Abstract
Although there is little doubt concerning the ready development of nitrate tolerance in vitro as well as in man in the industrial setting, the importance of this phenomenon in clinical therapeutics for cardiovascular disease remains a subject of active debate. One of the reasons for this debate is that the participants sometimes disagree on the definition of tolerance and the criteria by which it should be demonstrated. This paper will present a definition and classification of tolerance, review original isolated work on blood vessels and intact dog studies concerning tolerance to the organic nitrates from our experimental laboratory, and, finally, address the subject of clinical tolerance in man with congestive cardiac failure.
The trouble with being tolerant is that people think you don’t understand the problem.
M. L. Meacham
Supported in part by the Ontario Heart Foundation, Toronto, Canada
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© 1985 Springer-Verlag Berlin Heidelberg
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Armstrong, P.W., Moffat, J.A. (1985). Nitrate Tolerance: Animal Experiments and Clinical Studies in Heart Failure. In: Cohn, J.N., Rittinghausen, R. (eds) Mononitrates. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70234-1_14
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DOI: https://doi.org/10.1007/978-3-642-70234-1_14
Publisher Name: Springer, Berlin, Heidelberg
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