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Hormone Inducible Specific Gene Expression in an Isolated Whole Mammary Organ in Serum-Free Culture

  • Conference paper
Hormonally Defined Media

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

  • 78 Accesses

Abstract

Selective gene expression is believed to play a critical role in cellular differentiation associated with developmental processes (1). Functional differentiation (lactogenesis) of the mammary epithelial cells is accompanied by hormone-inducible expression of several specific gene products including the major milk-proteins, the casein (2). In the murine mammary gland, a glucocorticoid (Cortisol or corticosterone) and prolactin are the principal steroid and polypeptide hormones required for lactogenesis including the synthesis of the caseins, a phosphoprotein complex (3,4). Progesterone is also involved in this process and is known to act as a suppressor of lactogenesis (5). This chapter includes a brief discussion of our recent findings on the mode of action of the different steroid and polypeptide hormones involved in the regulation of the expression of the casein genes in an isolated whole mammary organ in vitro. Earlier studies on milk-protein gene expression in the mammary gland in vivo and in vitro have been reviewed in recent years (6–10).

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References

  1. Davidson, E. H. (1976) in: Gene Activity in Early Development. Academic Press, NY.

    Google Scholar 

  2. Banerjee, M. R. (1976) Int. Rev. Cytol. 46, 1–97.

    Article  Google Scholar 

  3. Nandi, S. (1958) J. Nat. Cancer Inst. 20, 1039–063.

    Google Scholar 

  4. Topper, Y. J. (1970) Rec. Prog. Hormone Res, 26, 287–308.

    CAS  Google Scholar 

  5. Assairi, L., Delouis, C. Caye, P., Houdebine, L. M., Olliver-Bousquet, M. and Denamur, R. (1974) Biochem. J. 144, 245–252.

    PubMed  CAS  Google Scholar 

  6. Banerjee, M. R., Terry, P. M., Sakai, S., Lin, F. K. and Ganguly, R. (1978) In Vitro 14, 128–139.

    Article  PubMed  CAS  Google Scholar 

  7. Banerjee, M. R., Ganguly, N. Mehta, N. M., Iyer, A. P. and Ganguly, R. (1980) in: Cell Biology of Breast Cancer (C. McGrath, M. Brennan and M. Rich, eds) Academic Press, NY, pp 485–516.

    Google Scholar 

  8. Banerjee, M. R., Mehta, N. M., Ganguly, R., Majumder, P. K., Ganguly, N. and Joshi, J. (1982) in: Conference on Cell Proliferation (D. A. Sibrasku, G. H. Sato and A. B. Pardee, eds) Cold Spring Harbor Laboratory, NY, vol. 9, pp. 789–805.

    Google Scholar 

  9. Topper, Y. J., and Freeman, C. S. (1980) Physiol. Rev. 60, 1049–1106.

    PubMed  CAS  Google Scholar 

  10. Rosen, J. M., Matusik, R. Richard, D. A., Gupta, P. and Rodgers, J. R. (1980) Recent Prog. Horm. Res. 36, 157–193.

    PubMed  CAS  Google Scholar 

  11. Ichinose, R. R. and Nandi, S. (1966) J. Endocrinol. 35, 331–340.

    Article  PubMed  CAS  Google Scholar 

  12. Wood, B. G., Washburn, L. L., Mukherjee, A. S. and Banerjee, M. R. (1975) J. Endocrinol. 65, 1–6.

    Article  PubMed  CAS  Google Scholar 

  13. Lin, F. K., Banerjee, M. R. and Crump, L. R. (1976) Cancer Res. 36, 1607–1614.

    PubMed  CAS  Google Scholar 

  14. Banerjee, M. R., Wood, B. G., Lin, F. K. and Crump, L. R. (1976) in: Tissue Culture Assoc. Manual (K. K. Sanford, ed) Tissue Culture Assoc., Rockville, MD, vol. 2, pp 457–462.

