro biological activity of three types of amphibole asbestos. Int J Cancer 22: 721–727PubMedCrossRefGoogle Scholar
  3. Brown RC, Poole A (1984) Arachidonic acid release and prostaglandin synthesis in a macrophage-like cell line exposed to asbestos. Agents and Actions in the pressGoogle Scholar
  4. Doll NJ, Stankus RP, Goldbach S, Salvaggio JE (1982) In vitro effects of asbestos fibers on polymorphonuclear leukocyte function. Int Arch Allergy appl Immunol 68: 17–21PubMedCrossRefGoogle Scholar
  5. Gabor S, Anca Z (1975) Effects of asbestos on lipid peroxidation in red cells B J Indust Med 32: 39–41Google Scholar
  6. Gavino VC, Ikarebha SO, Milo GE, Cornwell DG (1981) Effects of polyunsaturated fatty acids on lipid peroxidation in tissue cultures. J Lipid Res 22: 763–769PubMedGoogle Scholar
  7. Halliwell B (1981) The biological effects of the superoxide radical and its products. Bull Europ Physiopath Resp 17 suppl:21–28Google Scholar
  8. Sirois P, Rola-Pleszczynski M, Begin R (1980) Phospholipase A activity and prostaglandin synthesis from alveolar macrophages exposed to asbestos. Prostaglandins and Medicine 5: 31–37PubMedCrossRefGoogle Scholar
  9. Wagner JC, Griffiths DM, Hill RJ (1984) The effect of fibre size on the in vivo activity of UICC crocidolite. B J Cancer 49: 453–458CrossRefGoogle Scholar
  10. Weitzman SA, Graceffa P (1984) Asbestos catalyzes hydroxyl and superoxide radical generation from hydrogen peroxide. Arch Biochem Biophys 228: 373–376PubMedCrossRefGoogle Scholar
  11. Yonei S, Furei H (1981) Lethal and mutagenic effects of malondialdehyde, a decomposition product of peroxidised lipids, on E. coli with different DNA repair capacities. Mutat Res 88: 23–32Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • C. J. Turver
    • 1
  • A. Poole
    • 1
  • R. C. Brown
    • 1
  1. 1.MRC Pneumoconiosis UnitLlandough HospitalPenarth, South GlamorganUK

Personalised recommendations