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Use of Drug Combinations

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Antimalarial Drug II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 68 / 2))

Abstract

A general account of the different types of drug combination was given in this part, Chap. 6, and other references have appeared in other chapters, notably Part I, Chap. 14 and this part, Chaps. 4, 5, 7 and 13.

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References

  • Bishop A, Birkett B (1947) Acquired resistance to paludrine in Plasmodium gallinaceum. Acquired resistance and persistence after passage through the mosquito. Nature 159:884–885

    Article  PubMed  CAS  Google Scholar 

  • Bruce-Chwatt LJ (ed), Black RH, Canfield CJ, Clyde DF, Peters W, Wernsdorfer W (1981) Chemotherapy of malaria, 2nd edn. WHO, Geneva

    Google Scholar 

  • Chin W, Contacos PG, Coatney GR, King HK (1966) The evaluation of sulfonamides, alone or in combination with pyrimethamine, in the treament of multi-resistant falciparum malaria. Am J Trop Med Hyg 15:823–829

    PubMed  CAS  Google Scholar 

  • Merkli B, Richle RW (1980) Studies on the resistance to single and combined antimalarials in the Plasmodium berghei mouse model. Acta Trop (Basel) 37:228–231

    CAS  Google Scholar 

  • Merkli B, Richle R, Peters W (1980) The inhibitory effect of a drug combination on the development of mefloquine resistance in Plasmodium berghei. Ann Trop Med Parasitol 74:1–9

    PubMed  CAS  Google Scholar 

  • Mitsuhashi S (ed) (1977) R factor drug-resistant plasmid. University of Tokyo Press, Tokyo

    Google Scholar 

  • Peters W (1965a) Mepacrine-and primaquine-resistant strains of Plasmodium berghei, Vincke and Lips, 1948. Nature 208:693–694

    Article  CAS  Google Scholar 

  • Peters W (1965b) Drug resistance in Plasmodium berghei, Vincke and Lips, 1948. III. Multiple drug resistance. Exp Parasitol 17:97–102

    Article  PubMed  CAS  Google Scholar 

  • Peters W (1966) Drug responses of mepacrine-and primaquine-resistant strains of Plasmodium berghei, Vincke and Lips, 1948. Ann Trop Med Parasitol 60:25–30

    PubMed  CAS  Google Scholar 

  • Peters W (1969) Partial inhibition by mepacrine of the development of sulphonamide resistance in Plasmodium berghei. Nature 223:858–859

    Article  PubMed  CAS  Google Scholar 

  • Peters W (1970) Chemotherapy and drug resistance in malaria. Academic, London

    Google Scholar 

  • Peters W (1974) Prevention of drug resistance in rodent malaria by the use of drug mixtures. Bull WHO 51:379–383

    PubMed  CAS  Google Scholar 

  • Peters W, Gregory KG (1973) The chemotherapy of rodent malaria. XVI:primary resistance to mepacrine in the N67 strain of Plasmodium berghei-type parasite. Ann Trop Med Parasitol 67:133–141

    PubMed  CAS  Google Scholar 

  • Peters W, Portus JH, Robinson BL (1973) The chemotherapy of rodent malaria. XVII:dynamics of drug resistance, part 3. Influence of drug combinations on the development of resistance to chloroquine in P. berghei. Ann Trop Med Parasitol 67:143–154

    PubMed  CAS  Google Scholar 

  • Peters W, Howells RE, Portus JH, Robinson BL, Thomas S, Warhurst DC (1977a) The chemotherapy of rodent malaria. XXVII:studies on mefloquine (WR 142, 490). Ann Trop Med Parasitol 71:407–418

    PubMed  CAS  Google Scholar 

  • Peters W, Portus J, Robinson BL (1977b) The chemotherapy of rodent malaria. XXVIII:the development of resistance to mefloquine (WR 142, 490). Ann Trop Med Parasitol 71:419–427

    PubMed  CAS  Google Scholar 

  • Peters W, Chance ML, Lissner R, Momen H, Warhurst DC (1978) The chemotherapy of rodent malaria. XXX:the enigmas of the “NS lines” of P. berghei. Ann Trop Med Parasitol 72:23–36