    Google Scholar 

  15. Tonelli, Q. J. and Sorof, S. (1980) Nature 285, 250–252.

    Article  PubMed  CAS  Google Scholar 

  16. Elias, J. J. (1957) Science 126, 842–844.

    Article  PubMed  CAS  Google Scholar 

  17. Rivera, E. (1971) in: Methods in Mammalian Embryology (J. C. Danial, ed) Freeman, San Francisco, pp 442–471.

    Google Scholar 

  18. Wittliff, J. L. (1975) Methods in Cancer Res. 11, 293–354.

    CAS  Google Scholar 

  19. Gala, R. R. and Westphal, U. (1965) Acta Endocrinologica 55, 47–61.

    Google Scholar 

  20. Ganguly, N., Ganguly, R., Mehta, N. M. and Banerjee, M. R. (1982) J. Nat. Cancer Inst. 69, 453–463.

    PubMed  CAS  Google Scholar 

  21. Terry, P. M., Ball, E. M. and Banerjee, M. R. (1975) Methods of Immunology 9, 123–124.

    Article  CAS  Google Scholar 

  22. Rosen, J. M. and Barker, S. (1976) Biochemistry 15, 5272–5280.

    Article  PubMed  CAS  Google Scholar 

  23. Benerjee, M. R., Terry, P. M., Sakai, S. and Lin, F. K. (1977) in: Hormone Research III (N. Norvell and T. Shellenberger, eds) Hemisphere Publishing Corp., Washington, DC, pp 281–306.

    Google Scholar 

  24. Terry, P. M., Banerjee, M. R. and Lui, R. M. (1977) Proc. Natl. Acad. Sci. U.S.A. 74, 2441–2445.

    Article  PubMed  CAS  Google Scholar 

  25. Ganguly, R., Mehta, N. M., Ganguly, N. and Banerjee, M. R. (1979) Proc. Natl. Acad. Sci. U.S.A. 76, 6466–6470.

    Article  PubMed  CAS  Google Scholar 

  26. Mehta, N. M., Ganguly, N., Ganguly, R. and Banerjee, M. R. (1980) J. Biol. Chem. 255, 4430–4434.

    PubMed  CAS  Google Scholar 

  27. Ganguly, R., Majumder, P. K., Ganguly, N. and Banerjee, M. R. (1982) J. Biol. Chem. 257, 2182–2187.

    PubMed  CAS  Google Scholar 

  28. Tucker, H. A. (1974) in: Lactation, a Comprehensive Treatise (B. L. Larson and V. R. Smith, eds) Academic Press, NY, vol. 1, pp 277–326.

