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Hormone Inducible Specific Gene Expression in an Isolated Whole Mammary Organ in Serum-Free Culture

  • Mihir R. Banerjee
  • Prabir K. Majumder
  • Michael Antoniou
  • Jay Joshi
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

Selective gene expression is believed to play a critical role in cellular differentiation associated with developmental processes (1). Functional differentiation (lactogenesis) of the mammary epithelial cells is accompanied by hormone-inducible expression of several specific gene products including the major milk-proteins, the casein (2). In the murine mammary gland, a glucocorticoid (Cortisol or corticosterone) and prolactin are the principal steroid and polypeptide hormones required for lactogenesis including the synthesis of the caseins, a phosphoprotein complex (3,4). Progesterone is also involved in this process and is known to act as a suppressor of lactogenesis (5). This chapter includes a brief discussion of our recent findings on the mode of action of the different steroid and polypeptide hormones involved in the regulation of the expression of the casein genes in an isolated whole mammary organ in vitro. Earlier studies on milk-protein gene expression in the mammary gland in vivo and in vitro have been reviewed in recent years (6–10).

Keywords

Mammary Gland Polypeptide Hormone Nuclear Binding Whey Acid Protein Mammary Organ 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Davidson, E. H. (1976) in: Gene Activity in Early Development. Academic Press, NY.Google Scholar
  2. 2.
    Banerjee, M. R. (1976) Int. Rev. Cytol. 46, 1–97.CrossRefGoogle Scholar
  3. 3.
    Nandi, S. (1958) J. Nat. Cancer Inst. 20, 1039–063.Google Scholar
  4. 4.
    Topper, Y. J. (1970) Rec. Prog. Hormone Res, 26, 287–308.Google Scholar
  5. 5.
    Assairi, L., Delouis, C. Caye, P., Houdebine, L. M., Olliver-Bousquet, M. and Denamur, R. (1974) Biochem. J. 144, 245–252.PubMedGoogle Scholar
  6. 6.
    Banerjee, M. R., Terry, P. M., Sakai, S., Lin, F. K. and Ganguly, R. (1978) In Vitro 14, 128–139.PubMedCrossRefGoogle Scholar
  7. 7.
    Banerjee, M. R., Ganguly, N. Mehta, N. M., Iyer, A. P. and Ganguly, R. (1980) in: Cell Biology of Breast Cancer (C. McGrath, M. Brennan and M. Rich, eds) Academic Press, NY, pp 485–516.Google Scholar
  8. 8.
    Banerjee, M. R., Mehta, N. M., Ganguly, R., Majumder, P. K., Ganguly, N. and Joshi, J. (1982) in: Conference on Cell Proliferation (D. A. Sibrasku, G. H. Sato and A. B. Pardee, eds) Cold Spring Harbor Laboratory, NY, vol. 9, pp. 789–805.Google Scholar
  9. 9.
    Topper, Y. J., and Freeman, C. S. (1980) Physiol. Rev. 60, 1049–1106.PubMedGoogle Scholar
  10. 10.
    Rosen, J. M., Matusik, R. Richard, D. A., Gupta, P. and Rodgers, J. R. (1980) Recent Prog. Horm. Res. 36, 157–193.PubMedGoogle Scholar
  11. 11.
