• Jay N. Cohn
  • Reiner Rittinghausen
Conference proceedings

Part of the International Boehringer Mannheim Symposia book series (BOEHRINGER)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Preface

    1. Jay N. Cohn
      Pages 1-2
  3. Introductory Remarks on the Development of Isosorbide-5-Mononitrate

  4. Vasodilation with Nitrates

  5. Clinical Pharmacology

    1. Front Matter
      Pages 51-51
    2. H.-L. Fung, S. C. Sutton, A. Kamiya
      Pages 67-72
    3. F. Raue, E. Ritz, W. Akpan, R. Endele, G. Neugebauer
      Pages 78-85
  6. Tolerance to Nitrates

    1. Front Matter
      Pages 93-93
    2. H. Ohlmeier, H. M. Mertens, H. Mannebach, U. Gleichmann
      Pages 107-123

About these proceedings


The nitrates have remarkable clinical effects that have stood the test of time in the management of ischemic heart disease. What is unusual about this class of com­ pounds is that, after many years of clinical use, we are still exploring new avenues as to the vascular mechanisms of their effect, their applications in treating other clini­ cal conditions, and the development of products with more favorable pharmacoki­ netic properties. This volume represents the proceedings of a symposium held June 14-16, 1984, in Montreux. The papers were selected to explore the current state of knowledge re­ garding the mechanisms of action, pharmacokinetics, and clinical efficacy of ni­ trates. Particular attention has been given to newer studies utilizing the 5-mononi­ trate metabolite of isosorbide dinitrate, a drug whose pharmacokinetic properties may make it an important new agent in the treatment of angina and congestive heart failure. One of the benefits of an international meeting of experts sharing their views on an internationally used group of drugs is that differences in concepts and clinical practice become apparent and can be discussed. The Montreux forum made it clear that clinicians in North and South America and Europe have diverging views on how the nitrates should be used.


Nitrat anatomy angina pectoris coronary artery disease depression drug heart kinetics metabolism pharmacokinetics pharmacology research

Editors and affiliations

  • Jay N. Cohn
    • 1
  • Reiner Rittinghausen
    • 2
  1. 1.Cardiovascular DivisionUniversity of MinnesotaMinneapolisUSA
  2. 2.Product DevelopmentBoehringer Mannheim GmbHMannheim 31Federal Republic of Germany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1985
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-15107-4
  • Online ISBN 978-3-642-70234-1
  • Series Print ISSN 0173-0282
  • Buy this book on publisher's site
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