Abstract
Isosorbide dinitrate (ISDN) is very rapidly and almost completely denitrated in the liver with the formation of nitrite ions, isosorbide-5-mononitrate (IS-5-MN), and isosorbide-2-mononitrate(IS-2-MN).
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References
Di Felice A, Fratoni A, Galante A, Violante A (1970) Studio su alcune attivita’enzimatiche sieriche in conigli trattati con sodio nitrito. Quad Sclavo Diagn Clin Lab 6: 340
Strein K, Dietmann K, Bartsch W (1981) Nitrit und Methämoglobinbildung bei Hunden nach oraler Gabe von Isosorbiddinitrat, Isosorbid-2-Mononitrat und Isosorbid-5-Mononitrat. Med Welt 32: 499
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© 1985 Springer-Verlag Berlin Heidelberg
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Strein, K., Sponer, G., Bartsch, W. (1985). Differences in the Metabolism of Isosorbide-5-Mononitrate and Isosorbide Dinitrate and Their Consequences for Toxicologic Findings. In: Cohn, J.N., Rittinghausen, R. (eds) Mononitrates. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70234-1_8
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DOI: https://doi.org/10.1007/978-3-642-70234-1_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-15107-4
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