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Comparison of Changes on Exercise-Induced Ischemia After a Single Oral Dose of IS-5-MN and ISDN

  • Conference paper
Mononitrates

Part of the book series: International Boehringer Mannheim Symposia ((BOEHRINGER))

Abstract

The antianginal effectiveness of isosorbide dinitrate (ISDN) has been demonstrated in many studies [1, 4, 5, 9, 10, 13, 14, 15, 17, 18]. Since the bioavailability of ISDN after oral application is negligible, its long-acting effects on the angina pectoris syndrome (APS) are related to the main metabolites isosorbide-2-mononitrate (IS-2-MN) and isosorbide-5-mononitrate (IS-5-MN) which show a prolonged half-life period [1, 8, 11, 13]. In contrast to ISDN, orally taken IS-5-MN has a bioavailability of 100% without any first-pass effect [1, 8, 11]. Because of these different pharmacodynamic properties, it was of interest to investigate the so-far open question of the equieffective oral dosage of ISDN and IS-5-MN.

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Authors
  1. R. Schoeller
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  2. H. Huckauf
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  3. U. Rennhak
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  4. T. Riebesel
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  5. R. Brüggemann
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  6. R. Schröder
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  7. G. Biamino
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Editor information

Editors and Affiliations

  1. Cardiovascular Division, University of Minnesota, Box 508, Mayo Memorial Building, 420 Delaware Street S. E., Minneapolis, 55455, MN, USA

    Jay N. Cohn Prof., M. D.

  2. Product Development, Boehringer Mannheim GmbH, Postfach 31 01 20, D-6800, Mannheim 31, Federal Republic of Germany

    Reiner Rittinghausen M. D.

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© 1985 Springer-Verlag Berlin Heidelberg

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Schoeller, R. et al. (1985). Comparison of Changes on Exercise-Induced Ischemia After a Single Oral Dose of IS-5-MN and ISDN. In: Cohn, J.N., Rittinghausen, R. (eds) Mononitrates. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70234-1_25

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  • DOI: https://doi.org/10.1007/978-3-642-70234-1_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15107-4

  • Online ISBN: 978-3-642-70234-1

  • eBook Packages: Springer Book Archive

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