    PubMed  CAS  Google Scholar 

  • Powers KG, Jacobs RL, Good WC, Koontz LC (1969) Plasmodium vinckei:production of chloroquine-resistant strain. Exp Parasitol 26:193–202

    Article  PubMed  CAS  Google Scholar 

  • Rabinovich SA (1965) Experimental investigations of antimalarial drug Haloquine. III Investigation of the possibility to restrain the development of chemoresistance to chloridine (Daraprim) by combined administration of chloridine with Haloquine. Medskaya Parazit 34:434–439

    CAS  Google Scholar 

  • Ramakrishnan SP, Satya Prakash Choudhury DA (1957) Selection of a strain of Plasmodium berghei highly resistant to chloroquine (“Resochin”). Nature 179:975

    Article  PubMed  CAS  Google Scholar 

  • Rieckmann KH (1967) A new repository antimalarial agent, CI-564 used in a field trial in New Guinea. Trans R Soc Trop Med Hyg 61:189–198

    Article  PubMed  CAS  Google Scholar 

  • Rollo IM (1951) A 2:4-diamino pyrimidine in the treatment of proguanil-resistant laboratory malarial strains. Nature 168:332–333

    Article  PubMed  CAS  Google Scholar 

  • Rollo IM (1952) “Daraprim” resistance in experimental malarial infections. Nature 170:415

    Article  PubMed  CAS  Google Scholar 

  • Rosario VE (1976) Genetics of chloroquine resistance in malaria parasites. Nature 261:585–586

    Article  PubMed  CAS  Google Scholar 

  • Rozman RS, Canfield CJ (1979) New experimental antimalarial drugs. Adv Pharmacol Chemother 16:1–43

    Article  PubMed  CAS  Google Scholar 

  • Sautet J,Aldighieri J, Aldighieri R, Arnaud G, Ausseil M; Rampal C, Castelli C (1959) Etudes sur la production expérimentale de la résistance a divers produits antimalariques d’une souche de Plasmodium berghei. Bull Soc Path Exot Filiales 52:331–345

    CAS  Google Scholar 

  • Schmidt LH, Harrison J, Rossan RN, Vaughan D, Crosby R (1977) Quantitative aspects of pyrimethamine-sulfonamide synergism. Am J Trop Med Hyg 26:837–849

    PubMed  CAS  Google Scholar 

  • Sevag MG (1964) Prevention of the emergence of antibiotic-resistant strains of bacteria by atabrine. Arch Biochem Biophys 108:85–88

    Article  PubMed  CAS  Google Scholar 

  • Thompson PE, Bayles A, Olszewski B, Waitz JA (1965) Studies on a dihydrotriazine and a sulfone, alone and in combination, against Plasmodium berghei in mice. Am J Trop Med Hyg 14:198–206

    PubMed  CAS  Google Scholar 

  • Tigertt WD, Clyde DF (1976) Drug resistance in the human malarias. Antibiot Chemother 20:246–272

    Google Scholar 

  • Warhurst DC, Killick-Kendrick R (1967) Spontaneous resistance to chloroquine in a strain of rodent malaria (Plasmodium berghei yoelii). Nature 213:1048–1049

    Article  CAS  Google Scholar 

  • Warren GH, Gregory FJ, Healey EMH, Flint SF (1967) Effect of mixtures of atabrine and antibacterial agents on the emergence of resistant strains of Mycobacterium tuberculosis. Nature 215:526–527

    Article  PubMed  CAS  Google Scholar 

  • Who (1966) WHO Expert Committee on Malaria. 12th Report. WHO Tech Rep Ser :324 (1966)

    Google Scholar 

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© 1984 Springer-Verlag Berlin Heidelberg

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Peters, W. (1984). Use of Drug Combinations. In: Peters, W., Richards, W.H.G. (eds) Antimalarial Drug II. Handbook of Experimental Pharmacology, vol 68 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69254-3_16

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  • DOI: https://doi.org/10.1007/978-3-642-69254-3_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69256-7

  • Online ISBN: 978-3-642-69254-3

  • eBook Packages: Springer Book Archive

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