    Ichinose, R. R. and Nandi, S. (1966) J. Endocrinol. 35, 331–340.PubMedCrossRefGoogle Scholar
  12. 12.
    Wood, B. G., Washburn, L. L., Mukherjee, A. S. and Banerjee, M. R. (1975) J. Endocrinol. 65, 1–6.PubMedCrossRefGoogle Scholar
  13. 13.
    Lin, F. K., Banerjee, M. R. and Crump, L. R. (1976) Cancer Res. 36, 1607–1614.PubMedGoogle Scholar
  14. 14.
    Banerjee, M. R., Wood, B. G., Lin, F. K. and Crump, L. R. (1976) in: Tissue Culture Assoc. Manual (K. K. Sanford, ed) Tissue Culture Assoc., Rockville, MD, vol. 2, pp 457–462.Google Scholar
  15. 15.
    Tonelli, Q. J. and Sorof, S. (1980) Nature 285, 250–252.PubMedCrossRefGoogle Scholar
  16. 16.
    Elias, J. J. (1957) Science 126, 842–844.PubMedCrossRefGoogle Scholar
  17. 17.
    Rivera, E. (1971) in: Methods in Mammalian Embryology (J. C. Danial, ed) Freeman, San Francisco, pp 442–471.Google Scholar
  18. 18.
    Wittliff, J. L. (1975) Methods in Cancer Res. 11, 293–354.Google Scholar
  19. 19.
    Gala, R. R. and Westphal, U. (1965) Acta Endocrinologica 55, 47–61.Google Scholar
  20. 20.
    Ganguly, N., Ganguly, R., Mehta, N. M. and Banerjee, M. R. (1982) J. Nat. Cancer Inst. 69, 453–463.PubMedGoogle Scholar
  21. 21.
    Terry, P. M., Ball, E. M. and Banerjee, M. R. (1975) Methods of Immunology 9, 123–124.CrossRefGoogle Scholar
  22. 22.
    Rosen, J. M. and Barker, S. (1976) Biochemistry 15, 5272–5280.PubMedCrossRefGoogle Scholar
  23. 23.
    Benerjee, M. R., Terry, P. M., Sakai, S. and Lin, F. K. (1977) in: Hormone Research III (N. Norvell and T. Shellenberger, eds) Hemisphere Publishing Corp., Washington, DC, pp 281–306.Google Scholar
  24. 24.
    Terry, P. M., Banerjee, M. R. and Lui, R. M. (1977) Proc. Natl. Acad. Sci. U.S.A. 74, 2441–2445.PubMedCrossRefGoogle Scholar
  25. 25.
    Ganguly, R., Mehta, N. M., Ganguly, N. and Banerjee, M. R. (1979) Proc. Natl. Acad. Sci. U.S.A. 76, 6466–6470.PubMedCrossRefGoogle Scholar
  26. 26.
    Mehta, N. M., Ganguly, N., Ganguly, R. and Banerjee, M. R. (1980) J. Biol. Chem. 255, 4430–4434.PubMedGoogle Scholar
  27. 27.
    Ganguly, R., Majumder, P. K., Ganguly, N. and Banerjee, M. R. (1982) J. Biol. Chem. 257, 2182–2187.PubMedGoogle Scholar
  28. 28.
    Tucker, H. A. (1974) in: Lactation, a Comprehensive Treatise (B. L. Larson and V. R. Smith, eds) Academic Press, NY, vol. 1, pp 277–326.Google Scholar
  29. 29.
    Ganguly, N., Ganguly, R., Mehta, N. M., Crump, L. R. and Banerjee, M. R. (1981) In Vitro 17, 55–60.PubMedCrossRefGoogle Scholar
  30. 30.
    Ganguly, R., Ganguly, N., Mehta, N. M. and Banerjee, M. R. (1980) Proc. Natl. Acad. Sci. U.S.A. 77, 6003–6006.PubMedCrossRefGoogle Scholar
  31. 31.
    Strobl, J. and Lippman, M. (1979) Cancer Res. 39, 3319 - 3329.PubMedGoogle Scholar
  32. 32.
    Bolander, F. F. Jr., Nicholas, K. R. and Topper, Y. J. (1979) Biochem. Biophys. Res. Comm. 91, 247–252.PubMedCrossRefGoogle Scholar
  33. 33.