    Google Scholar 

  29. Ganguly, N., Ganguly, R., Mehta, N. M., Crump, L. R. and Banerjee, M. R. (1981) In Vitro 17, 55–60.

    Article  PubMed  CAS  Google Scholar 

  30. Ganguly, R., Ganguly, N., Mehta, N. M. and Banerjee, M. R. (1980) Proc. Natl. Acad. Sci. U.S.A. 77, 6003–6006.

    Article  PubMed  CAS  Google Scholar 

  31. Strobl, J. and Lippman, M. (1979) Cancer Res. 39, 3319 - 3329.

    PubMed  CAS  Google Scholar 

  32. Bolander, F. F. Jr., Nicholas, K. R. and Topper, Y. J. (1979) Biochem. Biophys. Res. Comm. 91, 247–252.

    Article  PubMed  CAS  Google Scholar 

  33. Guyette, W. A., Matusik, R. J. and Rosen, J. M. (1979) Cell 17, 1013–1023.

    Article  PubMed  CAS  Google Scholar 

  34. Hobbs, A., Richards, D. A., Kessler, D. J. and Rosen, J. M. (1982) J. Biol. Chem. 257, 3598–3605.

    PubMed  CAS  Google Scholar 

  35. O’Malley, B. W. and Means, A. R. (1974) Science 183, 610–620.

    Article  PubMed  Google Scholar 

  36. Litwack, C. (1979) Trends in Biochemical Sciences, October, 217–220.

    Google Scholar 

  37. Shyamala, G. and Dickson, C. (1976) Nature 262, 107–112.

    Article  PubMed  CAS  Google Scholar 

  38. Coty, W. A. (1980) J. Biol. Chem. 255, 8035–8037.

    Google Scholar 

  39. Disorbo, D. M. and Litwack, C. (1981) Biochem. Biophys. Res. Comm. 99, 1203–1208.

    Article  PubMed  CAS  Google Scholar 

  40. Yamamoto, R. and Albert, B. (1976) Ann. Rev. Biochem. 38, 722–746.

    Google Scholar 

  41. Teyssot, B. and Houdebine, L. M. (1981) Eur. J. Biochem. 114, 597–608.

    Article  PubMed  CAS  Google Scholar 

  42. Tucker, H. A. (1979) in: Seminars in Perinatology (T. K. Oliver and T. H. Kirschbaum, eds) Crun and Stratton, NY, vol. 3, pp 199–223.

    Google Scholar 

  43. Haslam, S. Z. and Shyamala, G. (1979) Endocrinology 105, 786–795.

    Article  PubMed  CAS  Google Scholar 

  44. Rosen, J. M., O’Neal, D. L., McHugh, J. E. and Comstock, J. P. (1978) Biochemistry 17, 290–297.

    Article  PubMed  CAS  Google Scholar 

  45. Ray, D. B., Horst, I. A., Jensen, R. W., Mills, N. C. and Kowal, J. (1981) Endocrinology 108, 584–590.

    Article  PubMed  CAS  Google Scholar 

  46. Nicholas, K. R., Sankaran, L. and Topper, Y. J. (1981) Endocrinology 109, 978–980.

    Article  PubMed  CAS  Google Scholar 

  47. Bolander, F. F., Jr., Nicholas, K. R., Judson, J. V. W. and Topper, Y. J. (1981) Proc. Natl. Acad. Sci. U.S.A. 78, 5682–5684.

    Article  PubMed  CAS  Google Scholar 

  48. Nagamatsu, Y. and Oka, T. (1980) Biochem. J. 185, 227–237.

    PubMed  CAS  Google Scholar 

  49. Zamierowski, M. M. and Ebner, K. E. (1980) J. Immun. Methods 36, 211–220.

    Article  CAS  Google Scholar 

  50. Piletz, J. E. Heinlen, M., Canschow, R. E. (1981) J. Biol. Chem. 256, 11509–11516.

    PubMed  Google Scholar 

  51. Hennighausen, L. G. and Sippel, A. (1982) Eur. J. Biochem. 125, 125–131.

    Article  Google Scholar 

  52. Dandekar, A. M. and Quasba, P. K. (1981) Proc. Natl. Acad. Sci. U.S.A. 78, 4853–4957.

    Article  PubMed  CAS  Google Scholar 

  53. Mehta, N. M., El-Gewely, M. R., Joshi, J., Helling, R. B. and Banerjee, M. R. (1981) Gene 15, 285–288.

    Article  PubMed  CAS  Google Scholar 

  54. Hall, L., Craig, R. K., Davis, M. S., Ralfs, D. N. L. and Campbell, P. N. (1981) Nature (Lond.) 290, 602–604.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Tumor Biology Laboratory, School of Life Sciences, University of Nebraska, Lincoln, NB, 68588-0342, USA

    Mihir R. Banerjee, Prabir K. Majumder, Michael Antoniou & Jay Joshi

Authors
  1. Mihir R. Banerjee
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  2. Prabir K. Majumder
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  3. Michael Antoniou
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  4. Jay Joshi
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Editor information

Editors and Affiliations

  1. Institut für Neurobiologie, Universität Heidelberg, Im Neuenheimer Feld 504, 6900, Heidelberg 1, Germany

    G. Fischer

  2. Institut für Pharmakologie, Universität Mainz, Obere Zahlbacher Str. 67, 6500, Mainz, Germany

    R. J. Wieser

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© 1983 Springer-Verlag Berlin Heidelberg

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Banerjee, M.R., Majumder, P.K., Antoniou, M., Joshi, J. (1983). Hormone Inducible Specific Gene Expression in an Isolated Whole Mammary Organ in Serum-Free Culture. In: Fischer, G., Wieser, R.J. (eds) Hormonally Defined Media. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69290-1_29

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  • DOI: https://doi.org/10.1007/978-3-642-69290-1_29

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69292-5

  • Online ISBN: 978-3-642-69290-1

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