    Guyette, W. A., Matusik, R. J. and Rosen, J. M. (1979) Cell 17, 1013–1023.PubMedCrossRefGoogle Scholar
  34. 34.
    Hobbs, A., Richards, D. A., Kessler, D. J. and Rosen, J. M. (1982) J. Biol. Chem. 257, 3598–3605.PubMedGoogle Scholar
  35. 35.
    O’Malley, B. W. and Means, A. R. (1974) Science 183, 610–620.PubMedCrossRefGoogle Scholar
  36. 36.
    Litwack, C. (1979) Trends in Biochemical Sciences, October, 217–220.Google Scholar
  37. 37.
    Shyamala, G. and Dickson, C. (1976) Nature 262, 107–112.PubMedCrossRefGoogle Scholar
  38. 38.
    Coty, W. A. (1980) J. Biol. Chem. 255, 8035–8037.Google Scholar
  39. 39.
    Disorbo, D. M. and Litwack, C. (1981) Biochem. Biophys. Res. Comm. 99, 1203–1208.PubMedCrossRefGoogle Scholar
  40. 40.
    Yamamoto, R. and Albert, B. (1976) Ann. Rev. Biochem. 38, 722–746.Google Scholar
  41. 41.
    Teyssot, B. and Houdebine, L. M. (1981) Eur. J. Biochem. 114, 597–608.PubMedCrossRefGoogle Scholar
  42. 42.
    Tucker, H. A. (1979) in: Seminars in Perinatology (T. K. Oliver and T. H. Kirschbaum, eds) Crun and Stratton, NY, vol. 3, pp 199–223.Google Scholar
  43. 43.
    Haslam, S. Z. and Shyamala, G. (1979) Endocrinology 105, 786–795.PubMedCrossRefGoogle Scholar
  44. 44.
    Rosen, J. M., O’Neal, D. L., McHugh, J. E. and Comstock, J. P. (1978) Biochemistry 17, 290–297.PubMedCrossRefGoogle Scholar
  45. 45.
    Ray, D. B., Horst, I. A., Jensen, R. W., Mills, N. C. and Kowal, J. (1981) Endocrinology 108, 584–590.PubMedCrossRefGoogle Scholar
  46. 46.
    Nicholas, K. R., Sankaran, L. and Topper, Y. J. (1981) Endocrinology 109, 978–980.PubMedCrossRefGoogle Scholar
  47. 47.
    Bolander, F. F., Jr., Nicholas, K. R., Judson, J. V. W. and Topper, Y. J. (1981) Proc. Natl. Acad. Sci. U.S.A. 78, 5682–5684.PubMedCrossRefGoogle Scholar
  48. 48.
    Nagamatsu, Y. and Oka, T. (1980) Biochem. J. 185, 227–237.PubMedGoogle Scholar
  49. 49.
    Zamierowski, M. M. and Ebner, K. E. (1980) J. Immun. Methods 36, 211–220.CrossRefGoogle Scholar
  50. 50.
    Piletz, J. E. Heinlen, M., Canschow, R. E. (1981) J. Biol. Chem. 256, 11509–11516.PubMedGoogle Scholar
  51. 51.
    Hennighausen, L. G. and Sippel, A. (1982) Eur. J. Biochem. 125, 125–131.CrossRefGoogle Scholar
  52. 52.
    Dandekar, A. M. and Quasba, P. K. (1981) Proc. Natl. Acad. Sci. U.S.A. 78, 4853–4957.PubMedCrossRefGoogle Scholar
  53. 53.
    Mehta, N. M., El-Gewely, M. R., Joshi, J., Helling, R. B. and Banerjee, M. R. (1981) Gene 15, 285–288.PubMedCrossRefGoogle Scholar
  54. 54.
    Hall, L., Craig, R. K., Davis, M. S., Ralfs, D. N. L. and Campbell, P. N. (1981) Nature (Lond.) 290, 602–604.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • Mihir R. Banerjee
    • 1
  • Prabir K. Majumder
    • 1
  • Michael Antoniou
    • 1
  • Jay Joshi
    • 1
  1. 1.Tumor Biology Laboratory, School of Life SciencesUniversity of NebraskaLincolnUSA

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